64 results about "Platinum-containing Compounds" patented technology

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inhibitors, NSAIDs, taxanes and platinum containing compounds use broader language

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of LAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inbhibitors, NSAIDs, taxanes and platinum containing compounds use broader language

The invention relates to a preparation method of a catalyst for catalytic combustion of VOCs (volatile organic compounds). The preparation method comprises the following steps of: dissolving a vanadium-containing compound and a lanthanide-series compound in an oxalic acid solution and stirring till the compounds are complete dissolved; dissolving TiO2 powder in the solution, stirring at normal temperature, filtering, washing, drying, grinding to obtain powder, and calcining the powder for 3 hours at the temperature of 500 DEG C, thus obtaining MOx / V2O5-TiO2 powder; mixing and stirring the MOx / V2O5-TiO2 powder and a platinum-containing compound solution, drying sediment, and calcining the sediment for 5 hours at the temperature of 400 DEG C, thus obtaining the catalyst Pt / MOx / V2O5-TiO2. The catalyst prepared by the method provides a large specific surface area and has a very high catalytic activity to the catalytic combustion reaction of benzene series materials such as benzene; in addition, raw materials for preparation are easy to obtain and the technology is simple; the catalyst can be used repeatedly with stable activity, and the defects that the traditional noble metal catalyst is sintered easily and causes intoxication easily are overcome. The catalyst can also be used for eliminating other volatile organic compounds such as halogenated hydrocarbon, ketone and ester from industrial waste gas in a catalytic combustion manner.

Platinum compounds, pharmaceutically acceptable salts, and prodrugs thereof. Compositions that include the platinum compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier. Methods for using the platinum compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.

The invention relates to a preparing method of cube platinum ruthenium core-shell nanocrystalline. The preparing method comprises the following steps that firstly, ruthenium(III)2,4-pentanedionate, a platinum-containing compound and trioctylphosphine oxide are dissolved in a mixed solution of oleylamine and N,N-dimethylformamide, wherein the platinum-containing compound is chloroplatinic acid or sodium chloroplatinate; secondly, the mixed solution obtained in the first step is stirred to be subjected to the reaction for 30-600 min at the temperature of 180-250 DEG C; and thirdly, a product obtained in the second step is separated, and then sediment, namely the cube platinum ruthenium core-shell nanocrystalline is obtained. The invention further relates to the cube platinum ruthenium core-shell nanocrystalline prepared through the method. According to the preparing method, the cube platinum ruthenium core-shell nanocrystalline uniform in appearance and size is obtained through a one-step method, the obtained product is moderate in size and good in dispersibility, and the preparing method is simple.

The invention relates to the technical fields of a chemical catalyst and preparation thereof, particularly to a method for preparing a spherical shell type catalyst for catalytic combustion of VOCs (volatile organic compounds). The method comprises the steps of: dissolving a cerium-containing compound and urea in deionized water to obtain a solution, thoroughly stirring and pouring the solution into a hydrothermal kettle and carrying out microwave hydrothermal treatment; cooling to obtain a sediment; washing, drying and calcining the sediment; dissolving spherical shell type CeO2 powder in a mixed solution of a platinum-containing compound and a copper-containing compound, stirring and filtering to obtain a sediment; washing, drying and calcining the sediment to obtain the powdered spherical shell type catalyst Pt / CuO-CeO2. The catalyst prepared by the method has a good dispersibility, a unique spherical shell type appearance and a large specific surface area, so that pollutants can be attached to the surface of the catalyst favorably; besides, a large quantity of active sites can be provided; by the combination of noble metal and rare earth elements, the defects such as easy toxication and incapability of resisting high temperature are effectively overcome. The catalyst has very high catalytic activity to the catalytic combustion reaction of benzene series materials such as methyl benzene; in addition, raw materials for preparation are easy to obtain and the technology is simple.

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inbhibitors, NSAIDs, taxanes and platinum containing compounds use broader language.

