Parallel column scanning spectrum type surface plasma resonant imaging method and apparatus

A surface plasmon and row-column scanning technology, applied in the field of refractive index imaging, can solve the problems of slow measurement speed and inability to adapt, and achieve the effects of high efficiency, large information throughput, and high refractive index resolution
CN100483110CInactive Publication Date: 2009-04-29SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
Publication Date
2009-04-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

Its method includes the following steps: changing the beam emitted by broadband light source into a hairline beam; making said hairline beam be irradiated on SPR generation device; after the beam outcome from said device is dispersed, utilizing two-dimensional photoelectric detection device to make detection and obtain SPR spectrum information in a lighted line-type region of tested plane; translating said device and using said hairline beam to scan the whole tested plane to obtain SPR spectrum information of all the columns of whole tested plane; utilizing computer to make operation and processing to obtain refractive index information of whole tested plane in said device so as to form a two-dimensional image. Said method can be used for detecting various biological chips.
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Description

Technical field:

[0001] The invention belongs to the technical field of optical imaging detection, in particular to a refractive index imaging method and device based on column-scanning spectral surface plasmon resonance (SPR) technology. Background technique:

[0002] The surface plasmon resonance (SPR) sensing method has been widely used in the fields of biology and chemistry because of its high sensitivity and label-free characteristics. There have been reports on the use of point-measurement SPR sensing methods to study protein reactions, chemical reactions, etc. (Anal. Chem. 70 (1998) 2019-2024). However, with the widespread application of biological arrays (i.e., biochips) such as gene arrays and protein arrays, the refractive index sensing of points cannot meet the needs of research. . The traditional imaging method using SPR (Nature 332 1988.615-616.), that is, SPM (surface plasmon microscopy), fixes the frequency and incident angle of the incident parallel light b...

Claims

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