Catheter material for cerebrovascular interventional therapy and preparation method thereof

Abstract

The invention discloses a preparation method of a catheter material for cerebrovascular interventional therapy, which is characterized by comprising the following steps: S1, preparation of carboxyl-terminated polyurethane/choline glycerophosphate polycondensate, S2, vinyl modification of carboxyl-terminated polyurethane/choline glycerophosphate polycondensate, and S3, crosslinking molding. The invention further discloses the catheter material for cerebrovascular interventional therapy prepared according to the preparation method. The catheter material for cerebrovascular interventional therapydisclosed by the invention is good in blood compatibility, excellent in mechanical property, non-toxic, harmless, good in surface lubricity and hydrophilicity, strong in antibacterial adhesion capacity, good in anticoagulation performance, capable of effectively preventing complications such as septicemia or phlebitis caused by interventional therapy, remarkable in cerebrovascular interventionaltherapy effect and safe to use.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a catheter material for cerebrovascular interventional treatment and a preparation method thereof. Background technique [0002] In recent years, with the intensification of the aging population in our country, the aggravation of life and work pressure, the acceleration of the pace of life and the increasingly severe environmental problems, the incidence of diabetes has increased year by year, and the prevalence of cardiovascular and cerebrovascular and peripheral blood vessels has continued to rise. Vascular diseases represented by cerebrovascular diseases will directly endanger the lives of patients due to arterial stenosis. Therefore, individualized and targeted treatment for patients with cerebrovascular diseases is very important. [0003] At present, the treatment methods for cerebrovascular diseases mainly include drug therapy, surgical operation and interventiona...

AI Technical Summary

Problems solved by technology

However, the catheters used for cerebrovascular interventional therapy in the prior art generally have poor elasticity and flexibility, and the cost is high; blood compatibility is not ideal, and there is a risk of thrombosis in the catheter when the catheter is placed in the blood vessel for a long time; Poor lubricity, easy to cause damage to blood vessel walls and blood cells

[0005] The Chinese invention patent with the authorized notification number CN102068746B discloses a catheter combination for cerebrovascular interventional therapy, which is composed of a catheter and a contrast guide wire running through the catheter; the catheter is made of polyether polyurethane, and its surface is made of Cholesteric polymer liquid crystal and acidified modified polyether urethane are blended, cast and cross-linked. This invention solves the problems of poor elasticity and flexibility of the current catheter for cerebrovascular interventional therapy, and high cost and high price; At the same time, it also solves the problem of unsatisfactory blood compatibility and the risk of thrombosis in the catheter when the catheter is placed in the blood vessel for a long time

However, this invention does not disclose the specific composition of the cholesteric polymer liquid crystal. Liquid crystals with different structures have different effects on surface modification, and are easy to fall off. In addition, they also have toxic effects on the body.

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