The invention discloses a preparation method for a ceramic precursor binder allowed to be cured at the room temperature. The preparation method comprises the following steps: firstly, adding metallic sodium and methylbenzene in a three-mouth flask with a condensation flux device and a mechanical stirring device; heating the mixture to 80-120DEG C under the protection of inert gases, and dropping methyl dichloresilane; after the dropping is finished, preserving the heat at the temperature of 80-120DEG C for 4-12 hours, filtering, distilling and removing an organic solvent to obtain liquid polysilane; secondly, performing heat preservation on the liquid polysilane and 2,4,6,8-tetramethyl-2,4,6,8-tetravinyl cyclotetrasiloxane at the temperature of 80-160DEG C under the protection of the inert gases for 1-6 hours to obtain a liquid siloxane polycarbonate precursor; thirdly, uniformly mixing the liquid siloxane polycarbonate precursor with boron carbide powder, glass powder and a compound containing platinum to obtain the ceramic precursor binder. By using the preparation method disclosed by the invention, the ceramic precursor binder which can be cured at the room temperature and has excellent temperature resistance and binding performance can be prepared.

New polymer electrolytes were prepared by in situ cross-linking of allyl functional polymers based on hydrosilation reaction using a multifunctional silane cross-linker and an organoplatinum catalyst. The new cross-linked electrolytes are insoluble in organic solvent and show much better mechanical strength. In addition, the processability of the polymer electrolyte is maintained since the casting is finished well before the gel formation.

The invention belongs to the technical field of photocatalytic materials, and discloses a platinum metal loaded carbon nitride film, and a preparation method and an application thereof. The preparation method provided by the invention comprises the following steps: S1, placing a carbon nitride precursor into a crucible, and placing a carrier above the crucible; S2, calcining the crucible of the step S1 so as to obtain a graphite-phase carbon nitride film loaded on the carrier; and S3, impregnating the graphite-phase carbon nitride film obtained in the step S2 into a platinum-containing compound solution, and carrying out reducing so as to obtain a platinum metal loaded graphite-phase carbon nitride film with high water flux. According to the invention, through high-temperature evaporationcoating to the carbon nitride precursor, carbon nitride is uniformly coated onto the carrier, wherein cyanoguanidine and 2,6-diaminopyridine are preferably selected to form a precursor; and through animpregnation-reduction method, platinum metal particles are loaded onto the surface of a carbon nitride film to obtain the carbon nitride film with high water flux, stronger visible-light absorptioncapability and excellent photocatalytic degradation activity to aniline sewage, wherein the carbon nitride film can completely degrade aniline in one hour.

The invention provides a preparation method of a xylene isomerization catalyst. The method comprises the following steps: acid modified ZSM-5 molecular sieve and aluminum oxide are mixed and moulded, drying and calcination are carried out, in order to obtain a carrier, a solution of a platinum containing compound is used for dipping the carrier, drying, calcination and reduction are carried out, and the catalyst is prepared; a preparation method of the acid modified ZSM-5 molecular sieve comprises the following steps: after ammonia exchange, the ZSM-5 molecular sieve is dipped with a hydrochloric acid or nitric acid solution for 2-14 hours, and washing and drying are carried out. The catalyst prepared by the method is used for isomerization reactions of C8 aromatic hydrocarbons, and higher isomerization activity is obtained.

A sulfuration modification method of a xylene isomerization catalyst includes the following steps: uniformly mixing a ZSM-5 molecular sieve with a binder, forming, drying, roasting, carrying out ammonium exchange, dipping the obtained substance in a platinum-containing compound solution, drying, roasting, reducing, and carrying out gas phase sulfuration on the obtained roasted substance by a sulfur-containing compound in the presence of hydrogen. A xylene isomerization catalyst modified by the sulfur-containing compound through the method can be used in a xylene isomerization reaction, can inhibit disproportionation side reactions, and can realize high yield of xylene.

The invention discloses fire-resistant polysiloxane composition and application thereof. The composition is prepared from the materials of 100 to 150 parts of polysiloxane base body, 40 to 90 parts of oxide, 0 to 75 parts of phosphoric acid and / or phosphate, 0 to 18 parts of zinc borate, 0 to 1 part of catalyst, 1 to 3 parts of peroxide crosslinking and 0 to 28 parts of reinforcing agent, wherein the catalyst is selected from one of rhodium-containing compound, platinum-containing compound and iridium-containing compound or a mixture of the rhodium-contained compound, the platinum-contained compound and the iridium-contained compound. According to the fire-resistant polysiloxane composition, a production technology is simplified, and energy is remarkably saved; the fire-resistant polysiloxane composition has insulation property, filling property, oxygen insulation property, fire insulation property, thermal insulation property, flame resistance, fireproof property and fire resistance, is mainly applied to new-energy electric vehicles, can remarkably reduce loss of the new-energy electric vehicles on fire, also can be used for manufacturing an insulator or a filling body or an oxygen insulation body or a fireproof body or an inner protection layer of a cable, can be used as a thermal-insulation, fireproof and heat-preservation material of aircrafts, ships, warships, high-speed rails and buildings, and has good application prospect.

