Catheter material for cerebrovascular interventional therapy and preparation method thereof

An interventional therapy and cerebrovascular technology, applied in catheters and other directions, can solve problems such as undisclosed cholesteric polymer liquid crystals, poor elasticity and flexibility of catheters, damage to blood vessel walls and blood cells, etc., to improve anticoagulant function, Good surface lubricity and wettability, prevent sepsis and phlebitis

CN111282024AInactive Publication Date: 2020-06-16张鹏
1 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2020-06-16
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
Patent Text Reader

Abstract

The invention discloses a preparation method of a catheter material for cerebrovascular interventional therapy, which is characterized by comprising the following steps: S1, preparation of carboxyl-terminated polyurethane / choline glycerophosphate polycondensate, S2, vinyl modification of carboxyl-terminated polyurethane / choline glycerophosphate polycondensate, and S3, crosslinking molding. The invention further discloses the catheter material for cerebrovascular interventional therapy prepared according to the preparation method. The catheter material for cerebrovascular interventional therapydisclosed by the invention is good in blood compatibility, excellent in mechanical property, non-toxic, harmless, good in surface lubricity and hydrophilicity, strong in antibacterial adhesion capacity, good in anticoagulation performance, capable of effectively preventing complications such as septicemia or phlebitis caused by interventional therapy, remarkable in cerebrovascular interventionaltherapy effect and safe to use.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of medical devices, in particular to a catheter material for cerebrovascular interventional treatment and a preparation method thereof. Background technique

[0002] In recent years, with the intensification of the aging population in our country, the aggravation of life and work pressure, the acceleration of the pace of life and the increasingly severe environmental problems, the incidence of diabetes has increased year by year, and the prevalence of cardiovascular and cerebrovascular and peripheral blood vessels has continued to rise. Vascular diseases represented by cerebrovascular diseases will directly endanger the lives of patients due to arterial stenosis. Therefore, individualized and targeted treatment for patients with cerebrovascular diseases is very important.

[0003] At present, the treatment methods for cerebrovascular diseases mainly include drug therapy, surgical operation and interventiona...

Examples

Embodiment 1

[0029] A method for preparing a catheter material for cerebrovascular interventional therapy, comprising the steps of:

[0030]Step S1, preparation of carboxyl-terminated polyurethane / choline alphosphoric acid polycondensate: add carboxyl-terminated polyurethane, choline alfosic acid, tetrabutyl titanate, and dimethyl sulfoxide into the autoclave, replace the air in the autoclave with nitrogen, Then carry out the esterification reaction at a temperature of 230°C and an absolute pressure of 30KPa for 3 hours, end the esterification, and release the pressure to normal pressure; then, under vacuum conditions, control the temperature between 260°C, stir the reaction for 13 hours, and the reaction ends After being cooled to room temperature, the material is discharged and precipitated in water, and then the precipitated product is washed 4 times with ethanol, and the ethanol is removed by rotary evaporation to obtain carboxyl-terminated polyurethane / phosphoric acid choline polyconde...

Embodiment 2

[0035] A method for preparing a catheter material for cerebrovascular interventional therapy, comprising the steps of:

[0036] Step S1, preparation of carboxyl-terminated polyurethane / choline alphosphoric acid polycondensate: add carboxyl-terminated polyurethane, choline alfosic acid, titanium dioxide, and N,N-dimethylformamide into the autoclave, and replace the inside of the autoclave with helium Air, then carry out the esterification reaction at a temperature of 235°C and an absolute pressure of 50KPa for 3.5 hours, complete the esterification, and release the pressure to normal pressure; then under vacuum conditions, control the temperature between 265°C and stir the reaction for 14h, Cool to room temperature after completion of the reaction, discharge and precipitate in water, then wash the precipitated product 5 times with ethanol, and remove ethanol by rotary evaporation to obtain carboxyl-terminated polyurethane / phosphoric acid choline polycondensate; said carboxyl-ter...

Embodiment 3

[0041] A method for preparing a catheter material for cerebrovascular interventional therapy, comprising the steps of:

[0042] Step S1, preparation of carboxyl-terminated polyurethane / choline alphosphoric acid polycondensate: add carboxyl-terminated polyurethane, choline alfosic acid, titanium chloride, N,N-dimethylacetamide into the autoclave, and replace with neon gas The air in the kettle, and then carry out the esterification reaction at a temperature of 240°C and an absolute pressure of 60KPa for 4 hours, end the esterification, and release the pressure to normal pressure; then under vacuum conditions, control the temperature between 270°C and stir the reaction 15h, after the completion of the reaction, cool to room temperature, discharge and precipitate in water, then wash the precipitated product 6 times with ethanol, and remove ethanol by rotary evaporation to obtain carboxyl-terminated polyurethane / phosphoric acid choline polycondensate; the carboxyl-terminated The m...