4results about How to "Prevent sepsis" patented technology

The invention provides heat-resistant bacillus pumilus P2-7 and application thereof in disease prevention and control of prawn culture, and belongs to the technical field of bioengineering. The heat-resistant bacillus pumilus P2-7 provided by the invention is preserved in Guangdong Microbial Culture Collection Center on November 4, 2024, and the preservation number of the heat-resistant bacillus pumilus P2-7 is GDMCC NO. 65408. The strain is different from the traditional antibacterial bacillus in antagonism mode, cannot secrete metabolites with antibacterial activity, plays a role in a phagocytosis mode, can remarkably remove / inhibit pathogenic bacteria in water, can effectively prevent and control shewanella disease of prawns, and has a good application prospect. The composition also has a good effect of simultaneously preventing septicemia, acute hepatopancreas necrosis, white spot syndrome and infectious subcutaneous and hematopoietic necrosis in prawn culture production.

The application belongs to the technical field of biological probes, and relates to a PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe and a preparation method thereof. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe comprises a core, a covalent organic framework and a PD-L1 antibody, the core comprises a superparamagnetic nanoparticle, the covalent organic framework is coated on the surface of the core, and the PD-L1 antibody is combined on the surface of the covalent organic framework. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe prepared by the application can be transported into the body across the membrane, smoothly enter a PD-L1 positive malignant tumor lesion, and perform Raman imaging to microscopically distinguish the tumor boundary.

This invention provides a thermoresistant Bacillus pumilus P2-7 strain and its application in the prevention and control of diseases in shrimp farming, belonging to the field of bioengineering technology. The thermoresistant Bacillus pumilus P2-7 strain provided by this invention was deposited at the Guangdong Provincial Microbial Culture Collection Center on November 4, 2024, with accession number GDMCC NO.65408. This strain differs from traditional antibacterial Bacillus strains in its antagonistic mechanism; it does not secrete metabolites with antibacterial activity, but rather exerts its effects through phage therapy. It can significantly eliminate / inhibit pathogenic bacteria in water and effectively control Shevax disease in shrimp. It also shows good efficacy in simultaneously preventing septicemia, acute hepatopancreatic necrosis, white spot syndrome, and infectious hypodermal and hematopoietic tissue necrosis in shrimp farming.

The invention relates to a burn dressing capable of preventing sepsis and a preparation method thereof. The dressing can be obtained through an extremely simple technological process, the imbibition / excipient, the antibacterial agent, the lipopolysaccharide inhibitor, the rheology regulator, the pH regulator, the osmotic pressure regulator, the humectant and other components can be directly dissolved in water to be mixed, packaged and sterilized, and then the dressing can be applied to promoting healing of burn wounds. While the antibacterial effect is achieved, signal transmission of lipopolysaccharide is inhibited by capturing lipopolysaccharide or competitively combining lipopolysaccharide receptors, and therefore sepsis mainly caused by lipopolysaccharide is prevented. The method is expected to play a positive promotion role in saving the life of a serious burn patient and relieving the burden of social and medical systems.