23-hydroxy betulinic acid derivative, preparation method, preparation and use thereof

Abstract

The invention relates to modified 23-hydroxybetulinic acid derivative (1), which belongs to the natural medicine and pharmaceutical chemistry field. The definition of R1, R2, and R3 is shown in the instruction. The invention also discloses a preparation method of the 23-hydroxybetulinic acid derivative, the medicine composition containing the 23-hydroxybetulinic acid derivative, and the use thereof in tumor resistance.

Description

23-Hydroxybetulinic acid derivatives, preparation method, preparation and use thereof technical field The present invention relates to the field of natural medicine and medicinal chemistry, in particular to a class of modified 23-hydroxy betulinic acid derivatives. The invention also discloses the preparation method of these 23-hydroxy betulinic acid derivatives, The pharmaceutical composition of the compound and the use of such 23-hydroxy betulinic acid derivatives for anti-tumor. Background technique 23-Hydroxybetulinic acid is a compound similar to betulinic acid in structure. 23-Hydroxybetulinic acid is a pentacyclic triterpenoid compound extracted from the Chinese herbal medicine Pulsatilla chinensis Regel. It has the functions of clearing heat and detoxifying, cooling blood and stopping dysentery, drying dampness and killing insects. Clinically, it is mainly used to treat bacillary dysentery, amoebic dysentery, and gynecological vaginitis. Modern research has found...

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Problems solved by technology

At present, in the field of anti-tumor, most researchers believe that betulinic acid and its derivatives achieve the purpose of anti-tumor by inhibiting angiogenesis, but no such compounds have entered the clinical trial stage for many years

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