Sarcandra glabra effective constituent, preparation method thereof, medicament composition and use of the same
A composition and drug technology, applied in the direction of drug combinations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as unclear mechanism of action, unclear active ingredients, unstable curative effect, etc.
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experiment example 1
[0078] Experimental example 1 In vitro study on the protective effect of the compound of the present invention on D-GalN-induced WB cell death
[0079] group
concentration
OD 492
Cell viability (%)
normal
D-GalN model
bicyclol
+GalN
5
+GalN
1
+GalN
14
+GalN
19
40mM
1×10 -4 m
40mM
5μg / ml
40mM
5μg / ml
40mM
5μg / ml
40mM
5μg / ml
0.805±0.047 **
0.454±0.031
0.773±0.090
0.519±0.030 **
0.775±0.021
0.529±0.024 **
0.894±0.084
0.521±0.010 **
0.755±0.041
0.467±0.027 *
0.784±0.038
100
56
60
66
65
58
+GalN
40mM
0.545±0.035 **
68
group
concentration
OD 492
Cell viability (%)
normal
D-GalN model
bicyclol
+...
experiment example 2
[0082] Experimental example 2 In vitro study on the protective effect of compounds of the present invention on APAP-induced WB cell death
[0083] group
concentration
OD 492
Cell viability (%)
normal
APAP model
bicyclol
+APAP
25mM
1×10 -4 m
25mM
0.734±0.046 **
0.513±0.020
0.760±0.095
0.61 1±0.024 **
100
70
83
5
+APAP
1
+APAP
19
+APAP
5μg / ml
25mM
5μg / ml
25mM
5μg / ml
25mM
0.727±0.038
0.569±0.029 **
0.816±0.057
0.617±0.030 **
0.790±0.118
0.592±0.054 **
78
84
81
group
concentration
OD 492
Cell viability (%)
normal
APAP model
bicyclol
+APAP
16
+APAP
18
+APAP
25mM
1×10 -4 m
25mM
5μg / ml
...
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