Polypeptide combinative with PKR kinase structure field specificity and uses thereof
A kinase domain, specific technology, applied in the direction of peptides, material inspection products, biological tests, etc., can solve the problems of no reports of PKR inhibitors and PKR peptide inhibitors
Inactive Publication Date: 2010-12-01
NANKAI UNIV
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Problems solved by technology
Although the PKR kinase domain plays a role in diseases such as Alzheimer's disease, there are no reports of PKR inhibitors and PKR polypeptide inhibitors
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The invention relates to a polypeptide capable of specifically binding with the structural domain of PKR kinase and an application thereof. The invention relates to a 12-peptide sequence with amino acid sequence of Ser-Val-His-Leu-Tyr-His-Ser-Thr-Lys-Thr-Leu-Arg, which is capable of specifically binding with the PKR kinase structural domain (PKRcat) and inhibiting the activity of the PKR kinase. Therefore, the 12-peptide has practical value in research on the role of PKRcat in cell apoptosis and development of PKRcat inhibitors.
Description
Polypeptide specifically binding to PKR kinase domain and application thereof technical field The invention belongs to the technical field of bioengineering and biomedicine, and relates to the use of phage display technology to screen a polypeptide capable of specifically combining with a PKR kinase domain (PKRcat) and an application thereof. Background technique PKR is an interferon-induced double-stranded RNA-dependent protein kinase and a member of the eukaryotic translation initiation factor eIF2α kinase family. It is a serine-threonine kinase composed of 551 amino acids, and recent studies have also found that it has tyrosine kinase activity [Su, Q. et al. Structurally, it mainly includes two functional domains: the N-terminal and RNA-binding regulatory domain and the C-terminal catalytic domain. PKR plays a major role in the interferon-induced antiviral defense response and is considered to be the most characteristic antiviral pathway induced by IFN. PKR may also ...
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IPC IPC(8): C07K7/08G01N33/68
Inventor 曹又佳张宏恺常云松杜明娟张翠竹
Owner NANKAI UNIV
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