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Application of cholesterol sulfate in preparation of medicine for preventing sepsis

A technology of sulfate and cholesterol, which is applied in drug combinations, pharmaceutical formulas, antibacterial drugs, etc., can solve the problems of sepsis research reports, no prevention, and blank treatment of clinical diseases, and achieve the level of reducing major inflammatory factors , improve survival rate, prevent sepsis and its complications

Active Publication Date: 2022-04-12
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, CS is only limited to being used as a drug excipient in practical applications, and the treatment of its clinical diseases is still blank, let alone its research report on the prevention of sepsis.

Method used

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  • Application of cholesterol sulfate in preparation of medicine for preventing sepsis
  • Application of cholesterol sulfate in preparation of medicine for preventing sepsis
  • Application of cholesterol sulfate in preparation of medicine for preventing sepsis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The pharmacodynamic study of embodiment 1 cholesterol sulfate

[0033] 1. Drugs

[0034] The CS used in the experiment is cholesterol sulfate, and its chemical structure is shown in formula Ⅰ:

[0035]

[0036] 2. Experimental animals:

[0037] 8-week-old C57BL / 6J male mice, weighing 18-22 g, were purchased from Beijing Huafukang Biotechnology Co., Ltd. All animals were kept in clean animal rooms. The experimental mice were divided into a sham operation control group (sham group), an operation control group, a sham operation administration group and an operation administration group. The mice in the sham operation administration group and the operation administration group were intraperitoneally injected with CS (25 mg / kg, 10% DMSO+2% Tween 20+88% saline solution) for two weeks in advance, twice a day with an interval of 12 hours; The same volume of 10% DMSO+2% Tween 20 (diluted with normal saline) was injected intraperitoneally at the same time.

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Abstract

The invention provides application of cholesterol sulfate in preparation of a medicine for preventing sepsis. Animal experiments prove that the cholesterol sulfate sodium salt can effectively prevent sepsis and complications thereof, protect the liver, the kidney, the lung and the heart, and remarkably reduce the level of TNF-alpha and IL-6 main inflammatory factors in serum of sepsis mice, so that the cholesterol sulfate sodium salt has an obvious protection effect on the body, and can be used for preventing sepsis and complications thereof. The survival rate and the survival time of sepsis mice can be remarkably improved and prolonged by injecting the cholesterol sulfate sodium salt. In general, the cholesterol sulfate provided by the invention has a good application prospect in the aspect of sepsis prevention.

Description

technical field [0001] The invention relates to the use of cholesterol sulfate in the preparation of medicines for preventing sepsis. Background technique [0002] Sepsis is a highly fatal disease concerned by intensive care medicine, and it is one of the common serious complications of patients with severe burns, trauma, major surgery, and severe infection. According to statistics, there are about 18 million cases of sepsis every year in the world, of which 30% to 45% die due to disease progression; in mainland China, patients with sepsis in the intensive care unit (ICU) account for about 18 million cases. 20%, the 90-day mortality rate is as high as 35.5%, and the annual cost of treating sepsis patients is about 4.6 billion US dollars. It not only negatively affects the patient's own health, spirit and family economy, but also increases the public health burden. [0003] Dysregulation of systemic inflammatory response in sepsis leads to multiple organ dysfunction syndrom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P31/04A61P1/16A61P13/12A61P11/00A61P9/00
Inventor 苏智广于晓倩
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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