Multinuclear platinum compounds, compositions that include the platinum compounds, methods for making the platinum compounds, and methods for treating cellular proliferative diseases by administering the platinum compounds.

The invention discloses an oxidation-state reforming catalyst and a preparation method thereof. The preparation method comprises the following steps that step 1, a stannous alumina carrier is prepared; step 2, the carrier in step 1 is impregnated, the impregnation temperature is 10-50 DEG C, and an impregnation solution contains a platinum-containing compound, a rare earth compound, a competitiveadsorbent and a nitrogen-containing compound; step 3, the carrier impregnated in step 2 is dried and activated to obtain the reforming catalyst; the total mass of the dry-based alumina carrier is taken as a reference, and the reforming catalyst is prepared from, by mass, 0.1-0.4% of platinum, 0.1-0.6% of stannum, 0.05-1% of rare earth and 0.3-3.0% of chlorine. The catalyst is used for a hydrocarbon catalytic reforming reaction, can reduce the generation of coke, and improve the selectivity of product arene.

The invention discloses a light alkane dehydrogenation catalyst. The light alkane dehydrogenation catalyst comprises 0.1 to 7.0% by mass of Pt and 93 to 99.9% by mass of nano-diamond. The preparation method comprises roasting the nano-diamond in inert gas at 1000 to 1400 DEG C, immersing the nano-diamond in a platinum-containing compound solution, drying the nano-diamond in air and then reducing the nano-diamond. The catalyst is used for light alkane dehydrogenation and has high activity and stability.

The invention belongs to the technical field of synthesis of a platinum catalyst, and particularly relates to a platinum-containing hydrosilylation catalyst with a metal ion interference resistant function as well as preparation and an application. A platinum-containing compound and an organo-siloxane ligand containing double bonds are subjected to a reaction to synthesize an organo-siloxane complex of platinum, a functional organic compound with a crown-ether-like structure is added, and the platinum-containing hydrosilylation catalyst with the metal ion interference resistant function is obtained, wherein the functional organic compound with the crown-ether-like structure has a structure represented as a formula I. With the adoption of the platinum-containing hydrosilylation catalyst with the metal ion interference resistant function, the problems that the stability becomes poorer, the catalyst is prone to poisoning, inactivation and precipitation of platinum black and the like when a traditional platinum-containing hydrosilylation catalyst is contacted with a few heavy metal ions are solved effectively; the catalyst is good in stability, can be stored for a longer time and saves use cost.

The invention provides formulations for the organoplatinum anticancer drug picoplatin. Self emulsifying compositions, stabilized nanoparticulate compositions, solid dispersions, and nanoparticulate suspensions in oils are provided, along with methods for preparation of the formulations. The formulations can provide improved oral availability of picoplatin relative a to a simple solution of picoplatin such as in water or normal saline solution and can be used in combination therapy.

A method for treatment of small cell lung cancer (SCLC) that does not respond to first-line treatment or that progresses following cessation of first-line organoplatinum chemotherapy is provided that includes the administration of picoplatin, optionally in conjunction with a regimen of best supportive care. Multiple doses of picoplatin can be administered. The picoplatin can also treat SCLC that has metastacized to the brain.

The invention relates to a preparation method of a Pt-based multi-component alloy nano electrocatalyst, which comprises the following steps: weighing a platinum-containing compound, an X metal salt and a Y metal salt according to the target composition, and dissolving in deionized water to form a solution in which metal ions are dissolved, with X and Y being base metals; adding a proper amount ofweakly alkaline substances into the solution, with the alkalinity of the weakly alkaline substances being smaller than that of ammonia water; adding a carrier or a sacrificial template into the solution, and uniformly dispersing; reacting the solution at a proper temperature for a period of time to form Pt-XY hydroxide, and loading the Pt-XY hydroxide on the carrier or the sacrificial template; and carrying out heat treatment on the Pt-XY hydroxide in a reducing atmosphere to form the Pt-XY alloy catalyst supported on the carrier or the sacrificial template. The dispersity and the performanceof the metal particles are improved.

