67results about How to "High molding rate" patented technology

The invention discloses a coupling compound moulded coal binder and a preparation method thereof. The coupling compound moulded coal binder is a mixture prepared by mixing bentonite, tackifier, sodium carbonate, kaolin and sodium humate; the mixture comprises the following components in parts by weight: 350-600 parts of the bentonite, 45-55 parts of the tackifier, 3-5 parts of the sodium carbonate, 280-320 parts of the kaolin and 100-125 parts of the sodium humate; the tackifier is prepared by smashing 10-15 parts by weight of polyacrylate, 5-10 parts by weight of acrylamide, 3-5 parts by weight of cellulose, 20-25 parts by weight of cassava stalk, 3-5 parts by weight of modified starch and 0.2-0.5 part by weight of cross-linking agent into 50-100 meshes, and mxing the smashed materials. The preparation method comprises the following steps: preparing the tackifier, stocking, pretreating parts of the components, mixing, stirring and the like. The moulded coal binder has favorable waterabsorbtion performance, the moisture of an extruded and shaped coal bar is quickly evaporated and is easy to dry, thus solving the problems of high raw coal moisture, difficult moulded coal production and low shaping rate in rainy days in the south of China.

The invention discloses a modeling method of an Sjogren syndrome mouse model. The modeling method comprises the following steps: killing mice, taking out bilateral salivary glands and peeling off capsules and connective tissues; washing with PBS (Poly Butylenes Succinate); adding the PBS according to the amount of adding 0.5ml of the PBS into each salivary gland; shearing the salivary glands into pieces, and uniformly homogenizing and centrifuging in an ice bath; then taking supernatant and quantifying salivary gland antigens by adopting a BCA (Bicinchoninic Acid) protein quantifying method; adjusting the concentration of the salivary gland antigens to be 4mg/ml by utilizing the PBS; adding equal quantity of an FCA (Freund Complete Adjuvant) or an FIA (Freund Incomplete Adjuvant) and diluting the concentration to be 2mg/ml; repeatedly blowing and beating until two liquid phases are dissolved mutually to form an ivory color; randomly grouping C57BL/6 mice and shaving off furs on the backs of the mice; carrying out intradermal multi-site injection of 2mg/ml mouse salivary gland antigens prepared by the FCA on the back and tails of the mice on the current day and the 7th day, wherein the injection amount is 0.1ml per mouse; injecting equal quantity of the salivary gland antigens prepared by the FIA on the 14th day through the same method; after modeling for about 6 weeks, detecting indexes and screening the successfully modeled mice. The modeling method disclosed by the invention is high in modeling efficiency and short in modeling time.

The invention relates to a preparation method of a hepatocyte apoptosis animal disease model by coinduction of D-galactosamine and lipopolysaccharide, in particular to a simple inducer formula and a simple operation process which can generate a hepatocyte apoptosis rate above 80% and reproduce a stable and reliable hepatocyte apoptosis animal model. The invention also relates to the application of the hepatocyte apoptosis animal model to the research on the pathogenesis of hepatitis and evaluation of novel anti-hepatitis medicaments.

The invention relates to a full-automatic fruit and vegetable facial mask maker, in particular to a device for generating a facial mask by stirring and emulsifying fruit or vegetable juice and collagen. The full-automatic fruit and vegetable facial mask maker comprises a casing, a base, a facial mask forming disc, a juicing device, an emulsifying and stirring device and a driving device, wherein the driving device is arranged in the casing and used for supplying juicing driving force to the juicing device; the juicing device comprises a screw and a juicing chamber, one end of the screw is detachably connected with the driving device, the other end is nested in the juicing chamber, and the juicing chamber comprises a feeding port formed above the device, a juice outlet communicated with the emulsifying and stirring device as well as a slag hole; and the emulsifying and stirring device comprises magnetic levitation stirring and heating components, a controllable switch opening and a liquid level detector; and the facial mask forming disc can be drawn out of the facial mask maker, and a facial mask is taken out and obtained after a facial mask liquid is cooled and formed. The full-automatic fruit and vegetable facial mask maker adopts squeezing type juicing, the juice yield is high, and the juicing device and the emulsifying device adopt detachable structure, so that the devices can be cleaned.

