New technique for preparing drop pills and special dripper device

A technology of dripping pills and drippers, which is applied in the direction of making medicines into special physical or taking forms of devices, to achieve the effect of changing the dependence of drug properties and improving accuracy and safety

Inactive Publication Date: 2008-12-24
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the aforementioned technical difficulties, many traditional Chinese medicine prescriptions (especially multi-flavored Chinese medicine compound) are difficult to be prepared into practical drop pill preparations with many advantages in practice.

Method used

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  • New technique for preparing drop pills and special dripper device
  • New technique for preparing drop pills and special dripper device
  • New technique for preparing drop pills and special dripper device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1: Dripper device without feed one-way valve

[0060] figure 2 It is a realization of the dripper device in the special equipment for quantitative dripping. The device is not equipped with a one-way valve at the inlet of the liquid medicine, but only has a one-way valve at the outlet. In the figure, 1 is the quantitative plunger rod, 2 is the dripper, 3 is the one-way valve of the discharge port, 4 is the spring, 5 is the drug inlet, 6 is the plunger cavity, 7 is the screw plug, 8 is the sealing ring, 9 It is the main body of the dripper device. When the plunger rod retreats in the direction of the arrow, the volume of the chamber where the plunger rod is located expands, the pressure decreases, and the liquid medicine enters and fills the volume space vacated by the retreat of the plunger rod. When the plunger rod advances, the pressure in the cavity increases, and the one-way valve is opened by this pressure, and the liquid medicine drips out from the dripp...

Embodiment 2

[0061] Example 2. Dripper device with feed one-way valve

[0062] image 3 Another implementation of the dripper device in the special equipment for quantitative dripping, the device is also equipped with a one-way valve at the feeding port. In the figure, 1 is a quantitative plunger rod, 2 is a dripper, 3 is a one-way valve (including one at the inlet and outlet), 4 is a spring, 5 is a drug inlet, 6 is a plunger chamber, 7 8 is a sealing ring, 9 is the main body of the dripper device, and the one-way valve is a passive mode of spring compression. When the plunger rod retreats in the direction of the arrow, the volume of the chamber where the plunger rod is located expands, the pressure decreases, the one-way valve at the inlet is opened, the one-way valve at the outlet is closed, and the liquid medicine enters through the one-way valve at the inlet. And be full of the volume space that the plunger rod retreats to give up. When the plunger rod is pushed forward, the pressur...

Embodiment 3

[0064] Embodiment 3. The dripper device that adopts camshaft control

[0065] Figure 4 It is the third way of quantitative dripping, wherein: 1 is a quantitative plunger rod, 2 is a camshaft, 3 is a one-way valve, 4 is a cam, 5 is a drug inlet, and 6 is a drug outlet. When the camshaft rotates in the direction shown in the figure, it drives the three cams to rotate simultaneously. When the camshaft rotates to the position shown in the left figure, the left cam moves to the near rest end, the state of the drug inlet is open, the right cam moves to the far rest end, and the state of the drug outlet is closed. The process at the rest end drives the quantitative plunger rod to move upward, the volume of the chamber where the plunger rod is located expands, the pressure decreases, and the liquid medicine enters from the drug inlet and fills the volume space vacated by the rise of the plunger rod. After the plunger rod rises to the top, the middle cam moves to the near rest end, ...

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Abstract

The invention relates to a preparation method for oral preparation of a pharmaceutical composition and its special parts, in particular to a new technique for preparing dropping pills and its special parts. The purpose of the present invention is to make up for the deficiencies in the existing drop pill preparation technology, provide a kind of different characteristics that can be suitable for many drug varieties, and can easily prepare the preparation method of large-scale drop pills above 100 mg and its special dripper device.

Description

technical field [0001] The invention relates to a preparation method for oral preparation of a pharmaceutical composition and special parts thereof, in particular to a new technique for preparing dropping pills and special parts thereof. Background technique [0002] Dropping pills use solid dispersion technology to heat and melt the active ingredient of the drug and the pharmaceutically acceptable carrier as the matrix (it can be a melt, emulsion or suspension) and drop it into an immiscible condensate. In the drug, the oral preparation of a pharmaceutical composition is formed by rapidly shrinking the liquid drug droplet under the high-temperature state under the tension generated on the surface when it is suddenly cooled to form a pellet, and then condensed and solidified. Compared with conventional oral preparations, there are essential differences in the drop pills prepared by utilizing the above principles. [0003] Most of the traditional oral preparations are prepar...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61J3/06
Inventor曲韵智赵志明刘瑞兰
Owner北京博智绿洲医药科技有限公司