Sesquiterpene ketone injection, preparing method and use thereof

A technology for injections and hemiterpene ketones, which can be applied in the directions of ketone active ingredients, pharmaceutical formulations, and medical preparations containing active ingredients, etc. Problems such as giving data on the average particle size of liposomes

Inactive Publication Date: 2009-03-25
谢恬
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  • Description
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Problems solved by technology

[0011] Chinese patent publication CN1110134A relates to liposome preparation process and preparation, wherein particularly describes the preparation method of elemene liposome injection and the elemene liposome injection obtained by the method, the encapsulation efficiency of elemene is up to More than 85%, but no data are given on the average particle size of liposomes
[0012] Chinese patent publication CN1221607A relates to the use of CO 2 The critical or supercritical method prepares the technology of fat-soluble drug liposome and prepared elemene liposome injection, although the encapsulation efficiency of the liposome of elemene is very high, but the average of liposome The particle size is also too large
[0013] The preparations disclosed in the above documents all have deficiencies in storage stability and anticancer activity.

Method used

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  • Sesquiterpene ketone injection, preparing method and use thereof
  • Sesquiterpene ketone injection, preparing method and use thereof

Examples

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preparation example 1

[0069] Preparation Example 1: Preparation of Sesquiterpene Ketone-Containing Extract by Molecular Distillation of Chuan Curcuma Volatile Oil

[0070] With 1000ml of Sichuan turmeric volatile oil (containing about 15wt% gemaconone) as raw material, it is refined by Guangzhou Hanwei Electromechanical Co., Ltd. MD-S80 molecular distillation apparatus. The process conditions are: distillation temperature 38-46°C, distillation pressure 75-92Pa , the speed of scraping film is 300-320 rpm, the temperature of the condensation surface is 20-25°C, the temperature of the system is 20-25°C, the flow rate of the material is 15-30 ml / hour, and the distillate is obtained, and only the distillate is collected to accumulate enough amount (about 500ml), continue to carry out molecular distillation. The distillation temperature is 48-62°C, the distillation pressure is 35-75Pa, the scraping film speed is 300-320 rpm, the condensation surface temperature is 20-25°C, the system is kept warm at 20-2...

preparation example 2

[0071] Preparation example 2: preparation of extract from zedoary zedoary volatile oil

[0072] According to the same method as Preparation Example 1, replace 1000ml of Sichuan Curcuma volatile oil with 1000ml of zedoary volatile oil (containing about 3wt% curcumone, about 2.88wt% aromatic curcumone and about 6.16wt% gemaconone) to obtain 110ml of gemaconone+ The extract with the total content of curcumone + aromatic curcumone ≥ 70wt%. The product is an extract of Zedoary Curcuma containing about 75wt% of the above three sesquiterpene ketones and about 19wt% of sesquiterpenes (extract B for short).

preparation example 3

[0073] Preparation example 3: Preparation of extract from zedoary laurel essential oil

[0074] According to the same method as Preparation Example 1, replace 1000ml of Chujin turmeric volatile oil with 1000ml of zedoary turmeric volatile oil (containing about 2.85wt% curcumone, about 3.13wt% aromatic curcumone and about 7.00wt% gemaconone) to obtain 110ml of turmeric The extract with the total content of ketone + curcumone + aromatic curcumone ≥ 70wt%. The product is an extract of Curcuma laurel containing about 75wt% of the above three sesquiterpene ketones and about 19wt% of sesquiterpenes (extract C for short).

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Abstract

The present invention relates to the new types of plant extract containing germacrone, curcumone and / or arylcurcumone, that is, nano liposome type, precursor liposome type long-cycle liposome type, long-cycle nano liposome type, nano microemulsion type, venous emulsion type, nano liposome sphere type and fat emulsion type.

Description

Technical field: [0001] The present invention relates to new injectable dosage forms of plant extracts containing sesquiterpene ketones, and more particularly to liposomal, nanoliposomal, proliposomal, and long-circulating liposomal dosage forms of these formulations , long-circulation nanoliposome formulation, nanomicroemulsion formulation, intravenous emulsion formulation, lipid nanosphere formulation and fat emulsion formulation. The invention also relates to methods for the preparation and use of these dosage forms. Background technique: [0002] In recent years, many researchers in the field of anticancer natural medicine research have devoted themselves to studying the anticancer activities of paclitaxel, various isomers of elemene, turmeric extract, turmeric extract, etc., and various preparation forms of these drugs . [0003] Elemene is a sesquiterpene compound present in some plants. The Latin name is Elemenum, the English name is Elemene, and the chemical name i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61K36/9066A61K9/127A61K9/107A61P35/00
Inventor 李德山谢恬
Owner 谢恬
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