Composition containing niclosamide and metaldehyde and compound suspension thereof

A technology of metaldehyde and spirulina, applied in biocides, biocides, molluscicides, etc., can solve the problems of difficulty in effectively controlling the prevalence of schistosomiasis, low efficacy of wettable powders, and easy pollution of the environment , achieve the effect of overcoming the problem of drug resistance, good molluscicide effect, and safe storage and transportation

Active Publication Date: 2011-10-19
JIANGSU ESSENCE AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented solution provides an effective way to kill oncobalt shellfish (Oncosis) without causing damage or harming other fishes living near them. It uses certain chemicals together rather than just one ingredient like methyl salicylic acid but still works well enough against this disease. Additionally, there are advantages such as being able to transport these solutions safely over long distances, having lower vapor pressure compared to wet-powders, making them safer from exposure during storage, and showing promise when combined with various substances like pesticides or herbicide agents.

Problems solved by technology

This patented technical problem addressed by this patents relating to controlling Schistocerca nematodes (Schi caterpillis) for protection against diseases like malaria or leishmania spread through their blood vessels called phagocytes. Current methods involve killing these parasites with snake bait alone without effective treatment options such as antibiotic therapy or chemical agents.

Method used

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  • Composition containing niclosamide and metaldehyde and compound suspension thereof
  • Composition containing niclosamide and metaldehyde and compound suspension thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: 15% spirulina + 1% metaldehyde suspending agent

[0019] In terms of mass percentage, spiroxamine 15%, metaldehyde 1%, fatty acid polyoxyethylene ether 2%, methylene bis-naphthalene sulfonate sodium salt 5%, calcium lignosulfonate 5%, ethylene glycol 5% %, 0.3% benzoic acid, 0.5% organic silicone defoamer, 0.2% Cathone, 0.3% xanthan gum, deionized water to make up to 100%. The components are uniformly mixed with a high-shear emulsifying disperser in this ratio, and ground to 2-3um by a multi-stage sand mill to obtain 15% spiroxamate + 1% metaldehyde SC.

Embodiment 2

[0020] Embodiment 2: 25% spirulina+1% metaldehyde suspending agent

[0021] In terms of mass percentage, 25% spiroxamine, 1% metaldehyde, 2% sodium lauryl sulfate, 5% sodium methylene bis-naphthalene sulfonate, 5% calcium lignosulfonate, ethylene glycol 5%, 0.3% benzoic acid, 0.5% organic silicone defoamer, 0.2% Cathone, 0.3% xanthan gum, deionized water to make up to 100%. The components are uniformly mixed with a high-shear emulsifying disperser in this ratio, and ground to 2-3um by a multi-stage sand mill to obtain 25% spiroxamate + 1% metaldehyde SC.

Embodiment 3

[0022] Embodiment 3: 30% spirulina + 1% metaldehyde suspending agent

[0023] In terms of mass percentage, spiroxamine 30%, metaldehyde 1%, alkylphenol polyoxyethylene ether 2%, polycarboxylate sodium salt 2%, methylene bis-naphthalene sulfonic acid sodium salt 3%, ethylene glycol 5% alcohol, 1% benzoic acid, 0.5% organosilicone defoamer, 0.2% Cathone, 0.2% xanthan gum, and grind to 2-3um by multi-stage sand mill to prepare 30% spiroxamate+1 % Metaldehyde SC.

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Abstract

The invention discloses a composition containing niclosamide and metaldehyde and a compound suspension thereof. The niclosamide and the metaldehyde are used as active ingredients of the composition, and the mass ratio of the niclosamide to the metaldehyde is (1-50):(1-10). The composition can be applied to preparation of medicaments for preventing and treating trematodiasis. The aqueous suspension containing the niclosamide and the metaldehyde comprises 1-50 percent of niclosamide, 1-10 percent of metaldehyde, 1-5 percent of wetting agent, 1-20 percent of dispersant, 1-10 percent of anti-freezing agent, 0.1-1 percent of preservative, 0.1-1 percent of pH regulator, 0.1-1 percent of defoaming agent, 0.1-2 percent of thickening agent and the balance of deionized water which complements the volume to 100 percent. The aqueous suspension has the advantages of large prevention and treatment spectrum, good oncomelania killing effect, nonuse of an organic solvent, low volatility, low toxicity,safety to people, animals and environments, low granularity, high suspension rate, convenience in use and obvious comprehensive and economic benefits.

Description

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Claims

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Application Information

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Owner JIANGSU ESSENCE AGROCHEM
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