Use of apoptosis-specific eif-5a sirna to down regulate expression of proinflammatory cytokines to treat sepsis

A pro-inflammatory cytokine and sepsis technology, applied in the direction of DNA / RNA fragments, recombinant DNA technology, etc., can solve the problem of not providing ribonuclease protection

Inactive Publication Date: 2009-03-11
SENESCO TECHNOLOGIES INC
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In addition, the high lysine residues of modified eIF-5A are important for sequence-s

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  • Use of apoptosis-specific eif-5a sirna to down regulate expression of proinflammatory cytokines to treat sepsis
  • Use of apoptosis-specific eif-5a sirna to down regulate expression of proinflammatory cytokines to treat sepsis
  • Use of apoptosis-specific eif-5a sirna to down regulate expression of proinflammatory cytokines to treat sepsis

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[0046] [45] Several eukaryotic initiation factor isoforms 5A ("eIF-5A") have been isolated and included in publicly available databases. These isoforms are thought to be functionally redundant. The present inventors found that there is a subtype that is up-regulated immediately before the induction of apoptosis, and the inventors named the subtype apoptosis-specific eIF-5A or eIF-5A1. The object of the present invention is apoptosis-specific eIF-5A, and down-regulating its expression to down-regulate the expression of pro-inflammatory cytokines.

[0047] [46] Sepsis is a malignant intravascular inflammation that causes approximately 210,000 deaths per year. Therefore, adjuvant therapy is required. Sepsis is also known as systemic inflammatory response syndrome (SIRS). Sepsis is caused by a bacterial infection that can spread throughout the body. Sepsis can be simply identified as a spectrum of clinical conditions resulting from a patient's immune response to inflammation, ...

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Abstract

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock.

Description

[0001] Cross References to Related Applications [0002] [01] The application claims the priority of U.S. Provisional Patent Application 60 / 79833 filed on May 8, 2006 and U.S. Provisional Patent Application 60 / 783,413 filed on March 20, 2006, and the two U.S. Provisional Patent Applications The entire content of the application is incorporated herein by reference. technical field [0003] [02] The present invention relates to apoptosis-specific eukaryotic initiation factor ("eIF-5A") - alternatively referred to as "apoptosis-specific eIF-5A" or "eIF-5A1", and the use of anti-eIF-5A1 siRNA to downregulate the expression of pro-inflammatory cytokines. Background technique [0004] [03] Apoptosis is a genetically determined cellular event characterized by distinct morphological features, such as cell shrinkage, chromatin condensation, nuclear fragmentation, and membrane blebbing. Kerr et al. (1972) Br. J. Cancer, 26, 239-257; Wyllie et al. (1980) Int. Rev. CytoL, 68, 251-306....

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Application Information

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IPC IPC(8): C12N15/11
Inventor J·E·汤普逊
Owner SENESCO TECHNOLOGIES INC
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