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Quality detection method for chinarue cough particle

A technology of cough and asthma detection method of Shijiao grass, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., and can solve the problems of many medicinal materials and no detection items of Shijiao grass

Active Publication Date: 2011-12-28
唐秋海
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing inspection quality standard stipulates the TLC identification of our tangerine peel, asparagus, and emodin, and the high-performance liquid chromatography is used to measure hesperidin in tangerine peel, one of the main ingredients in the prescription, but this prescription contains medicinal materials Many, and, one of the main components of the pepper grass has not been tested

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The detection method of Shijiaocao Kechuan granule of the present invention is as follows:

[0020] 1. Identification:

[0021] (1) Take 10g of the contents of this product, add 30ml of water to dissolve, and pass through D 101 Type macroporous resin column was eluted with 200ml of water, discarded the eluent, followed by elution with 50ml of 30% ethanol, discarded the eluent, and then eluted with 150ml of 50% ethanol, collected the eluent, and steamed until no alcohol smell ; Shake and extract three times with n-butanol saturated with water, each time being 40ml, 20ml, 20ml respectively, and combine the n-butanol liquid; wash twice with n-butanol-saturated water, each time being 20ml, 20ml respectively, discard the water washing solution, the n-butanol liquid was evaporated to dryness, and the residue was dissolved in 2ml of methanol as the test solution; another hesperidin reference substance was added to methanol to make a saturated solution as the reference substan...

Embodiment 2

[0032] Steps (1), (2) and (3) in the identification item are the same as those in Embodiment 1.

[0033] (4) Take 10g of the content of this product, heat 40ml of water to dissolve it, let it cool, adjust the pH to 10-11 with ammonia test solution, transfer it into a separatory funnel, and extract it with dichloromethane three times, each time: 30ml, Combine 20 ml and 20 ml of dichloromethane solution, evaporate to dryness, add 1ml of dichloromethane to the residue to dissolve, and use it as the test solution; take 2 g of the reference herb of Shijiaocao, decoct it with water for 1 hour, filter, and take the filtrate for use Adjust the pH of the ammonia test solution to 10-11, and use the same method as the content to prepare the test solution to prepare the control medicinal material solution; draw 10 μl of each of the above two solutions, and place them on the same silica gel G thin-layer plate respectively, and use normal Alkane-chloroform-methanol is 10: 3:0.5 volume ratio...

Embodiment 3

[0038] Steps (1), (2) and (3) in the identification item are the same as those in Embodiment 1.

[0039] (4) Take 10g of the content of this product, heat 40ml of water to dissolve it, let it cool, adjust the pH to 10-11 with ammonia test solution, transfer it into a separatory funnel, and extract it with dichloromethane three times, each time: 30ml, Combine 20 ml and 20 ml of dichloromethane solution, evaporate to dryness, add 1ml of dichloromethane to the residue to dissolve, and use it as the test solution; take 2 g of the reference herb of Shijiaocao, decoct it with water for 1 hour, filter, and take the filtrate for use Adjust the pH of the ammonia test solution to 10-11, and use the same method as the content to prepare the test solution to prepare the control medicinal material solution; draw 10 μl of each of the above two solutions, and place them on the same silica gel G thin-layer plate respectively, and use normal Alkane-chloroform-methanol is 15: 11:1.5 volume rati...

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PUM

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Abstract

The invention relates to a quality detection method for chinarue cough particles. In the formula, the chinarue cough particles include following materials: 156g of pericarpium citri reticulatae, 96g of rhizoma acori graminei, 312g of polygonum cuspidatum, 188g of asparagus cochinchinensis, 375g of chinarue, 96g of radix stemonae, 750g of marsdenia tenacissima, 375g of laggera pterodonta, 96g of semen armeniacae amarae, 375g of houttuynia cordata and 188g of cortex mori radicis, and the materials are prepared into particles. On the basis of the original standard, the thin-layer chromatography identification of the chrinarue is added, and the chinaure is one of main ingredients. After the thin-layer indentification of the chinaure is added on the basis of the original standard, the scientific basis is provided for qualitative control of the chinaure in the preparation, the quality detection standard of the chinaure cough particles is perfected, and the scientific basis is provided for the judgment of true and false and quality control of the product. In the method, the test and the operation of samples are simple and convenient, and by the continuous verification test of negative interference and the like, free interfered negativeness, good repeatability, and strong specificity are verified and tested. The quality test standard is perfected, and the product quality control capability is promoted.

Description

technical field [0001] The invention relates to the technical field of drug testing, in particular to a quality testing method for Shijiaocaokechuan granules. Background technique [0002] Shijiaocao Kechuan Granule has the functions of clearing away heat and reducing phlegm, relieving cough and relieving asthma. It is used for cough with thick phlegm, dry mouth and itchy throat caused by lung heat, and phlegm-damp cough and asthma caused by acute and chronic bronchitis. The drug prescription of Shijiaocao Kechuan Granules is: 156g of tangerine peel, 96g of Shijiaopu, 312g of Polygonum cuspidatum, 188g of Asparagus, 375g of Shijiaocao, 96g of Baibu; 375g, Morus alba bark 188g. Preparation method: extract the volatile oil from the above eleven medicinal materials, Shichangpu, Fenglingdan, Shijiaocao, and Houttuynia cordata by steam distillation, collect the volatile oil, and set aside; the distilled aqueous solution is collected in a separate vessel; seven herbs such as medi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 唐秋海
Owner 唐秋海
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