The invention discloses a method for producing a small-dimension aluminum alloy round ingot. The problem that the yield of ingots is low caused by the fact that the surface of the aluminum alloy round ingot which is produced by a prior method has the crack defect is solved. The method comprises steps of taking and adding aluminum ingots, aluminum-manganese alloy, aluminum iron alloy, aluminum chromium alloy, zinc ingots, copper ingots and magnesium ingots to a resistance reverberatory furnace in accordance with the mass ratio of elements of the aluminum alloy round ingot, conducting complete melting and obtaining a molten body; and feeding the molten body to a stewing furnace of the resistance reverberatory furnace, feeding argon for fining, standing and preparing and obtaining the small-dimension aluminum alloy round ingot through a semi-continuous casting method. Different adding time is selected in accordance with properties of different alloy, the problem of full alloying of all elements is solved, the yield of ingots is high and reaches 90%, and the problem that the forming ratio of ingots produced by the prior method is low is solved, and the method is applied to the field of aluminum alloy production.

The invention provides a construction method of a type I diabetes animal model. The method comprises the following steps: selecting C57BL/6 mice, performing first tail vein injection, continuously performing intraperitoneal injection of a streptozotocin reagent for 5 days, performing ambrosia for 12 hours before injection, and allowing the mice to freely drink water. Two days after the injection procedure is completed, the ambrosia is carried out for 4 hours, and a glucometer is used for measuring blood glucose until the blood glucose value is 10 mmol/L or above. The statistical analysis of the blood glucose measurement result of the type I diabetes animal model shows that the C57BL/6 mouse type I diabetes model constructed by using the streptozotocin is feasible and can be used for researching the diabetes pathogenesis and the anti-hyperglycemia intervention of medicaments and health-care foods. Compared with the prior art, the C57BL/6 mouse type I diabetes model constructed by the invention has the advantages of high film forming rate, simple operation, no death of animals and good reproducibility.

The invention belongs to the technical field of biology, and particularly relates to a tumor tissue transport fluid and an application thereof. The tumor tissue transport fluid provided by the invention comprises a plurality of antibiotics and nutritional factors, is definite in components, does not contain serum, can significantly improve the defect of nutrient depletion of previous tissue transport fluids, and avoids activity reduction of tumor samples in storage or transportation to a great extent. The transport liquid provided by the invention is simple to prepare, can effectively improvethe activity of a fresh tumor sample, can well protect the cellular morphology of the tumor sample, can significantly increase the modeling rate of PDX, shortens the modeling time, has great help forestablishment of a PDX tumor model and has a high commercial application value.

The invention relates to a method for constructing a gastroparesis rat model, relating to a method for constructing an animal model for medical research. The method is characterized in that 6-OHDA (Hydroxydopamine) is used for destroying nerve nuclei in a position with coordinates of AP=-5mm, ML=+/-2mm, and DV=-8mm, the dysinsulinism function and the glycometabolism function of an animal are not disturbed, and the method for constructing a non-diabetic gastroparesis rat model which has high modeling rate, low death rate, simpleness in operation, stable results and easiness in standardization is provided, therefore a new tool is provided for systematic research on the nosogenesis of gastroparesis, especially the research on non-diabetic gastroparesis.

The invention discloses a method for constructing a bronchial asthma model of a primate. The method comprises the following steps by taking house dust mites as allergens, carrying out first week intraperitoneal injection administration, second week intraperitoneal injection administration, fourth week subcutaneous injection administration, fifth week atomization administration, seventh week intramuscular injection administration, eighth week atomization administration, twelfth week intramuscular injection administration, fifteenth week atomization administration on primates to cause sensitization, and constructing a primate model of bronchial asthma According to the method, the bronchus asthma model of the cynomolgus monkey conforms to the clinical characteristics of asthma in the aspectsof inflammatory cells, serum inflammatory cytokines, airway obstruction characteristics and morbidity symptoms, and the hypersensitivity of a sensitization original skin test is positive, which indicates that house dust mites are sensitized in monkey bodies after modeling.

