Antimicrobial and antidandruff composition and application thereof

Abstract

The invention discloses an antimicrobial and antidandruff composition and application thereof. The composition comprises a pyrithione polyvalent metal salt and an alkoxy aromatic amidine compound, and preferably comprises zinc pyridine thione and hexamidine isethionate, wherein the weight ratio of the zinc pyridine thione to the hexamidine isethionate in the composition is 1:20-10000:1. The composition can be applied in washing-off systems such as liquid shampoos, hair conditioners, facial cleansers, dermatophytosis removal products or shower gel and the like which have the effects of sterilization and antibiosis. The antimicrobial and antidandruff composition can provide the high-efficiency effect of dandruff removal and sterilization, overcome the defect that the effects of dandruff removal, sterilization and itching relieving are not obvious due to the single use of any one component in the composition under the same condition, and play an excellent role in the dandruff removal, sterilization and itching relieving; and the zinc pyridine thione and the hexamidine isethionate have the synergic effect on the using effect, and the composition is used in products under the same using condition and using amount to reduce the amount used when only single component in the composition is used effectively, so the effects of the dandruff removal and itching relieving can be achieved.

Description

technical field

[0001] The invention belongs to the field of daily chemical products, and relates to an antibacterial and dandruff-removing composition and its application, in particular to a composition comprising pyrithione polyvalent metal salt and an alkoxy aromatic amidine compound and its application. Background technique

[0002] In daily life, most adults experience the confusion of dandruff and itchy head. Usually, there are two reasons for human dandruff and itching: one is the metabolism of epidermal cells, and the keratinization of cells produces dandruff; the other is seborrheic fungal infection adsorbed on the skin, especially oval bran spore fungus. In the patent CN200710135779.8, it is mentioned that Pityrosporum ovale enters the scalp, and the abnormal flora activity leads to the enhancement of its reproductive ability, and its anaerobic metabolism accelerates the metabolism of scalp epidermal cells, and lipase decomposes triglycerides into free The fatty ...

Examples

Embodiment 1

[0036] Minimum Inhibitory Concentration Test

[0037]The in vitro bacteriological experiment is to judge the activity of the antibacterial agent by the minimum inhibitory concentration (MIC) to several bacterial species. In the experiment, several representative scalp common fungi and bacteria shown in Table 1 were selected for antibacterial test, and the growth of the control bacteria on the basal medium without any test samples was used as a reference, and the single compound or the mixture The minimum sample concentration used to inhibit the growth of bacteria on the medium is the minimum inhibitory concentration (MIC). Compare the results of using ZPT and hexamidine isethionate (HD) alone and mixing ZPT and HD in different proportions. Bacteriostatic effect. The mixing ratio of ZPT to HD varies from 1:8 to 1000:1.

[0038] The fungus culture medium that the present invention adopts is as follows:

[0039] 1. Evaluation of Candida albicans and Aspergillus niger using mod...

Embodiment 2

[0058] Embodiment 2 shampoo preparation embodiment

[0059] In this embodiment, example 1 is compared with example 2, example 3 is compared with example 4, example 5 is compared with example 6, and example 7 is compared with example 8.

[0060] Add polymers such as polyquaternium-10 or guar gum in water to wet it first, stir evenly, heat to 75°C, add surfactants of different properties such as sodium lauroamphoacetate, betaine to the system in turn , Fatty Alcohol Ether Ammonium Sulfate, Fatty Alcohol Ethoxylate Sodium Sulfate, Sodium Lauryl Sulfate, Ammonium Lauryl Sulfate, Coco Monoethanolamide or Coco Diethanolamide, Tallow Phthalamide , pearlescent paste or pearlescent diester, you can also add a small amount of zinc salt such as zinc oxide or zinc chloride and stir until the system is completely dissolved, stop heating, add a pre-dispersed acrylic polymer such as acrylic resin copolymer or carbo, the system Adjust the pH with citric acid or triethanolamine, add zinc pyri...

preparation example

[0062]

[0063]

technical field

[0001] The invention belongs to the field of daily chemical products, and relates to an antibacterial and dandruff-removing composition and its application, in particular to a composition comprising pyrithione polyvalent metal salt and an alkoxy aromatic amidine compound and its application. Background technique

[0002] In daily life, most adults experience the confusion of dandruff and itchy head. Usually, there are two reasons for human dandruff and itching: one is the metabolism of epidermal cells, and the keratinization of cells produces dandruff; the other is seborrheic fungal infection adsorbed on the skin, especially oval bran spore fungus. In the patent CN200710135779.8, it is mentioned that Pityrosporum ovale enters the scalp, and the abnormal flora activity leads to the enhancement of its reproductive ability, and its anaerobic metabolism accelerates the metabolism of scalp epidermal cells, and lipase decomposes triglycerides into free The fatty ...

Examples

Embodiment 1

[0036] Minimum Inhibitory Concentration Test

[0037]The in vitro bacteriological experiment is to judge the activity of the antibacterial agent by the minimum inhibitory concentration (MIC) to several bacterial species. In the experiment, several representative scalp common fungi and bacteria shown in Table 1 were selected for antibacterial test, and the growth of the control bacteria on the basal medium without any test samples was used as a reference, and the single compound or the mixture The minimum sample concentration used to inhibit the growth of bacteria on the medium is the minimum inhibitory concentration (MIC). Compare the results of using ZPT and hexamidine isethionate (HD) alone and mixing ZPT and HD in different proportions. Bacteriostatic effect. The mixing ratio of ZPT to HD varies from 1:8 to 1000:1.

[0038] The fungus culture medium that the present invention adopts is as follows:

[0039] 1. Evaluation of Candida albicans and Aspergillus niger using mod...

Embodiment 2

[0058] Embodiment 2 shampoo preparation embodiment

[0059] In this embodiment, example 1 is compared with example 2, example 3 is compared with example 4, example 5 is compared with example 6, and example 7 is compared with example 8.

[0060] Add polymers such as polyquaternium-10 or guar gum in water to wet it first, stir evenly, heat to 75°C, add surfactants of different properties such as sodium lauroamphoacetate, betaine to the system in turn , Fatty Alcohol Ether Ammonium Sulfate, Fatty Alcohol Ethoxylate Sodium Sulfate, Sodium Lauryl Sulfate, Ammonium Lauryl Sulfate, Coco Monoethanolamide or Coco Diethanolamide, Tallow Phthalamide , pearlescent paste or pearlescent diester, you can also add a small amount of zinc salt such as zinc oxide or zinc chloride and stir until the system is completely dissolved, stop heating, add a pre-dispersed acrylic polymer such as acrylic resin copolymer or carbo, the system Adjust the pH with citric acid or triethanolamine, add zinc pyri...

preparation example

[0062]

[0063]

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