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Device for removing leukocytes from blood

A technology for leukocytes and equipment, applied in the field of equipment for removing leukocytes, can solve problems such as filter blockage and difficult operation

Inactive Publication Date: 2009-12-23
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If blood clotting occurs despite the presence of an anticoagulant, it can cause filter clogging
[0010] Another disadvantage of conventional leukocyte filters is the often difficult handling prior to clinical use, e.g. related to exhaust

Method used

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  • Device for removing leukocytes from blood
  • Device for removing leukocytes from blood
  • Device for removing leukocytes from blood

Examples

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Embodiment Construction

[0052] Figure 1a A preferred embodiment of the device according to the invention with inlet means and outlet means on the housing shell is shown. In this embodiment, the inlet device 1 is arranged at one end of the housing shell 2 and the outlet device 3 is mounted offset by 180° at the other end of the housing shell. For example a luer lock type connector as shown can be used for the inlet or outlet device, however all other connectors known to a person skilled in the art can also be used. The ends of the hollow fibers 4 are embedded in a plug 5 which is connected to the inside of the housing, so that the ends of the hollow fibers 4 lie in the plug 5 and are closed by the plug 5 . The inner cavity of the embedded hollow fiber 4 is not accessible, while only the outer surface of the hollow fiber is accessible. In the preferred embodiment shown, the hollow fibers 4 are embedded with their ends separated in plug packings 5 ​​and extend essentially parallel between these plug p...

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Abstract

The invention relates to a device for removing leukocytes from blood, comprising a number of hollow fibres made from organic polymers, wherein the hollow fibres have a lumen and a wall enclosing the lumen with an inner lumen-side surface and an outer surface, the hollow fibres are arranged in a cylindrical housing with an inlet device and an outlet device and an external volume is formed between the hollow fibres and the housing, accessible to a fluid by means of the inlet device and the outlet device, characterised in that only the outer surfaces of the hollow fibres are accessible to a fluid, the lumina of the hollow fibres are accessible to a fluid, the arrangement of the hollow fibres has a high degree of organisation and the hollow fibres form the complement activation product C5a with a concentration of at least 10 [mu]g per m of fibre surface from organic polymers.

Description

technical field [0001] The invention relates to a device for removing white blood cells from blood. Background technique [0002] Blood basically consists of plasma and cellular components. These cellular components include red blood cells (red blood cells), blood clotting cells (platelets), and white blood cells (leukocytes). White blood cells include lymphocytes, monocytes and neutrophils (neutrophils, PMN). Lymphocytes play a decisive role in specific immunity; monocytes and neutrophils are cell types involved in nonspecific immune system defense or inflammatory responses. Their task is, for example, to destroy invading microorganisms which have previously been appropriately recognized as foreign by certain endogenous proteins, ie by C3b of the complement system or by immunoglobulin IgG. [0003] If the cell approaches an invading microorganism, the cell releases oxygen and proteases by which the microorganism is killed in order to then phagocytose it. If the reaction...

Claims

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Application Information

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IPC IPC(8): A61M1/36
CPCA61M1/3633A61M1/34
Inventor F·霍伊泽尔M·柯尼希H-D·莱姆克B·冯哈尔滕
Owner 3M INNOVATIVE PROPERTIES CO
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