Methods and means for diagnostics, prevention and treatment of mycobacterium infections and tuberculosis disease

A kind of technology of mycobacteria and composition, applied in the field of mycobacterial disease

Inactive Publication Date: 2008-06-18
莱顿大学医药中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention solves the above-discussed problems by in vivo identification of dominant human immune responses to mycobacterial latency-associated antigens and / or epitopes thereby providing new methods and methods for detection and immunization against latent mycobacterial infection. combination

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  • Methods and means for diagnostics, prevention and treatment of mycobacterium infections and tuberculosis disease
  • Methods and means for diagnostics, prevention and treatment of mycobacterium infections and tuberculosis disease
  • Methods and means for diagnostics, prevention and treatment of mycobacterium infections and tuberculosis disease

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Embodiment Construction

[0011] The present invention provides methods and compositions for inducing an immune response to a mycobacterial infection, especially a latent mycobacterial infection, in a vertebrate, preferably a mammal, the method comprising the step of administering to the vertebrate a composition comprising a or a plurality of polypeptides or fragments thereof selected from the group comprising polypeptides encoded by mycobacterial NRP / dormancy (DosR) regulator proteins capable of eliciting an immune response in vivo in a vertebrate having a mycobacterial infection .

[0012] The term mycobacterial infection as used herein is meant to encompass latently infected mammals, ie mammals newly infected that have not yet shown symptoms and vertebrates with mycobacterial induced diseases and symptoms such as active tuberculosis. In order to prevent the development of tuberculosis disease, the mycobacterial infection treated according to the invention is preferably a latent infection. The metho...

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Abstract

The invention identifies a narrow subset of Mycobacterium latency associated antigens and or epitopes that are capable of eliciting an immune response in vivo and in vitro in a mammal. The invention provides methods and compositions for detection and immunization against latent Mycobacterium infections. These compositions comprise those Mycobacterial latency antigens that are actually capable of eliciting an immune response in vivo, in mammals experiencing a latent Mycobacterium infection. More preferably the compositions comprise those antigens that are preferentially recognized by latently infected individuals and which antigens are not, or to a much lesser extent, recognized in individuals having an active Mycobacterium infection or in individuals having Mycobacterium induced symptoms or diseases, such as in patients infected with M. tuberculosis suffering from tuberculosis disease (TB).

Description

field of invention [0001] The present invention relates to the field of medicine, in particular to the diagnosis, prevention and treatment of mycobacterial diseases and more particularly those infections caused by Mycobacterium tuberculosis. The invention also relates to the field of vaccines. Background of the invention [0002] Tuberculosis (TB) is a major threat to global health, with a conservative estimate of four TB deaths per minute, equivalent to two million per year. An estimated one-third of the world's population is latently infected with M. tuberculosis. Most active TB cases originate from this large pool of potential TB disease sources, which is a major obstacle to achieving TB control. [0003] There are several reasons why latent M. tuberculosis infection makes efforts to eradicate TB difficult. First, contact tracing and treatment for latent infection is only available where the vast majority of people have a negative tuberculin skin test, which occurs in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/04
CPCG01N33/5695A61K39/04A61P31/06A61P37/00
Inventor 米切尔·罗伯特·克莱恩民勇·林克莉斯特·伊丽莎白·凡·梅伽登柯勒里·莱奥纳多·玛利亚·克拉特·富兰克恩艾莲·玛德琳·苏菲·雷腾汤姆·亨利库斯·玛利亚·奥登霍
Owner 莱顿大学医药中心
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