Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A heteroaryl and heterocyclyl technology, applied in the field of compounds that regulate the function of HPK1, can solve the problems that surgical resection is not feasible and damages cells
Active Publication Date: 2020-01-10
F HOFFMANN LA ROCHE & CO AG
View PDF11 Cites 5 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Unfortunately, for many tumors or forms of cancer, surgical removal is not a viable option
In addition, radiation therapy and chemotherapy drugs do not target only diseased cells, thus ultimately damaging healthy cells
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0798] At -78°C, N 2 , to a solution of 2,6-dichloro-3-iodo-pyridine (13.69 g, 50 mmol) in anhydrous THF (150 mL) was added LDA (2.0 M in THF, 27.5 mL, 55 mmol) dropwise. After the addition was complete, the reaction solution was stirred at -78°C for 2 hours. in CO 2 After bubbling for 5 minutes, the reaction mixture was stirred at room temperature for 2 hours. The reaction solution was quenched with concentrated HCl, and extracted with dichloromethane. The combined organic layers were in Na 2 SO 4 Drying on , filtered and concentrated gave 2,6-dichloro-4-iodo-pyridine-3-carboxylic acid (8.1 g, 51% yield) as a light yellow solid. LCMS(ESI)[M+H] + = 317.8.
[0826] To the vial add tert-butyl N-(6,8-dichloro-2,7-naphthyridine-3-yl)carbamate (1.05 g, 3.34 mmol), HCl / 1,4-dioxane (10 mL, 4N, 40 mmol) and dichloromethane (5 mL). The mixture was stirred at 40°C for 4 hours. The mixture was concentrated and dried in vacuo to give 6,8-dichloro-2,7-naphthyridine hydrochloride (823 mg, 96% yield) as a yellow solid. LCMS(ESI)[M+H] + = 214.1.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
particle diameter
aaaaa
aaaaa
Login to view more
Abstract
Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods ofinhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
Description
[0001] Cross References to Related Applications [0002] This application claims priority to International Patent Application No. PCT / CN2017 / 078792, filed March 30, 2017, and International Patent Application No. PCT / CN2018 / 076909, filed February 15, 2018, the contents of which are incorporated by reference in their entirety Incorporated into this article. [0003] sequence listing [0004] This application contains a Sequence Listing, which has been filed electronically in ASCII format, and is hereby incorporated by reference in its entirety. Said ASCII copy, created on March 26, 2018, is named P34139_WO_2_SL.TXT and is 21KB in size. technical field [0005] The present invention relates to compounds that modulate the function of HPK1, which are useful in the treatment of diseases and conditions mediated by HPK1, such as cancer. Background technique [0006] The main treatments that oncologists use to treat cancer are surgical resection, radiation therapy, and classic che...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more