A pharmaceutical composition for treating liver cirrhosis is provided; the pharmaceutical composition is composed of the pharmaceutical raw materials: vervain, adenophora stricta miq., liquorice, radix sanguisorbae, sanguis draxonis, polygonum cuspidatum, fructus ligustri lucidi, rhizoma corydalis, wild buckwheat, rhizoma imperatae, spica prunellae, akebia stem, radix gentianae macrophyllae, erythrina variegata, endothelium corneum gigeriae galli, dandelion, capillary artemisia, rhizoma ligustici wallichii, roughhaired holly, safflower, herba lysimachiae, rhizoma sparganii, buddleja asiatica, piper hancei, kadsura pepper stem, barbed skullcap herb, pseudo-ginseng, spreading hedyotis herb, rhizoma gastrodiae, phyllanthus urinaria, agastache rugosus, gynostemma pentaphylla, fructus liquidambaris and cassia twig. The drug components in the combination are cooperative with each other, together play effects of clearing away heat and detoxifying, soothing liver and regulating circulation of qi, and promoting blood circulation to remove blood stasis, and have obvious effects in use for improving the living quality of patients with liver cirrhosis.