Traditional Chinese medicine composition for treating hyperglycemia and preparation method thereof

Abstract

The invention relates to a traditional Chinese medicine composition for treating hyperglycemia and a preparation method thereof. The composition consists of 4 to 10 percent by weight of coptis root extract, 4 percent to 11 percent by weight of lamiophlomis rotate extract, 5 percent to 8 percent by weight of achyranthes bidentata extract, 5 percent to 11 percent by weight of Philippine violet herb, 5 percent to 9 percent by weight of round cardamom extract, 8 percent to 11 percent by weight of pomegranate extract, 4 percent to 9 percent by weight of bletilla extract, 2 percent to 11 percent by weight of cascara extract, 8 percent to 12 percent by weight of long pepper extract, 2 percent to 11 percent by weight of eucommia bark extract and one or more pharmaceutically acceptable additives.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine composition for treating hyperglycemia and a preparation method thereof. Background technique

[0002] Hyperglycemia is a disorder in which blood sugar is measured, either because the body cannot produce enough insulin or because the body's cells do not respond properly to produce insulin. Insulin is a hormone produced by the pancreas that helps the body's cells absorb sugar and break it down for energy. If the body's cells cannot absorb the sugar, it will accumulate in the blood, causing high blood sugar and leading to various potential complications.

[0003] As of 2000, there are at least 1.71 million people suffering from hyperglycemia worldwide, or 2.8% of the population suffering from hyperglycemia. Type 1 therapy usually includes a combination of regular or potent insulins, and / or synthetic insulin analogs. However, there are various defects in the various medicines that have at present,...

Examples

Embodiment 1

[0017] The dosage of streptozotocin is used to induce hyperglycemia similar to NIDDM, and most of clinical patients have hyperglycemia in MDDM. When NIDDM hyperglycemia rats were treated with the traditional Chinese medicine composition of the present invention for 2-3 weeks, the rats returned to normal state, while the hyperglycemia symptoms of the rats in the NIDDM control group still existed and died after a period of time.

Embodiment 2

[0019] Get 8% by weight of Coptidis Rhizoma extract and 7% by weight of Duyiwei extract, 5% by weight of Achyranthes knuckles extract, 8% by weight of Rhizome extract, 6% by weight of Cardamom extract, 9% by weight of pomegranate extract, 5% by weight of white root extract, 3% by weight of cascara extract, 8% by weight of longan extract, and 5% by weight of Eucommia extract with a One or more pharmaceutically acceptable additives are used to prepare the traditional Chinese medicine composition of the present invention.

[0020] Utilize normal, fasting 18h, sugar load (glucose loaded) and streptozotocin-induced hyperglycemia rats detect as can be seen, the Chinese medicine composition of the present invention (200mg / kg oral administration) has the activity of obviously reducing blood sugar . The onset of effect is within 1 / 2 hour, and the effect lasts for more than 5 hours. In rats fasted for 18 hours, the blood glucose drop of the above dose was recorded as 26 mg / dl (n=24), ...

Embodiment 3

[0022] Take 4% by weight of Coptis chinensis extract and 9% by weight of Duyiwei extract, 8% by weight of Achyranthes bidentata extract, 10% by weight of chrysanthemum fruit extract, 5% by weight of cardamom extract, 10% by weight of pomegranate extract, 9% by weight of white root extract, 10% by weight of cascara extract, 8% by weight of longan extract, and 10% by weight of Eucommia extract with a One or more pharmaceutically acceptable additives are used to prepare the traditional Chinese medicine composition of the present invention.

[0023] Oral administration of the composition (200 mg / kg / day) for 2 to 3 weeks has significant curative effect on non-insulin-dependent hyperglycemia, and the curative effect is measured by the following indicators: i) blood sugar level, ii) impact on body weight, iii) Animal survival, iv) water intake, urinary excretion & presence of glucose in urine, v) general symptoms of animals, and vi) ant patronage of rat excreted urine.

technical field

[0001] The invention relates to a traditional Chinese medicine composition for treating hyperglycemia and a preparation method thereof. Background technique

[0002] Hyperglycemia is a disorder in which blood sugar is measured, either because the body cannot produce enough insulin or because the body's cells do not respond properly to produce insulin. Insulin is a hormone produced by the pancreas that helps the body's cells absorb sugar and break it down for energy. If the body's cells cannot absorb the sugar, it will accumulate in the blood, causing high blood sugar and leading to various potential complications.

[0003] As of 2000, there are at least 1.71 million people suffering from hyperglycemia worldwide, or 2.8% of the population suffering from hyperglycemia. Type 1 therapy usually includes a combination of regular or potent insulins, and / or synthetic insulin analogs. However, there are various defects in the various medicines that have at present,...

Examples

Embodiment 1

[0017] The dosage of streptozotocin is used to induce hyperglycemia similar to NIDDM, and most of clinical patients have hyperglycemia in MDDM. When NIDDM hyperglycemia rats were treated with the traditional Chinese medicine composition of the present invention for 2-3 weeks, the rats returned to normal state, while the hyperglycemia symptoms of the rats in the NIDDM control group still existed and died after a period of time.

Embodiment 2

[0019] Get 8% by weight of Coptidis Rhizoma extract and 7% by weight of Duyiwei extract, 5% by weight of Achyranthes knuckles extract, 8% by weight of Rhizome extract, 6% by weight of Cardamom extract, 9% by weight of pomegranate extract, 5% by weight of white root extract, 3% by weight of cascara extract, 8% by weight of longan extract, and 5% by weight of Eucommia extract with a One or more pharmaceutically acceptable additives are used to prepare the traditional Chinese medicine composition of the present invention.

[0020] Utilize normal, fasting 18h, sugar load (glucose loaded) and streptozotocin-induced hyperglycemia rats detect as can be seen, the Chinese medicine composition of the present invention (200mg / kg oral administration) has the activity of obviously reducing blood sugar . The onset of effect is within 1 / 2 hour, and the effect lasts for more than 5 hours. In rats fasted for 18 hours, the blood glucose drop of the above dose was recorded as 26 mg / dl (n=24), ...

Embodiment 3

[0022] Take 4% by weight of Coptis chinensis extract and 9% by weight of Duyiwei extract, 8% by weight of Achyranthes bidentata extract, 10% by weight of chrysanthemum fruit extract, 5% by weight of cardamom extract, 10% by weight of pomegranate extract, 9% by weight of white root extract, 10% by weight of cascara extract, 8% by weight of longan extract, and 10% by weight of Eucommia extract with a One or more pharmaceutically acceptable additives are used to prepare the traditional Chinese medicine composition of the present invention.

[0023] Oral administration of the composition (200 mg / kg / day) for 2 to 3 weeks has significant curative effect on non-insulin-dependent hyperglycemia, and the curative effect is measured by the following indicators: i) blood sugar level, ii) impact on body weight, iii) Animal survival, iv) water intake, urinary excretion & presence of glucose in urine, v) general symptoms of animals, and vi) ant patronage of rat excreted urine.