The invention discloses essence with effects of whitening, defying age and activating skin and a preparation method of the essence. The essence comprises the following components: a wetting agent, acrylic (acrylate)/C10-30 alkyl acrylate crosslinked polymers, 2-oleamido-1,3-octodecanediol, mulberry bark extract, irkutsk anemone rhizome extract, persimmon leaf extract, growth-factor-containing lipidosome, capryloyl salicylic acid, cholesterol polyether-24, a thickening agent, a preservative and the balance of deionized water. The essence with effects of whitening, defying age and activating skin disclosed by the invention is scientific in ratio of various components, the various components achieve obvious synergistic effects, and the essence can achieve the effects of efficiently moisturizing, supplying nutrition to skin, promoting skin metabolism, reducing stains, effectively removing lines and wrinkles, retarding skin aging, improving skin sagging, brightening and tightening skin, moisturizing for a long time, enabling the skin to be moisturized, smooth and enriched in elasticity and improving the skin youth.