35results about How to "Prevent sepsis" patented technology

Devices and methods are disclosed for measuring a pre-defined period as a method to alert medical personnel of the need for clinical intervention. Many invasive and non-invasive medical procedures require constant monitoring or intervention. Failure to properly observe or intervene may result in clinical harm. The devices and methods disclosed herein are useful in any field of medicine where periodic monitoring or procedures are required. The devices is designed to be familiar to medical personnel, and in its most common form will be packaged as a band aid, but may also be packaged as a coin sized device that adheres to or clips onto a patient's bandage, limb, or on a necklace. The timer provides an audible warning of timeout, a visual indication of timeout, a tactile indication or any combination of the three. The number of hours in the countdown sequence is variable and determined from a series of choices provided to the caregiver. The device can be used to monitor temperature and warn of an infection.

The invention relates to the field of immunology. Specifically, the invention relates to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease or inflammatory disease. The invention provides for an immunoregulator (IR), use of an IR in preparing a pharmaceutical composition for treating an immune-mediated disorder and a method for treating an immune-mediated disorder.

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.

The invention relates to the field of immunology. Specifically, the invention relates to the field of immune-mediated disorders such as allergies, auto-immune disease, transplantation-related disease or inflammatory disease. The invention provides for an immunoregulator (IR), use of an IR in preparing a pharmaceutical composition for treating an immune-mediated disorder and a method for treating an immune-mediated disorder.

The invention relates to a traditional Chinese medicine for treating burn wounds by adopting a dry exposed therapy, which belongs to the field of traditional Chinese medicine. The traditional Chinese medicine is prepared from 10 to 20g of calcined plaster, 10 to 20g of dragon bone, 20 to 30g of catechu, 10 to 20g of lithospermum, 10 to 20g of angelica, 10 to 20g of rhizoma atractylodis, 10 to 20g of honeysuckle, 10 to 20g of Sanguisorba officinalis, 10 to 20g of angelica dahurica, 5 to 15g of Ampelopsis japonica, 10 to 20g of frankincense, 10 to 20g of myrrh, 20 to 40g of dragon blood, 10 to 20g of indigo naturalis, 10 to 30g of borneol, 200 to 400g of sesame oil, and 60 to 80g of beeswax. The traditional Chinese medicine has the characteristics of short treatment course, quick effect, low cost, small pain, invulnerability to infection, no scars after healing and so on. Proven by thousands of patients, the effective rate reaches 100 percent, and the cure rate reaches 100 percent.

The invention relates to a quinazoline derivative as a pgk1 (phosphoglycerate kinase 1) activator. Specially, the invention relates to application of the compound shown in formula I or pharmaceutically-acceptable salts, solvates, esters and prodrugs thereof in preparing medicines as pgk1 activators, or in preparing medicines for treating and / or preventing hyperglycemia, cerebral thrombosis and complications thereof, wherein the substituents are indicated as in the specification.

The present invention relates to a method for preparing a purified extract of Lonicera Japonica THUNBERG and the composition comprising the same for preventing and treating sepsis and septic shock. The purified extract of purified extract of Lonicera Japonica THUNBERG potent ant-sepsis activity in severe sepsis CLP model test, the effect on MODS, and the inhibitory effect on various pro-inflammatory cytokines such as TNF-alpha, IL-1beta, IFN-gamma, HMGB-1 etc, as well as it showed unexpectedly synergistic effect on the treatment of sepsis and septic shock in case of combining with the commercially available anti-septic agent such as broad-spectrum anti-biotic to the person skilled in the art, therefore, it can be useful in treating and preventing the sepsis and septic shock as a medicament and health functional food.

The invention is a Chinese patent medicine special for curing large area burn, its character lies in: its ingredients and prescription is: muskiness 30-100g, blood turtle shell 50-600g, climbing fern stem 30-300g, Chinese goldthread 100-800g, carbonized sanguisorba root50-300g, pearl 50-400g, lotus 300-1000g, sow vine root 50-500g, rhubarb 30-100g, asket fern carbon 50-300g, silkworm moth 50-500g, litharge50-300g, radix trichosanthis 30-600g, giant knotweed 30-150g, borneol 30-200g, crude liquorice 30-400g, bark of amur corktree 30-200g, human hair 100-500g, fresh centipede 100-500g, sesame oil 1000-3000g.