The invention discloses a special system for preparing pellets for calcium carbide semi-coke forming. The system comprises a quick lime crushing device, a solid asphalt crushing device, a quick pyrolytic device, a first mixing device, a second mixing device and a pelletizing device. The invention also discloses a method for preparing pellets for calcium carbide semi-coke forming by the special system. The method includes crushing quick lime and solid asphalt respectively in the crushing devices; mixing the crushed quick lime and solid asphalt in the first mixing device to obtain a mixture; evenly mixing semi-coke powder from the quick pyrolytic device with the mixture entering the second mixing device to obtain a mixed material; pelletizing the mixed material in the pelletizing device. The special system and the method have the advantages that the problems of difficulty in forming binder selection, complicated forming technologies, high forming cost and requirements on subsequent drying during calcium carbide semi-coke forming are solved, and the special system and the method are high in technological forming rate, stable in forming operation, high in formed pellet strength and low in forming cost.

The invention belongs to the technical field of medical science, and particularly relates to an establishment method of a bone marrow suppression mouse model. The problems that at present, a bone marrow suppression animal model is low in modeling rate and poor in repeatability are solved. The method comprises the steps that an NOD or SCID mouse is adopted, the abdominal cavity of the mouse is injected with 150 mg/kg, calculated according to the initial body weight, of cyclophosphamide, injection is conducted every other day, injection is conducted three times in total, the observation period is 15 days, and the bone marrow suppression mouse model can be obtained. According to the method for establishing the bone marrow suppression mouse model, operation is easy, the modeling rate is high, the repeatability is good, the method can be used for various experimental animals, a foundation is laid for research on bone marrow suppression experiments, the bone marrow suppression experiments and clinical application research can be more normalized and standardized, objective and accurate verification on drug efficacy and action mechanisms of various drugs for preventing and treating bone marrow suppression is facilitated, further guidance on selection and evaluation of clinical treatment schemes is facilitated, and guidance on pharmacology experiments and development of new drugs for treating bone marrow suppression is facilitated.

The invention discloses a diabetes-coronary heart disease combined animal model building method based on a ZDF rat; the method comprises the following steps: adaptively feeding the ZDF male rat with diabetes for 2 weeks; injecting isoprenaline hydrochloride solution everyday in a hypodermic manner for 10 days, wherein the injection capacity is 1mg.kg-1; detecting serum creatine jubase (CK) and creatine jubase isozyme (CK-MB) activity, observing tissue form changes, and evaluating the model. The method uses the ZDF rat, and combines continuous administration with high fat feeding so as to form the diabetes-coronary heart disease combined animal model; the method is short in period, and high in modeling rate.

The invention provides a method for building a mouse renal anemia animal model. The method comprises the following steps: 1) preparing a 0.4 mg/mL aristolochic acid solution from aristolochic acid with PBS (Phosphate Buffer Saline); 2) injecting the aristolochic acid solution into the enterocoelia of a mouse for 6 weeks, 3 mg/kg once every 3 days, and detecting anemia, renal function index, renalpathology and capability of secretion of hemopoietin; 3) stopping administration for 6 weeks, and observing the previous indexes again. The mouse renal anemia animal model built by the method is stable and has high modeling rate, and the problem that renal anemia has a higher incidence rate among chronic kidney diseases but a mature renal anemia animal model is lacked at present is solved.

The invention discloses a polymethyl methacrylate mold for manufacturing a complex-section tunnel lining model. The polymethyl methacrylate mold comprises a polymethyl methacrylate base, a polymethylmethacrylate outer mold and one or a plurality of polymethyl methacrylate inner molds. The polymethyl methacrylate outer mold is a closed type cylindrical body composed of a plurality of curved wall type columnar outer mold plates with outside handles, and a joint seam is reserved between every two adjacent outer mold plates. Each polymethyl methacrylate inner mold is a closed type cylindrical body composed of a plurality of curved wall type columnar inner mold plates with inside handles, and a joint seam is reserved between every two adjacent inner mold plates. Clips are arranged at the top joint seams of the polymethyl methacrylate outer mold and the polymethyl methacrylate inner molds. The polymethyl methacrylate base is provided with an outer mold slot and one or a plurality of inner mold slots. The bottom of the polymethyl methacrylate outer mold is completely inserted into the outer mold slot, and the bottoms of the polymethyl methacrylate inner molds are all inserted into the inner mold slots. The polymethyl methacrylate inner molds are located on the inner side of the polymethyl methacrylate outer mold, and a tunnel lining model pouring groove is reserved between the polymethyl methacrylate inner molds and the polymethyl methacrylate outer mold.