The invention discloses an anti-microbial and anti-mildew steaming pad. The anti-microbial and anti-mildew steaming pad comprises glass fiber cloth and a mixed silica gel layer wrapping the surface of the glass fiber cloth. The mixed silica gel layer is prepared from, by weight, 50-70 parts of siloxane simethicone, 10-20 parts of hydroxyl silicone oil, 15-25 parts of dimethoxydimethylsilane, 20-30 parts of titanium dioxide, 5-10 parts of talcum powder, 6-8 parts of an additive, 5-7 parts of trioctyl citrate, 0.01-0.03 part of an organoplatinum complex and 2-4 parts of paraffin oil. In the preparation process of the additive, chitosan is dissolved in an acetic acid aqueous solution, ethyl alcohol is added and mixed evenly, benzaldehyde is dropwise added, the mixture is heated, stirred and subjected to reduced pressure distillation, and a material A is obtained; the material A is purified, and a material B is obtained; the material B, L-lactide and stannous octoate are added into petroleum ether and mixed evenly, the mixture is heated under the nitrogen atmosphere, stirred in a heat preservation mode and purified, and a material C is obtained; the material C is added into a hydrochloric acid aqueous solution to be soaked, the mixture is filtered, a filter cake is taken, and the additive is obtained.

The present invention relates to conjugates of formula (I) having colloidal stability in a medium, wherein NP is a gold, silver or platinum nanoparticle; L is a linker selected from the group consisting of formula (II), formula (III), and a stereoisomer of any of the formulas (II) and (III), which is attached to the nanoparticle NP through sulfur atoms; wherein the meanings of X, n, p, Y and s are further specified in the description; and A is a platinum (II) biradical selected from the group consisting of formula (IV), formula (V) and formula (VI) including any of the stereoisomers of all of them, wherein the biradical is optionally in the form of a salt and is attached to the linker L through the single bonded oxygen atoms of the carboxyl groups. It also relates to a process for the preparation of the conjugates of formula (I) and to pharmaceutical compositions containing them. The conjugates of the invention are used for the treatment of cancer.

The invention belongs to the field of preparation of low-carbon alkane dehydrogenation catalysts, and particularly relates to a platinum-based catalyst taking hexagonal boron-carbon-nitrogen as a carrier and a preparation method thereof. The catalyst specifically comprises 1.0-10.0% by mass of platinum and 90-99% by mass of hexagonal boron carbon nitrogen. The specific preparation method comprises the following steps: mixing a boron source, a nitrogen source and a carbon source according to a ratio of 1: 1-10: 1-10, roasting the mixture in inert gas at 900-1400 DEG C to obtain a hexagonal boron-carbon-nitrogen crude body, washing the hexagonal boron-carbon-nitrogen crude body with hydrochloric acid with a certain concentration to obtain a hexagonal boron-carbon-nitrogen pure body, dipping the hexagonal boron-carbon-nitrogen crude body with a platinum-containing compound solution, drying in inert gas, and reducing. The obtained catalyst is used for light alkane dehydrogenation reaction and has high activity and stability.

A multi-metal catalyst for naphtha reforming is disclosed. The catalyst comprises a composite carrier and active components the contents of which are calculated based on the carrier. The active components comprise 0.04-3.0% by mass of platinum, 0.04-5.0% by mass of a VIIB-group metal, 0.01-3.0% by mass of a third metal component and 0.5-5.0% by mass of a halogen. The third metal component is selected from rare earth elements, indium or yttrium. The composite carrier comprises 0-80% by mass of gamma-aluminium oxide and 20-100% by mass of mesoporous gamma-aluminium oxide. A preparing method of the mesoporous gamma-aluminium oxide includes dipping amorphous mesoporous aluminium oxide with a solution of a platinum-containing compound, filtering to obtain solid, drying the solid and calcinating at 300-700 DEG C. A template is poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer. The mole ratio of the template to an aluminum source compound is 1:1-200. The mole ratio of aliphatic alcohol to the aluminum source compound is 20-100:1. The catalyst is used for naphtha reforming and is high in isomerization activity and good in aromatization selectivity.

The invention relates to a tridentate ligand modified silica gel immobilized platinum-containing hydrosilylation catalyst and a preparation method thereof, and is characterized in that a tridentate ligand reacts with surface hydroxylated silica gel to obtain tridentate ligand modified silica gel, and then the tridentate ligand modified silica gel reacts with a platinum-containing compound to obtain the tridentate ligand modified silica gel immobilized platinum-containing hydrosilylation catalyst. The tridentate ligand modified silica gel immobilized platinum-containing catalyst is obtained. The preparation method has the advantages that after modification and immobilization, the chemical stability and the thermodynamic stability are good, and the mechanical strength is high; the used organic tridentate ligand is cheap and easily available, and the overall preparation cost of the catalyst is low; the catalyst can efficiently catalyze an addition reaction of n-octene and triethoxysilane,the conversion rate is greater than 99%, the product selectivity is greater than 95%, and a high-yield beta addition product is obtained. The catalyst can be easily separated from a reaction system in a filtering or centrifuging manner, and can be recycled.

