Flavonoid derivative , preparation method thereof and use thereof

Abstract

The invention relates to polyphenols substances, a synthesis method thereof and the use thereof, in particular to a flavonoid derivative, a preparation method thereof and the use thereof, and solves the problem that the conventional natural flavonoids compounds are difficult to extract and obtain and cannot be widely used. The structural formula (I) of an intermediate and the structural formula (II) of a final product are shown below, wherein R1, R2 and R3 are respectively selected from hydrogen, C1-C8 alkyl, halogen, nitro, C1-C8 alkoxy and amino; and R1, R2 and / or R3 can be fused with a benzene ring to form a substituted or unsubstituted fused ring compound; R4 and R5 are respectively selected from C1-C8 alkyl, C1-C8 alkoxy and alkylene; R may be H, methoxy-methoxy or methoxy; and b ring is a benzene ring or a heterocyclic compound. The derivative can be used for preparing medicaments for resisting tumors and cardiovascular and cerebrovascular diseases and inhibitors of protein tyrosine kinases, opens up a new way for preparing the medicaments and brings a new breakthrough to the medicament field; and the synthesis method has the advantages of mild condition and convenient operation.

Description

technical field The invention relates to polyphenolic substances and their synthesis method and application, specifically a flavonoid derivative and its preparation method and application. Background technique Flavonoids (flavonoids) are a class of low-molecular-weight polyphenols, mostly internal signal molecules and intermediates, widely distributed in nature, and exist in plants in the form of free or sugar-bound glycosides. The secondary metabolites produced in the process are mostly yellow. It has a wide range, including flavone, flavanone, isoflavone, chaclone and so on. These compounds have various biological activities and pharmacological effects such as scavenging free radicals, anti-oxidation, anti-cancer, anti-bacterial, anti-allergy, anti-inflammation, anti-virus, etc., and are also of great significance to the prevention and treatment of human tumors and cardiovascular diseases . However, since flavonoids are a class of low-molecular-weight natural plant com...

AI Technical Summary

Problems solved by technology

In order to solve the problems that the existing natural flavonoids are difficult to extract, not easy to obtain, and cannot be widely used, the present invention provides a flavonoid derivative and its preparation method and use

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