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Compositions for reducing nicotine withdrawal symptoms and/or tobacco usage

A technique for withdrawal symptoms and compositions, applied in the field of compositions for treating nicotine dependence

Inactive Publication Date: 2009-09-02
SMITHKLINE BECKMAN CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the benefits of using dextromethorphan to treat nicotine addiction can be offset by its side effects, such as drowsiness and possible abuse

Method used

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  • Compositions for reducing nicotine withdrawal symptoms and/or tobacco usage
  • Compositions for reducing nicotine withdrawal symptoms and/or tobacco usage
  • Compositions for reducing nicotine withdrawal symptoms and/or tobacco usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 & 2 Compressed Tablet Formulation

[0049] All ingredients are sieved and then mixed. The resulting mixture is then compressed using any method known in the art, such as direct compression using standard equipment well known in the art, to obtain tablets of suitable hardness for oral administration:

Embodiment 2

[0051] ingredients weight% Weight (mg / tablet) weight% Weight (mg / tablet) Cotinine 12％ 60 0.12％ 0.6 Dextromethorphan 12％ 60 0.24％ 1.2 Mannitol (filler) 64％ 320 87.64％ 438.2 Carbomer (Binder) 5％ 25 5％ 25 Magnesium Stearate (Lubricant) 2％ 10 2％ 10 Sodium starch glycolate (disintegrant) 5％ 25 5％ 25 Total 100％ 500 100％ 500

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PUM

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Abstract

Compositions useful for treating an individual with nicotine dependence comprises a combination of an alpha3belta4 nicotinic receptor antagonist and a nicotine metabolite are disclosed. More particularly, compositions comprising dextromethorphan, dextrorphan or a pharmaceutically acceptable salt thereof and further comprising cotinine or a pharmaceutically acceptable salt thereof are disclosed. Methods of alleviating nicotine withdrawal symptoms and / or tobacco usage by administration of these compositions are also disclosed.

Description

field of invention [0001] The present invention relates to a composition for the treatment of nicotine dependence comprising alpha 3 beta 4 A combination of a nicotine receptor antagonist and a nicotine metabolite. More specifically, the present invention relates to a composition comprising: dextromethorphan, dextrorphan, or a pharmaceutically acceptable salt thereof; and cotinine, or a pharmaceutically acceptable salt thereof. The invention also relates to methods of using such compositions for reducing nicotine withdrawal symptoms and reducing tobacco usage. Background of the invention [0002] It is generally known that the active and passive use of tobacco products, such as cigarettes, cigars and pipetobacco, poses serious health hazards to both smokers and those exposed to secondary smoking. It is also known that the use of smokeless forms of tobacco such as chewing tobacco, spit tobacco and snuff tobacco also poses serious health hazards to users. In addition, smok...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/44A61K31/13A61K31/16A61K31/135
CPCA61K31/485A61K31/4439A61K45/06A61P25/22A61P25/34A61P43/00A61K2300/00
Inventor 陈成裕查洛特·A·莱蒙兹
Owner SMITHKLINE BECKMAN CORP
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