Application of imatinib mesylate in preparing drugs used for building congenital cataract animal model

A technology of imatinib mesylate and congenital cataracts, which is applied in the new application field of drugs, can solve the problems of imatinib mesylate that have not yet been seen, and achieve a short cycle, low cost, and high molding rate. Effect

Inactive Publication Date: 2009-11-11
ARMY MEDICAL UNIV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are no relevant reports on the application of imatinib mesylate in the preparation of drugs for the establishment of congenital cataract models

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of imatinib mesylate in preparing drugs used for building congenital cataract animal model
  • Application of imatinib mesylate in preparing drugs used for building congenital cataract animal model
  • Application of imatinib mesylate in preparing drugs used for building congenital cataract animal model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0016] The application and effect of imatinib mesylate in the preparation of drugs for establishing animal models of congenital cataract will be described in detail below with reference to the accompanying drawings.

[0017] 1. Experimental animals and materials

[0018] Clean-grade BABL / c mice on the 8th day of birth were purchased from the Animal Center of the Third Military Medical University of the Chinese People's Liberation Army; imatinib mesylate capsules were purchased from Novartis Pharmaceuticals Co., Ltd., Switzerland. Dissolve in distilled water to make a solution with a concentration of 100 mg / mL, and store at 4°C for later use.

[0019] 2. Experimental method

[0020] The clean-grade BABL / c mice on the 8th day of birth were randomly divided into two groups: the experimental group and the control group, and the experimental group was given a concentration of Imatinib mesylate solution of 100 mg / mL was administered continuously for 3 days; the control group was g...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses an application of imatinib mesylate in preparing drugs used for building congenital cataract animal model. Applying the imatinib mesylate to build the congenital cataract animal model has the advantages of simple method, short period, low cost, high film forming rate, good reproduction quality and the like. The obtained animal model can better simulate the congenital cataract of baby lens caused by receptor signal access barrier of platelet-derived growth factors due to various reasons during the growing process before or after birth, and is applicable to studies on various aspects of the nosogenesis of the congenital cataract, therapeutic drug screening, mechanism of action, and the like.

Description

technical field [0001] The present invention relates to a new application of medicine, in particular to the application of imatinib mesylate in the preparation of medicine for establishing animal models of congenital cataract. Background technique [0002] Congenital cataract is a common eye disease in children. Partial or total clouding of the lens that occurs in the first year of life is called congenital cataract. Congenital cataract is also called infantile cataract because the factors that cause the clouding of the lens have existed at birth, but the cataract has not yet appeared, and the clouding of the lens occurs within one year old. [0003] Congenital cataract can seriously affect the development of vision, and is one of the main causes of amblyopia and blindness in children. It is more harmful than senile cataract. Its etiology is complex, in addition to heredity, fetal viral infection, malnutrition and metabolic disorders, etc., about 1 / 3 of the children have u...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61K49/00A01K67/027
Inventor 梅峰郭晟肖岚韩鹃李世峰
Owner ARMY MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap