Titanium material with biological activity and preparation method thereof

A technology of biological activity and metal titanium, which is applied in the field of bioactive titanium materials and its preparation, can solve the problems of lack of biological activity and high elastic modulus of materials, and achieve improved biological activity, improved biomechanical compatibility, and improved biomechanical properties. compatibility effect

Inactive Publication Date: 2010-01-27
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a preparation method of biologically active titanium materials, which solves the problems of lack of biological activity of titanium materials and high elastic modulus of materials in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1: Metal titanium or titanium alloy powder with a particle size of 5 μm to 100 μm is isostatically pressed and sintered in a vacuum at 1200° C.; the material after powder metallurgy sintering is 0.16mol / L calcium acetate ((CH 3 COO) 2 Ca·H 2 O, CA), 0.04mol / L sodium β-glycerophosphate (C 3 h 7 Na 2 o 6 P·5H 2 O, β-GP) and sodium hydroxide are configured for micro-arc oxidation in electrolytic aqueous solution, and the pH value is adjusted to 5, with titanium material as the anode and stainless steel as the cathode. In the constant voltage mode of the micro-arc oxidation power supply, the selected voltage is 100V, the duty cycle is 30%, and the frequency is 800Hz. The prepared material has biological activity and good biomechanical compatibility.

Embodiment 2

[0011] Example 2: Metal titanium or titanium alloy powder with a particle size of 5 μm to 100 μm is isostatically pressed and sintered in vacuum at 1300° C.; the material after powder metallurgy sintering is 0.2mol / L calcium acetate ((CH 3 COO) 2 Ca·H 2 O, CA), 0.01mol / L of β-sodium glycerophosphate (C 3 h 7 Na 2 o 6 P·5H 2 O, β-GP) and sodium hydroxide are configured for micro-arc oxidation in electrolytic aqueous solution, and the pH value is adjusted to 5.8, with titanium material as the anode and stainless steel as the cathode. In the constant voltage mode of the micro-arc oxidation power supply, the selected voltage is 500V, the duty cycle is 10%, and the frequency is 200Hz. The prepared material has biological activity and good biomechanical compatibility.

Embodiment 3

[0012] Example 3: Metal titanium or titanium alloy powder with a particle size of 5 μm to 100 μm is isostatically pressed and sintered in vacuum at 1100° C.; the material after powder metallurgy sintering is 0.4mol / L calcium acetate ((CH 3 COO) 2 Ca·H 2 O, CA), 0.04mol / L sodium β-glycerophosphate (C 3 h 7 Na 2 o 6 P·5H 2 O, β-GP) and potassium hydroxide are configured for micro-arc oxidation in electrolytic aqueous solution, and the pH value is adjusted to 7, with titanium material as the anode and stainless steel as the cathode. In the constant voltage mode of the micro-arc oxidation power supply, the selected voltage is 350V, the duty cycle is 40%, and the frequency is 1000Hz. The prepared material has biological activity and good biomechanical compatibility.

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Abstract

The invention relates to a method for preparing biologically active titanium materials, which is characterized in that the method includes the steps as follows: (1) metal titanium or titanium alloy powder and the like of 5 microns to 100 microns are pressed statically for shaping and then sintered in vacuum at the temperature of 1100 DEG C to 1300 DEG C; (2) microarc oxidation treatment is conducted on the materials after powder matallurgy is sintered in electrolytic aqueous solution prepared by calcium acetate, natrium glycerophosphoricum and hydroxide to obtain the biologically active titanium materials. The obtained titanium materials contain pores internally; the surface of the titanium material shows the complex porous state and has two states of the pores, one is microarc oxidation pore and the other one is large pore formed by the powder metallurgy with the microarc oxidation pore on the inside wall. The biological activation and biomechanical compatibility of the surface of the obtained titanium materials are higher than those of the titanium materials obtained by the single powder metallurgy method. The preparing method of the invention can be used for preparing the biological replacement (recovery) body for hard tissues such as human bones, teeth, etc.

Description

technical field [0001] The invention relates to a biomedical metal matrix composite material, in particular to a bioactive titanium material and a preparation method thereof. Background technique [0002] At present, most of the replacement (restoration) materials for biological hard tissues such as human bones and teeth are rolled or cast titanium materials. Titanium materials have the characteristics of corrosion resistance, high strength and biocompatibility. However, the elastic modulus of rolled or cast titanium materials is significantly higher than that of human bone, thus reducing the biomechanical compatibility of materials and limiting the application of titanium materials. The titanium material prepared by the powder metallurgy method has an appropriate amount of pores, which reduces the elastic modulus of the material and improves the biomechanical compatibility of the material. However, the biological activity of titanium materials prepared by powder metallurgy...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): B22F3/12B22F3/24C22C1/04C22C14/00C25D11/26A61L27/42A61L27/06A61L27/30
Inventor李卫刘英
OwnerJINAN UNIVERSITY