The invention relates to the technical field of solid beverages, and discloses an active probiotic solid beverage formula and a preparation method thereof. The invention solves the technical problemsof poor effect and short shelf life of present probiotic beverages. The active probiotic solid beverage is prepared from the components in parts by weight: 20-30 parts of lactitol, 15-25 parts of fructo-oligosaccharide, 15-25 parts of erythritol, and 10-20 parts of maltodextrin, 5-10 parts of acerola cherry powder, 2-8 parts of whey protein powder, 5-10 parts of compound probiotic powder and 1-3 parts of stachyose. According to the technical scheme, a new formula is provided and comprises lactitol, fructo-oligosaccharide, erythritol, maltodextrin, acerola cherry powder, whey protein powder, compound probiotic powder and stachyose, so that the purposes of improving the probiotic effect of the probiotic beverage and prolonging the shelf life of the solid beverage are achieved.

The invention relates to a preparation for spraying and application thereof, in particular to a bacillus subtilis preparation for spraying and application thereof. The problems to be solved are that existing burn treating medicines have tolerance, and a bacillus subtilis preparation is low in survival rate, poor in membrane forming effect and hemostatic effect and single in effect when applied to burn treatment. The bacillus subtilis preparation for spraying comprises bacillus subtilis, 85-94% of nutrient solution, 5-10% of glycerol and 1-5% of dispersant and is used for resisting bacterial infection of burns. The bacillus subtilis (BS224) preparation for spraying serves as a biological barrier and has an antibacterial effect on wound surfaces of the burns by implanting dominant bacteria into the wound surfaces to form a bacterial membrane rapidly and by the aid of biological antagonism.

The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat / prevent sepsis and / or hemorrhagic shock.

The invention relates to a quinazoline derivative and application of serving as a cell apoptosis inhibitor. In particular, the invention relates to a compound of formula I or pharmaceutically acceptable salt, solvate, ester and prodrug of the compound of formula I, wherein each symbol is as described in specification. The compound of the formula I, disclosed by the invention is an effective cell apoptosis inhibitor and can be used for treating and / or preventing cerebral thrombosis and complications of the cerebral thrombosis.

The invention relates to a method for treating sepsis, in particular to application of compounds in a formula I and pharmaceutically acceptable salts, solvates, esters and prodrugs of the compounds in preparation of medicines for treating and / or preventing sepsis and complications thereof. In the formula, substituent groups are described in the specifications.

The invention discloses a formula and production technology of gentle moistening super fruit-flavored yogurt. The formula comprises the following raw materials in parts by weight of 950-975 parts of raw milk, 6-22 parts of whey protein, 1.5-2.5 parts of gelatin, 1-2.5 parts of pectin, 0.5-0.9 part of acetylated distarch phosphate, 15-20 parts of fruit granules, 0.2-1 part of a thickening agent, 0.5-0.6 part of a stabilizing agent and 0.3-0.5 part of cranberry fruit powder. The production technology comprises the following steps of S1, taking the raw milk, the whey protein, the gelatin, the pectin and the acetylated distarch phosphate in parts by weight, and performing mixing treatment so as to obtain samples A; S2, performing mixing treatment on the fruit granules, the thickening agent andthe cranberry fruit powder so as to obtain samples B; and S3, mixing 90% of the samples A with 10% of the samples B, and performing filling. According to the formula and the production technology disclosed by the invention, under the premise that the mouth feel of products is guaranteed, the cranberry fruit powder and cranberry fruit granule jam are added, and the content of anthocyan in the yogurt is reinforced, so that the gentle moistening super fruit-flavored yogurt can have the effects of preventing sepsis, soothing and reducing pressure, increasing the health of the urinary tract, resisting bacteria, resisting inflammation, guaranteeing the health of the intestinal tract and the like.

