The present application relates to a light and dark dual-mode regulation wound microenvironment material and its preparation method and application, and belongs to the technical field of biomedical functional materials. The
chemical formula of the material is MoO 3‑x / Ho2O3 / N-C, MoO 3‑x / Ho2O3 nanoparticles are loaded, coated or embedded in a
nitrogen-
doped carbon skeleton, wherein 0<=x<=2. The present application also provides a preparation method of the material and its application in preparing treatment of infected diabetic wounds, chronic non-
healing wounds, bacterial infection wounds,
oxidative stress related
tissue damage and vascular repair products. The light and dark dual-mode regulation wound microenvironment material provided by the present application has SOD-like and CAT-like nanoscale
enzyme activity, can inhibit
bacteria and kill
bacteria, reduce
oxidative damage, and protect fibroblasts, endothelial cells and macrophages. At the same time, it covers multiple
pathological links such as bacterial infection,
lactic acid accumulation, ROS excess,
inflammation persistence and insufficient vascularization in infected diabetic wounds, and has more complete wound microenvironment regulation ability.