Method for treating sepsis
A septicemia and multipurpose technology, applied in the direction of blood diseases, cardiovascular system diseases, metabolic diseases, etc., can solve the problem of lack of apoptosis inhibitors and other problems
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[0146] A, compound preparation example part
[0147] The following preparation examples exemplarily prepare part of the compounds of formula I of the present invention, each compound is represented by Co.1 to Co.32, and Co.33 represents terazosin. In the reaction schemes of the following preparation examples, "reflux" means reflux, and "1-pentanol" means 1-pentanol.
preparation example 1
[0148] Preparation Example 1: Preparation of Co.1
[0149]
[0150] Step 1: Bubble ammonia gas into a 200 mL tetrahydrofuran solution dissolved in compound 1a (50 mmol), and carry out the reaction at 25° C. for 36 hours. A large amount of white solids were precipitated in the system, and the resulting white solids were filtered and washed with tetrahydrofuran to obtain the final product 1f. Yield: 63%.
[0151]
[0152] Step 2: 15 mL of acetic anhydride was added to compound 1f (10 mmol), and the reaction was refluxed for 2 hours. After cooling to room temperature, a large amount of white solids were precipitated in the system. The resulting white solids were filtered and washed with tetrahydrofuran to obtain 1 g of the final product. Yield: 63%.
[0153]
[0154] Step 3: To a solution of 1 g (2 mmol) of 1-pentanol was added under argon atmosphere for 1 h (2 mmol). After the reaction system was refluxed for 4.5 hours, it was placed in an environment of 0-5° C. f...
preparation example 2
[0156] Preparation Example 2: Preparation of Co.2
[0157]
[0158] Step 1: Compound 1b (20 mmol) was added to compound 1a (20 mmol) in 100 mL of methanol solution, and the reaction was carried out at 25° C. for 4 hours. Thin plate chromatography indicated that 1a was completely converted, and 100 mL of diethyl ether was added to the system, mixed evenly, and placed in a -20°C environment for static crystallization. The resulting white solid was recrystallized from petroleum ether / ethyl acetate to obtain the final product 1c. Yield: 41%.
[0159]
[0160] Step 2: To a solution of 1c (2 mmol) in 1-pentanol was added 1d (2 mmol) under argon atmosphere. After the reaction system was refluxed for 4.5 hours, it was placed in an environment of 0-5° C. for static crystallization. The obtained white crystals were washed twice with 10 mL of acetone, and then recrystallized with ether / methanol to obtain the final product 1e, which was compound Co.2. Yield: 62%.
[0161] 1H ...
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