The invention belongs to the technical field of medical preparations, and particularly discloses a skin disinfection spray preparation, which is prepared from the following raw materials in parts by weight: 10-15 parts of parachlorometaxylenol, 25-45 parts of purple flower bark, 25-45 parts of delavay dobinea root, 30-39.8 parts of catechu, ethanol, 7.5-10 parts of radix scutellariae, 10-12 parts of cortex phellodendri, 5-12 parts of liquorice root, a film-forming agent, 10-12 parts of phospholipid, 2-5 parts of cholesterol, castor oil, chloroform and water. The skin disinfection spray preparation provided by the invention is good in patient compliance and good in sterilization and disinfection effects.

A medicine for treating burning ambustion is prepared by the following Chinese herbal medicine materials by weight, of 30g of savatier monochasma herb, 40g of beautyberry leaf, 30g of receptaculum nelumbinis, 80g of garden burnet, 20g of coptis chinensis, 30g of rheum officinale, 40g of ossa draconis, 40g of scutellaria baicalensis and 50g of elephant hide. The medicine is rapid in pain relieving effects, good in pain relieving effects, good in recovery effects, short in treatment time, capable of effectively avoiding bacterium infection and other diseases, capable of invigorating the circulation of blood and promoting granulation, free of scars after recovery, good in using effects, wide in using scope, and favorable for popularization.

The invention provides application of cholesterol sulfate in preparation of a medicine for preventing sepsis. Animal experiments prove that the cholesterol sulfate sodium salt can effectively prevent sepsis and complications thereof, protect the liver, the kidney, the lung and the heart, and remarkably reduce the level of TNF-alpha and IL-6 main inflammatory factors in serum of sepsis mice, so that the cholesterol sulfate sodium salt has an obvious protection effect on the body, and can be used for preventing sepsis and complications thereof. The survival rate and the survival time of sepsis mice can be remarkably improved and prolonged by injecting the cholesterol sulfate sodium salt. In general, the cholesterol sulfate provided by the invention has a good application prospect in the aspect of sepsis prevention.

The invention discloses baby rabbit healthcare sand, belonging to the technical field of livestock breeding healthcare and disease prevention and control. The baby rabbit healthcare sand is composed of the following components in parts by weight: 20-30 parts of salicylic acid, 15-25 parts of compound sulfamethoxazole, 15-25 parts of calcium propionate and 920-950 parts of talcum powder. The baby rabbit healthcare sand disclosed by the invention is simple in preparation method, wide in raw material resources, capable of effectively preventing newborn rabbit yellow urine disease, septicopyemia, dermatomycoses and dysentery and also capable of effectively treating the diseases to greatly improve the survival rate of baby rabbits, the baby rabbit healthcare sand is a composition with low cost and high prevention and treatment efficiency, and the rabbit disease treatment costs of rabbit warrens are saved.

It is an object of the present invention that the novel nicotinic receptor antagonists disclosed herein may be used in a broad array of clinical or medicinal facets. For example, it is a contemplated use of the present invention that the novel nicotinic receptor antagonists be used to inhibit the growth cycle of non-small cell lung cancer cells. Without being bound by theory, it is an object of the present invention that the nicotinic receptor antagonists disclosed herein are believed to possess reversible binding properties. Moreover, the compounds of the present invention are selective for 0.7 nAChR. For example, the compounds of the present invention are not believed to bind to 0.4 (32 nAChR neuromuscular receptors. It is also contemplated that the nicotinic receptor antagonists of the present invention will be used as a counter measure to treat exposure, or potential exposure, to a wide array of potential neurotoxins.

The invention discloses a composite feed for breeding finless eels. The composite feed comprises, by weight, 10-50 parts of Panax Notoginseng, 5-25 parts of honeysuckle flowers, 4-16 parts of elm bark, 4-18 parts of Saccharomyces cerevisiae, 7-21 parts of a hungry promoter, 5-15 parts of blood globulin powder, 4-16 parts of a mildew inhibitor, 7-21 parts of choline, 4-16 parts of roe powder, 5-25parts of Aristolochia contorta Bunge, 3-13 parts of oriental blueberry leaves, 4-18 parts of lyophilized probiotic powder, 3-13 parts of Clanos bilineata walker powder, 3-21 parts of isomaltooligosaccharides, 7-21 parts of chicken's gizzard membrane, 5-25 parts of rheum officinale, 3-21 parts of Radix Polygalae, 2-14 parts of potassium iodate and 2-12 parts of methionine. The composite feed has the advantages of promotion of the growth of finless eels, and promotion of digestion.

