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Picoplatin and amrubicin to treat lung cancer

A technology of amrubicin and picoplatin, applied in the field of picoplatin and amrubicin in the treatment of lung cancer, can solve the problems of no survival benefit, no response rate, and unmet needs for improved chemotherapy of lung cancer

Inactive Publication Date: 2011-04-13
PONIARD PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these drugs have neither significant response rates nor survival benefits, and use in these populations is often accompanied by drug-related toxicities
This is highly consistent with the published literature: currently there are no treatments that provide significant benefit to refractory or resistant patients
[0009] Thus, there is clearly an unmet need for improved chemotherapy for lung cancer

Method used

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  • Picoplatin and amrubicin to treat lung cancer
  • Picoplatin and amrubicin to treat lung cancer
  • Picoplatin and amrubicin to treat lung cancer

Examples

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Embodiment Construction

[0021] References in the specification to "one embodiment" or "an embodiment" mean that the embodiments may include a particular feature, structure or characteristic, but not every embodiment may include the particular feature, structure or characteristic. Moreover, these phrases are not necessarily referring to the same embodiment. Further, when a particular feature, structure or characteristic is described in conjunction with an embodiment, it should be considered to be within the knowledge of those skilled in the art to implement the feature, structure or characteristic in combination with other embodiments whether explicitly described or not. According to the present invention, the term "embodiments" refers to one or more, but not necessarily all, embodiments.

[0022] Unless otherwise specified, words and phrases mentioned in this application have their ordinary meanings as understood by those skilled in the art. Such ordinary meanings can be obtained by reference to its...

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Abstract

A method for treatment of lung cancer comprising administration of picoplatin and amrubicin, or comprising radiation therapy and picoplatin is provided. A use of picoplatin in conjunction with amrubicin for treatment of lung cancer is provided. The lung cancer can be SCLC or NSCLC. The cancer can be resistant or refractory to treatment or that progresses following cessation of first-line organoplatinum chemotherapy. The treatment can include the administration of picoplatin and amrubicin, optionally in conjunction with a regimen of best supportive care. Multiple doses of the drug or drug combination can be administered.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Ser. No. 61 / 027,387 filed Feb. 8, 2008, U.S. No. 61 / 027,382 filed Feb. 8, 2008, U.S. No. 61 / 027,360 filed Feb. 8, 2008 , the disclosure of which is incorporated herein by reference. This application also claims U.S. Ser. Nos. 60 / 857,066 filed Nov. 6, 2006, U.S. Ser. Nos. 60 / 857,725 filed Nov. 8, 2006, U.S. Ser. U.S. No. 60 / 889,191 filed February 9, 2007, U.S. No. 60 / 931,589 filed March 24, 2007, U.S. No. 60 / 983,852 filed October 30, 2007, November 5, 2007 Priority to filed US Ser. No. 11 / 982,841, the disclosure of which is incorporated herein by reference. Background technique [0003] Small cell lung cancer (SCLC) accounts for approximately 14% of all lung cancers. In 2004, there were about 26,000 new cases in the United States and about 51,000 new cases in Europe (Jemal, 2004). The median survival time of untreated SCLC patients is two to four months (Clark, 1998; Glisson, 2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/04A61K31/70
CPCA61K31/44A61K39/3955A61K31/519A61K31/513A61P35/00A61P35/04A61P43/00A61K2300/00
Inventor 罗纳德·A·马特尔大卫·A·卡林
Owner PONIARD PHARMA INC
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