2results about How to "Prevent sepsis" patented technology

The application belongs to the technical field of biological probes, and relates to a PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe and a preparation method thereof. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe comprises a core, a covalent organic framework and a PD-L1 antibody, the core comprises a superparamagnetic nanoparticle, the covalent organic framework is coated on the surface of the core, and the PD-L1 antibody is combined on the surface of the covalent organic framework. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe prepared by the application can be transported into the body across the membrane, smoothly enter a PD-L1 positive malignant tumor lesion, and perform Raman imaging to microscopically distinguish the tumor boundary.

This invention provides a thermoresistant Bacillus pumilus P2-7 strain and its application in the prevention and control of diseases in shrimp farming, belonging to the field of bioengineering technology. The thermoresistant Bacillus pumilus P2-7 strain provided by this invention was deposited at the Guangdong Provincial Microbial Culture Collection Center on November 4, 2024, with accession number GDMCC NO.65408. This strain differs from traditional antibacterial Bacillus strains in its antagonistic mechanism; it does not secrete metabolites with antibacterial activity, but rather exerts its effects through phage therapy. It can significantly eliminate / inhibit pathogenic bacteria in water and effectively control Shevax disease in shrimp. It also shows good efficacy in simultaneously preventing septicemia, acute hepatopancreatic necrosis, white spot syndrome, and infectious hypodermal and hematopoietic tissue necrosis in shrimp farming.