Sarcandra glabra effective constituent, preparation method thereof, medicament composition and use of the same

A composition and drug technology, applied in the direction of drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as unclear mechanism of action, unclear active ingredients, unstable curative effect, etc.

Inactive Publication Date: 2007-10-24
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the active ingredients and mechanism of traditional Chinese medicine compound preparations currently used in clinical practice are not clear, and the curative effect is not stable, which seriously affects the clinical use and the entry of traditional Chinese medicine into the international mainstream market. Drugs are an urgent task for medical researchers for a long time to come

Method used

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  • Sarcandra glabra effective constituent, preparation method thereof, medicament composition and use of the same
  • Sarcandra glabra effective constituent, preparation method thereof, medicament composition and use of the same
  • Sarcandra glabra effective constituent, preparation method thereof, medicament composition and use of the same

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0078] Experimental example 1 In vitro study on the protective effect of the compound of the present invention on D-GalN-induced WB cell death

[0079] group

concentration

OD 492

Cell viability (%)

normal

D-GalN model

bicyclol

+GalN

5

+GalN

1

+GalN

14

+GalN

19

40mM

1×10 -4 m

40mM

5μg / ml

40mM

5μg / ml

40mM

5μg / ml

40mM

5μg / ml

0.805±0.047 **

0.454±0.031

0.773±0.090

0.519±0.030 **

0.775±0.021

0.529±0.024 **

0.894±0.084

0.521±0.010 **

0.755±0.041

0.467±0.027 *

0.784±0.038

100

56

60

66

65

58

+GalN

40mM

0.545±0.035 **

68

group

concentration

OD 492

Cell viability (%)

normal

D-GalN model

bicyclol

+...

experiment example 2

[0082] Experimental example 2 In vitro study on the protective effect of compounds of the present invention on APAP-induced WB cell death

[0083] group

concentration

OD 492

Cell viability (%)

normal

APAP model

bicyclol

+APAP

25mM

1×10 -4 m

25mM

0.734±0.046 **

0.513±0.020

0.760±0.095

0.61 1±0.024 **

100

70

83

5

+APAP

1

+APAP

19

+APAP

5μg / ml

25mM

5μg / ml

25mM

5μg / ml

25mM

0.727±0.038

0.569±0.029 **

0.816±0.057

0.617±0.030 **

0.790±0.118

0.592±0.054 **

78

84

81

group

concentration

OD 492

Cell viability (%)

normal

APAP model

bicyclol

+APAP

16

+APAP

18

+APAP

25mM

1×10 -4 m

25mM

5μg / ml

...

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PUM

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Abstract

The invention discloses a making method of four new substituted phenyl flavonols (1-4) compound, eight new sesquiterpenoids (5-12), one new dihydrochalcone (13) and eight known compound (14-21), which contains drug composition with effective component of sarcandra glabra as well as the application in the liver-damage protecting drug.

Description

technical field [0001] The invention discloses four new phenylpropanoid-substituted flavanol glycosides (1-4) compounds, eight new sesquiterpenoids (5-12), A preparation method of a new dihydrochalcone compound (13) and eight known compounds (14-21), a pharmaceutical composition containing the active ingredients of Corydalis praecox, and their application in the preparation of drugs for protecting liver damage. Background technique [0002] Grass coral is the whole plant of Sarcandra glabra (Thunb.) Nakai. It can clear away heat and detoxify, expel wind and activate blood circulation, reduce swelling and pain, antibacterial and anti-inflammatory. Indications for influenza, Japanese encephalitis, pneumonia, appendicitis, pelvic inflammatory disease, bruises, rheumatic joint pain, amenorrhea, wound infection, dysentery, etc. In the past ten years, hepatitis B has spread widely in my country, and the average carrier rate of hepatitis B virus is 10%. About 300,000 people die of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H15/26C07D307/77C07J9/00A61K31/7048A61K31/704A61K31/365A61P1/16A61K36/185
Inventor 张东明李燕李媛李烨李建北陈晖杨敬芝
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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