Connexin core sequence-containing amphiphilic polypeptide and application thereof

An amphiphilic, fibrous material technology, applied in the medical and biological fields, which can solve the problems of poor biological activity, immunogenicity, and poor biodegradability
CN102115498BInactive Publication Date: 2013-11-06XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Publication Date
2013-11-06
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides connexin core sequence-containing amphiphilic polypeptide AcN-RADARADARADARADAGGDHLSDNYTLDHDRAIH-CONH2, wherein the amphiphilic polypeptide and the amphiphilic polypeptide with the structure of AcN-RADARADARADARADA-CONH2 are triggered by Ca2+or a cell culture medium DMEM-F12 to automatically form into a compound, i.e. a nanometer-grade fiber material, and the nanometer-grade fiber material is taken as a bracket of the bone mesenchymal stem cells, so that the biological behavior of the cells can be obviously improved, the degenerated intervertebral disc can be repaired, and the original height can be recovered.
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Description

Technical field:

[0001] The present invention belongs to medicine and biotechnology, and relates to an amphiphilic polypeptide containing a connexin core sequence and its application in medicine. Background technique:

[0002] Intervertebral disc degeneration (IVD) is the leading cause of low back pain, and studies show that 60%-80% of people will experience low back pain at least once in their lifetime. The main manifestation of intervertebral disc degeneration is that the water content of the nucleus pulposus decreases, the tension of the nucleus pulposus decreases, and the height of the intervertebral disc decreases. At the same time, hyaluronic acid and keratin sulfate decreased, low-molecular-weight glycoproteins increased, fibrillar degeneration and collagen fiber deposition increased, the nucleus pulposus lost elasticity, and the intervertebral disc structure was relaxed. Once this degeneration occurs, it will fall into a vicious circle and further aggravate the dege...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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