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Substituted andrographolide derivative, preparing method and pharmaceutical compound thereof

A technology for dehydrating andrographis paniculata and saponifolactam, which can be used in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve problems such as unseen

Inactive Publication Date: 2010-12-15
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report in the existing literature about the activity of andrographolide derivatives to inhibit the expression of COX-2, TNF-α and IL-6

Method used

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  • Substituted andrographolide derivative, preparing method and pharmaceutical compound thereof
  • Substituted andrographolide derivative, preparing method and pharmaceutical compound thereof
  • Substituted andrographolide derivative, preparing method and pharmaceutical compound thereof

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Abstract

The invention discloses a compound and medical acceptable salt with general formula (I) and making method and their drug agent, which possesses better COX-2 expressive inhibiting and TNF-alpha inhibiting and IL-6 inhibiting action.

Description

technical field The present invention relates to substituted andrographolide derivatives, their synthesis methods, and pharmaceutical compositions containing them. Background technique Andrographolide is one of the main active ingredients of Andrographis paniculata (Burm.f.) Nees, a plant of the Acanthaceae family. Antipyretic, anti-inflammatory (Deng Wenlong, et al. Acta Pharmaceutica Sinica, 1980, 15(10): 590), analgesic, antibacterial (Xu Luoshan et al., Chinese Materia Medica (Volume 2). Beijing: China Medical Science and Technology Press, 1996: 1580), hypoglycemic, anti-atherosclerosis and other extensive physiological activities, it is mainly used clinically to treat diseases such as upper respiratory tract infection. With the continuous deepening of the research on the pharmacological effects of andrographolide, it has shown attractive application prospects in immune regulation, anti-virus, anti-tumor and other aspects. (Dai Guifu, Wang Junfeng, He Shuaiwei, etc. Ch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/58C07D407/12C07D207/277A61K31/365A61K31/4015A61P43/00
Inventor 黄文龙张惠斌李晶周慧萍
Owner CHINA PHARM UNIV
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