The invention discloses an electuary for treating nonspecific vaginitis, wherein the electuary comprises, by weight, 15-20 parts of green lemons, 10-15 parts of apricots, 4-7 parts of cortex phellodendri, 8-12 parts of fructus lycii, 5-10 parts of eucalyptus globules, 8-12 parts of fresh aloe, 4-8 parts of sophora flavescens, 4-6 parts of atractylodes macrocephala, 4-7 parts of radix scutellariae, 2-4 parts of radix polygonum divaricatum, 6-8 parts of hemistepta lyrata, 3-5 parts of fructus arctii, 2-4 parts of gomphostemma arbusculum, 4-7 parts of gentiana scabra, 8-12 parts of chrysanthemum indicum, 3-5 parts of honey-fried licorice roots, 10-14 parts of lentinula edodes, and 35-55 parts of an auxiliary filling agent. The electuary has a safe formula and has no toxic and side effects, can effectively treat the nonspecific vaginitis and quickly alleviate the disease, and meanwhile prevents complications, such as septicemia.

The invention discloses application of piperine to the preparation of drugs for preventing and treating septicemia. Piperine can strongly enhance the leucine-induced activation of mTORC1. Piperine can prevent bacterial abdominal infection and further prevent septicemia, and can also enhance the functions of macrophages, including bacterial phagocytosis and TNF-alpha and IL-6 secretion capability, to prevent bacterial infection induced macrophage apoptosis. Therefore, piperine or the combination of piperine, leucine and glutamine can enhance the mTORC1 activity of bodies and be used for treating bacterial infections and septicemia.

A vaginal effervescent tablet for treating gardnerella vaginalis vaginitis and a preparing method thereof are disclosed. Raw materials for preparing traditional Chinese medicine extracts adopted as main effective components of the vaginal effervescent tablet include, by weight, 20-30 parts of limes. 15-25 parts of apricots, 8-12 parts of fresh purslane herb, 5-9 parts of golden thread, 5-9 parts of lightyellow sophora root, 4-6 parts of Japanese pagoda tree bark, 2-5 parts of golden larch bark, 3-5 parts of myrrh, 4-8 parts of honey-fried stemona root, 8-12 parts of Chinese prickly ash, 2-4 parts of pomegranate rind, 4-7 parts of great burdock achene, 3-5 parts of Japanese pagoda tree root, 3-5 parts of root of zehneria indica, 4-6 parts of common bletilla rubber, 2-4 parts of tschonosk trillium rhizome, 3-5 parts of dichocarpum auriculatum, 4-6 parts of wild chrysanthemum flower and 2-4 parts of honey-fried licorice root. The vaginal effervescent tablet is safe in formula, free of side and toxic effects, and capable of being directly applied on affected parts, inhibiting reproduction of pathogenic bacteria, promoting reproduction of lactic acid bacteria, promoting flora balance, effectively treating the disease, rapidly relieving symptoms, and preventing septicemia and other complications.

The invention discloses a preparation method of a catheter material for cerebrovascular interventional therapy, which is characterized by comprising the following steps: S1, preparation of carboxyl-terminated polyurethane / choline glycerophosphate polycondensate, S2, vinyl modification of carboxyl-terminated polyurethane / choline glycerophosphate polycondensate, and S3, crosslinking molding. The invention further discloses the catheter material for cerebrovascular interventional therapy prepared according to the preparation method. The catheter material for cerebrovascular interventional therapydisclosed by the invention is good in blood compatibility, excellent in mechanical property, non-toxic, harmless, good in surface lubricity and hydrophilicity, strong in antibacterial adhesion capacity, good in anticoagulation performance, capable of effectively preventing complications such as septicemia or phlebitis caused by interventional therapy, remarkable in cerebrovascular interventionaltherapy effect and safe to use.