The invention provides a method of preparing a Pt / KL catalyst for alkane aromatization by using spongy platinum as a platinum source. The method comprises the following steps: using the spongy platinum with a relatively-low price and a wide range of sources as the platinum source, dissolving the spongy platinum by using aqua regia to obtain a spongy platinum solution, adding distilled water for aplurality of times, and performing heating concentration for a plurality of times until no acid mist is generated; adding a reducing agent at room temperature, performing heating to 20-100 DEG C, andperforming a reaction to obtain a wine red acidic solution containing divalent Pt elements; performing heating to boiling, and supplementing an alkaline substance until the solution becomes colorlessand transparent; and supplementing water or performing concentration for a plurality of times until the pH of the solution is 7-12, adding KL zeolite, performing impregnation under stirring at room temperature, performing drying, and performing calcination to obtain the Pt / KL zeolite molecular sieve catalyst for alkane aromatization. The method provided by the invention can fully solve the problemthat a current effective platinum-containing compound required for preparing a Pt / KL catalyst for aromatization lacks sources and is expensive, and the prepared Pt / KL catalyst has excellent alkane aromatization activity.

The present invention relates to conjugates of formula (I) having colloidal stability in a medium, wherein NP is a gold, silver or platinum nanoparticle; L is a linker selected from the group consisting of formula (II), formula (III), and a stereoisomer of any of the formulas (II) and (III), which is attached to the nanoparticle NP through sulfur atoms; wherein the meanings of X, n, p, Y and s are further specified in the description; and A is a platinum (II) biradical selected from the group consisting of formula (IV), formula (V) and formula (VI) including any of the stereoisomers of all of them, wherein the biradical is optionally in the form of a salt and is attached to the linker L through the single bonded oxygen atoms of the carboxyl groups. It also relates to a process for the preparation of the conjugates of formula (I) and to pharmaceutical compositions containing them. The conjugates of the invention are used for the treatment of cancer.

The invention discloses a continuous reforming catalyst and a preparation method thereof. The method comprises the following steps that 1, a tin-containing alumina carrier is prepared; 2, an impregnation liquid is prepared, wherein the impregnation liquid comprises a platinum-containing compound, a competitive adsorbent and a nitrogen-containing compound; 3, the carrier in step 1 is impregnated, and the impregnation liquid is evaporated, wherein the evaporation temperature is 50-60 DEG C; 4, a catalyst is dried, activated and reduced to obtain the polymetallic reforming catalyst. Calculated with the carrier as a reference, the obtained reforming catalyst comprises, 0.01-0.4 mass% of Pt, 0.01-0.6 mass% of Sn and 0.3-3.0 mass% of Cl, wherein the Pt dispersion degree, measured by means of a hydrogen-oxygen titration approach, of the catalyst is equal to or higher than 90%. The catalyst is used for hydrocarbon catalytic reforming reactions and has good activity and selectivity and a low carbon deposition rate.

A method for treatment of small cell lung cancer (SCLC) that does not respond to first-line treatment or that progresses following cessation of first-line organoplatinum chemotherapy is provided that includes the administration of picoplatin, optionally in conjunction with a regimen of best supportive care. Multiple doses of picoplatin can be administered. The picoplatin can also treat SCLC that has metastacized to the brain.

The invention discloses a fuel cell cathode oxygen reduction catalyst as well as a preparation method and application thereof, the catalyst takes TiN nanoparticles coated with a porous carbon layer on the surface as a carrier, and Pt particles are loaded on the exposed TiN surface of the porous carbon layer. a titanium-containing precursor and a nitrogen-containing carbon precursor are uniformly mixed to obtain mixed powder; heat treatment is carried out on the mixed powder in a vacuum environment, and then grinding treatment is performed to obtain a catalyst carrier coated with a porous carbon layer; and the catalyst carrier is mixed with a platinum-containing compound, and reducing is performed to obtain the composite catalyst loaded with Pt particles. The fuel cell cathode oxygen reduction catalyst has the advantages of long service life, acid resistance, high temperature resistance, corrosion resistance and excellent electrochemical performance.