Thermal sensitive liposome preparation containing camptothecin antineoplastic agents

A technology of liposome preparations and anti-tumor drugs, which is applied in the direction of anti-tumor drugs, liposome delivery, medical preparations containing active ingredients, etc., and can solve the problem of short residence time of drugs

Inactive Publication Date: 2013-02-13
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although ordinary liposomes can improve the curative effect of anticancer drugs, they are easily absorbed by macrophages in the liver and spleen and eliminated quickly, and the drug stays in the body for a short time.

Method used

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  • Thermal sensitive liposome preparation containing camptothecin antineoplastic agents
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  • Thermal sensitive liposome preparation containing camptothecin antineoplastic agents

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Embodiment Construction

[0021] The invention is further described below. All the documents cited in the present invention are incorporated herein by reference in their entirety, and if the meaning expressed in these documents is inconsistent with the present invention, the expression of the present invention shall prevail. In addition, various terms and phrases used in the present invention have common meanings known to those skilled in the art. Even so, the present invention still hopes to make a more detailed description and explanation of these terms and phrases here. The terms and phrases mentioned are as follows: If there is any inconsistency with the known meaning, the meaning expressed in the present invention shall prevail.

[0022] The present invention proposes a thermosensitive liposome delivery system for injection of camptothecin drugs, which is characterized in that the liposomes contain camptothecin anti-tumor drugs and have a phase transition above a suitable temperature. And can rel...

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Abstract

The invention relates to a thermal sensitive liposome preparation containing camptothecin antineoplastic agents, which contains the camptothecin antineoplastic agents, common lipoid, a phase-change regulator and an optional long-circulating material, wherein the phase-change regulator accounts for 6-100% of the weight of liposome, the long-circulating material accounts for 0-40% of the weight of the liposome, and the weight ratio of the amptothecin antineoplastic agents to the liposome is 1:0.5-1:100. Since the liposome preparation is characterized by thermal sensitivity, when the tissues of a tumor are heated partially, the liposome is targeted to the position of the tumor and releases a lot of medicine at the position of the tumor, thereby improving the curative effect and reducing the overall toxic and side effect. The camptothecin antineoplastic agents of the inveition can include water-solubility derivatives, such as irinotecan and topotecan, and water-insolubility derivatives, such as hydroxycamptothecine, SN-38, 9-NC, and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a thermosensitive liposome drug delivery system loaded with anticancer drugs, specifically to a thermosensitive liposome preparation containing camptothecin antitumor drugs. Background technique [0002] Whether abroad or at home, tumors are still one of the major diseases that are common and seriously threaten people's lives and quality of life. It is based on this understanding that governments, research institutions and pharmaceutical companies have long attached great importance to and invested heavily in tumor research and anti-tumor drug development, resulting in continuous progress in cancer treatment. Drug therapy plays an active and irreplaceable role in tumor treatment or comprehensive treatment, prolonging the life of tumor patients and improving their quality of life. Antineoplastic drugs are currently widely used clinically, but their side effect...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K45/00A61K31/4745A61K47/24A61K47/34A61K47/36A61P35/00A61K47/10A61K47/14
Inventor 梅兴国
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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