A pharmaceutical composition for preventing and treating anxiety caused by alcohol

A composition and drug technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc.

Active Publication Date: 2021-03-19
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that nalmefene has the effects of treating fatty liver, reducing alcohol consumption in adult patients with alcohol dependence, and relieving symptoms of alcoholism, but there is no report on the effect of nalmefene on alcohol-induced anxiety

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: A chewable tablet for preventing and treating alcohol-induced anxiety

[0030] 10g of 7,8-dihydroxyflavone, 30g of mannitol, 30g of sorbitol, 23g of microcrystalline cellulose, 5g of sodium carboxymethylcellulose, 1g of stevioside, 0.5g of citric acid, 0.5g of lemon essence, and appropriate amount of magnesium stearate , prepared as follows:

[0031] (1) material preparation: take each raw material according to the amount, and cross 60 mesh sieves respectively for subsequent use;

[0032] (2) Mix all the 7,8-dihydroxyflavone, mannitol, sorbitol, microcrystalline cellulose, sodium carboxymethyl cellulose, stevioside, citric acid, and lemon essence, and then add an appropriate amount of water-based soft material, Granulate through a 20-mesh sieve, dry at 50°C for 1-2 hours, add magnesium stearate, mix evenly, and tablet to obtain the chewable tablet for preventing and treating alcohol-induced anxiety of the present invention.

Embodiment 2

[0033] Embodiment 2: A chewable tablet for preventing and treating alcohol-induced anxiety

[0034] Nalmefene hydrochloride 15g, mannitol 40g, sorbitol 20g, microcrystalline cellulose 18g, sodium carboxymethylcellulose 5g, glycyrrhizin 0.8g, citric acid 0.6g, apple essence 0.6g, magnesium stearate Appropriate amount, prepared according to the method of Example 1 to obtain the chewable tablet for preventing and treating alcohol-induced anxiety of the present invention.

Embodiment 3

[0035] Example 3: A chewable tablet for preventing and treating alcohol-induced anxiety

[0036] 7,8-dihydroxyflavone 9g, nalmefene hydrochloride 6g, mannitol 40g, sorbitol 20g, microcrystalline cellulose 18.7g, carboxymethylcellulose sodium 5g, aspartame 0.1g, citric acid 0.6 g, 0.6g of mango essence, appropriate amount of magnesium stearate, prepared according to the method of Example 1 to obtain the chewable tablet for preventing and treating alcohol-induced anxiety of the present invention.

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PUM

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Abstract

The invention relates to a pharmaceutical composition for preventing and treating anxiety caused by alcohol, wherein the pharmaceutical composition comprises one or two of 7,8-dihydroxy flavone, nalmefene or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, and preferably, the pharmaceutical composition for preventing and treating anxiety caused by alcohol is a chewable tablet. The pharmaceutical composition disclosed by the invention can effectively relieve anxiety caused by alcohol withdrawal reaction and reduce the probability of redrinking of a drinker, and has a remarkable relieving effect on alcohol dependence.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a pharmaceutical composition for preventing and treating anxiety caused by alcohol. Background technique [0002] my country invented wine-making technology as early as 2000 years ago, and the wine culture has a long history. Although moderate drinking can promote blood circulation and reduce the risk of cardiovascular diseases such as coronary heart disease, alcohol is one of the common addictive substances. Long-term excessive drinking will cause A state of mind that triggers the craving for alcohol, known as alcohol dependence. Alcohol dependence is one of the most common substance dependence in psychiatry at present. Not only can it lead to a variety of physical and mental diseases, but alcohol withdrawal can also produce anxiety symptoms in varying degrees, and the anxiety caused by alcohol withdrawal is the cause of alcohol withdrawal Important reason for drinking again. Therefore...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61K31/352A61K9/20A61P25/22A61P25/32
CPCA61K9/0056A61K9/2054A61K31/352A61K31/485A61P25/22A61P25/32A61K2300/00
Inventor 关艳中王娜杨印东马微刘勇王文婷李鑫鑫关子敬崔红吴宪郭冉关会林高青
Owner MUDANJIANG MEDICAL UNIV
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