The invention discloses a machining device and method for a magnesium alloy sacrificial anode bar, and relates to the technical field of machining of magnesium alloy sacrificial anode bars. The machining device comprises a first motor, a three-jaw chuck, a nut and a magnesium alloy sacrificial anode bar body, wherein the three-jaw chuck is arranged at the output end of the first motor. According to the machining device and method for the magnesium alloy sacrificial anode bar, through the design of an auxiliary friction welding device, the device can conveniently complete multi-angle reciprocating hammering in the friction welding machining process of the magnesium alloy sacrificial anode bar, so that the friction welding machining effect and forming stability of the magnesium alloy sacrificial anode bar are further improved; and through the design of an automatic clamping anti-shaking and anti-falling feeding device, the device can conveniently complete automatic positioning of anti-shaking and anti-falling of the magnesium alloy sacrificial anode bar in the machining process of the magnesium alloy sacrificial anode bar, so that machining of the magnesium alloy sacrificial anode bar is facilitated, and the machining forming rate is increased.

The invention discloses a rapid modeling method for childhood rat type 1 diabetes mellitus. The method comprises the following steps: performing intravenous injection of streptozotocin for a childhoodrat after abrosia and water deprivation, with injection amount of 50-60mg.kg-1 once, and the frequency of one time each day, which lasts for 4 days continuously; and inducing to establish a model. The invention provides an effective and rapid method for modeling of the childhood rat type 1 diabetes mellitus. According to the method disclosed by the invention, tail intravenous injection is adopted, and in combination with specific STZ dosage, the method is strong in operability and convenient and practical, and a childhood rat T1DM model with typical clinical symptoms can be successfully and rapidly established.

The invention a method for constructing an azoospermia mouse model, comprising the following steps: (1) providing sexually mature male mice weighing 25-35g; (2) dissolving busulfan in DMSO and diluting with normal saline to obtain a diluent; and (3) sterilizing the mouse abdomen with alcohol and drying, absorbing the diluent obtained in step (2) and inserting the needle, and completing the first intraperitoneal injection after withdrawal and confirmation; repeating the injection for three times at intervals in the same day and then obtaining the azoospermia mouse model after 35 to 37 days. Themethod provided by the invention has high success rate of modeling and good stability. According to the invention, modeling of 84 C57BL/6 mice with azoospermia has been cumulatively completed. Totalnumber of models is 84/84 by testicular HE staining identification, and the success rate of modeling is 100%. By the adoption of the method for constructing the model, the death rate of mice is 0%; and according to the method, among 84 cumulatively-injected C57BL/6 mice, the death toll is 0, and the death rate is 0%.

The invention provides a headgear for preparing an eye disease model, application of the headgear and a preparation method of the eye disease model, and belongs to the technical field of animal model construction. The head tool for preparing the eye disease model comprises a mounting piece, an eye socket frame and an eye disease simulation lens. The mounting piece comprises a fixing part and a mounting part which are connected with each other, and the fixing part is used for fixing an animal skull; the orbit frame is provided with a connecting part and an object viewing through hole, the connecting part is connected with the mounting part, and the object viewing through hole is used for animals to view objects; the eye disease simulation lens is detachably arranged in the visual through hole. The preparation method of the eye disease model is carried out by adopting the headgear for preparing the eye disease model, different types of ametropia can be prepared, the preparation of different types of eye disease models can be reliably realized, and the construction of an animal model is ensured to have relatively good stability consistency and model forming rate.