The invention discloses a drug for external use for treating burn and scald, prepared from the following raw materials by weight: 35-45g of nutgall, 8-13g of euphorbiae humifusae herb, 7-12g of smilax glabra, 18-23g of antler, 27-34g of aqina root, and 3-7g of borneol. The drug is prepared by orderly placing nutgall, euphorbiae humifusae herb, smilax glabra, antler ash, borneol and aqina root, screening with a 100 mesh sieve to obtain a burn pulvis, and placing the burn pulvis in a shade place in drying and ventilation conditions for standby application; after the wound is pretreated, a proper amount of pulvis is adhered on a burned surface with 1-5mm of thickness, dosage is regulated based on the size of the burned surface, and the wound surface is opened and not bound; after 3-9days of usage of the burn pulvis, skin appears pruritus and slab, and the slab is taken down after softened with Badam oil; and the renascent skin is exposed until cure.

The invention discloses a preparation method of a traditional Chinese medicine composition for septicemia prevention. The preparation method includes steps: (1) taking Spica Prunellae, Herba Lophatheri, Rhizoma Coptidis, Radix Notoginseng and Radix Ginseng, adding 6-10 volumetric times of 80% ethyl alcohol, performing reflux extraction for 3 times and for 2-4 hours each time, combining extract liquid, and concentrating to obtain liquid extract A; (2) taking Herba Houttuyniae, Folium Isatidis, pumice and Fructus Trichosanthis, adding 8-12 volumetric times of pure water, heating, boiling, performing reflux extraction for 3 times and for 2-4 hours each time, combining extract liquid, and concentrating to obtain liquid extract B; (3) combining the liquid extract A and the liquid extract B, well mixing, and standing for 24-48h at the normal temperature; (4) filtering, and adding conventional auxiliary materials to obtain a liquid preparation or a solid preparation. Compared with the prior art, the preparation method has advantages of simple process, low cost and effectiveness in integration of raw materials; the obtained traditional Chinese medicine composition is simple in formula, precise in compatibility, accurate in dosage, effective in septicemia prevention, excellent in efficacy, low in side effect and high in patient adaptability.

The invention relates to a preparation method of low-salt Chinese yam rose preserved fish sausages. A pickling agent contains chitosan nanofibers and citric acid, wherein the chitosan nanofibers can adsorb free Cl<-> in a NaCl solution under an acidic condition to form a double electric layer, so that the concentration of free Na<+> in the solution is increased, the contact between Na<+> and a taste receptor on taste buds is increased, and as a result, the salty taste is enhanced; and chitosan has a bacteriostatic effect. Chinese yams added to the preserved fish sausages prepared with the method are diversified, have wide sources, rich active ingredients and high nutritional value and have functional effects of improving intestinal functions, improving immunity, resisting oxidation and protecting the liver and the spleen.

The invention provides an external liquid medicine, and relates to the technical field of traditional Chinese medicines. The external liquid medicine comprises the following raw materials in parts by mass: 10-20 parts of green tangerine leaves, 2-6 parts of polygonum cuspidatum, 1-2 parts of lithospermum, 1-2 parts of astragalus membranaceus and 90-180 parts of water; the external liquid medicine for treating old wounds comprises the following raw materials in parts by mass: 15-25 parts of green tangerine leaves, 3-8 parts of polygonum cuspidatum, 1.5-2.5 parts of lithospermum, 1.5-2.5 parts of astragalus membranaceus and 70-160 parts of water; and the external liquid medicine for efficient bacteriostasis and conventional infection wounds comprises the following raw materials in parts by mass: 8-18 parts of green tangerine leaves, 0.8-1.3 parts of lithospermum, 0.8-1.3 parts of astragalus membranaceus, 2.5-5 parts of polygonum cuspidatum, 0.3-0.4 part of peppermint oil and 78-159 parts of water. Through flexible combination of medicines, the external liquid medicine has a good treatment effect on new and old burns and scalds, viral wounds and dental ulcer, and is worthy of vigorous popularization.