A kind of phase change controllable embolic material and its preparation method

Abstract

The invention relates to an embolic material, particularly a phase-change-controllable embolic material applicable to medicine and a preparation method thereof. The phase-change-controllable embolic material is prepared from a temperature-sensitive polymer water solution and a mixed developer, and is characterized in that the mixed developer comprises Iohexol and iodized oil; the mass percent of the mixed developer in the liquid embolic material is 30-80%; and the iodized oil accounts for 3-60% (volume percent) of the embolic material liquid solution. When the ambient temperature reaches the body temperature, the phase-change-controllable embolic material precipitates into solid to perform the embolic function, and the imaging appearance of the solid in the operation is clear, so that the clinician can directly observe and determine the position and flow direction of the embolic material, thereby avoiding ectopic embolism and greatly enhancing the safety of the operation.

Description

technical field [0001] The invention relates to an embolic material, in particular to a phase-change controllable embolic material used in medicine and a preparation method thereof. technical background [0002] In medical treatment, transcatheter embolization is an important technique in interventional therapy and one of the three major techniques of interventional radiology. It is to controlly inject some artificial embolic materials into the supply vessels of lesions or organs or into the diseased blood vessels to make them occluded and interrupt the blood supply. In order to control bleeding, treat vascular lesions, tumors and eliminate the function of diseased organs Purpose. The embolic material used in embolization plays a very important role in the success of embolization, and can even be said to be the key to the embolization process. [0003] The name of the invention disclosed in the Chinese patent is "temperature-sensitive polymer, temperature-sensitive liquid ...

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Problems solved by technology

[0003] The name of the invention disclosed in the Chinese patent is "temperature-sensitive polymer, temperature-sensitive liquid embolic material and its preparation method", the publication number is CN1569909A, and the patent number is 200410037836.5 invention patent, which overcomes the liquid embolic material in the prior art There are two major disadvantages: one is the phenomenon of "sticky tube" during use; the other is that the material contains organic solvents, and iohexol is used as the developer of the product in its preparation components, which can theoretically meet the requirements of the product in clinical practice. However, it has obvious defects in actual clinical application an

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