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This invention belongs to the field of biochemistry, specifically relating to a macrophage-inspired biomimetic nanocomposite drug, its preparation method, and its application. The preparation method of this macrophage-inspired biomimetic nanocomposite drug includes the following steps: A) reducing chloroplatinic acid to platinum nanoparticles using a trisodium citrate reduction method; B) polymerizing the platinum nanoparticles obtained in step A using a cross-linking agent to obtain platinum nanozyme clusters; C) mixing the platinum nanozyme clusters obtained in step B with a macrophage membrane and sonicating to obtain the macrophage-inspired platinum nanozyme cluster composite drug. This drug can effectively promote kidney repair and can be used to alleviate inflammatory and oxidative stress responses after acute kidney injury, promoting the recovery of normal kidney function.