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Application of tetrandrine in preparation of drug for prevention and/or treatment of depression

A technology for tetrandrine and a drug is applied in the application field of tetrandrine in the preparation of drugs for preventing and/or treating depression, can solve the problems such as no antidepressant effect of tetrandrine, and achieves strong pharmacological action, shortening The effect of exercising time and suppressing the drop in body temperature

Active Publication Date: 2013-07-03
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Later, further studies showed that tetrandrine has pharmacological effects such as anti-tumor multidrug resistance, immunosuppression, inhibition of platelet aggregation, and lowering blood sugar, but there is no research report on tetrandrine's antidepressant effect

Method used

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  • Application of tetrandrine in preparation of drug for prevention and/or treatment of depression
  • Application of tetrandrine in preparation of drug for prevention and/or treatment of depression
  • Application of tetrandrine in preparation of drug for prevention and/or treatment of depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0162] The preparation of embodiment 1 capsule

[0163] Mix 100 g of tetrandrine and 900 g of medicinal starch evenly, and directly pack into hard gelatin capsules, 0.2 g per capsule.

Embodiment 2

[0164] The preparation of embodiment 2 tablet

[0165] Mix 100g tetrandrine and 900g medicinal starch evenly, granulate with an appropriate amount of ethanol, granulate through a granulator, dry below 60°C, granulate, add an appropriate amount of magnesium stearate, mix evenly, and send it into a tablet machine Compressed into tablets, 0.2g per tablet.

Embodiment 3

[0166] The preparation of embodiment 3 granules

[0167] Mix 10g of tetrandrine, 1000g of medical starch, and 100g of powdered sugar evenly, granulate with appropriate amount of ethanol, dry, and pack separately, 5g per bag.

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Abstract

The invention discloses novel application of tetrandrine in preparation of a drug for prevention, alleviation and / or treatment of depression. A result of a test shows that tetrandrine has obvious anti-depression curative effects, can produce effects fast and has few toxic and side effects, and thus is a safe, efficient and stable anti-depression drug of which a preparation process is simple. Therefore, tetrandrine is suitable for industrialized production and is easy to be popularized. The invention provides a novel drug source for prevention and treatment of depression and its concurrent diseases, disorder or illnesses.

Description

technical field [0001] The invention relates to a medicine or health food for preventing, alleviating and / or treating neurological diseases of affective disorder, in particular to an antidepressant medicine or health food. Background technique [0002] Major depressive disorder is the main type of mood disorders. It is a common mental disease with high prevalence, high burden, high suicide, easy relapse, and easy disability. Depressed mood is the main manifestation, which may be accompanied by corresponding changes in thinking and behavior. [0003] The main clinical manifestations of depression are low mood, loss of interest, self-blame, decreased self-evaluation, and fatigue, etc., and there may be neuromotor hysteresis or agitation, often accompanied by symptoms such as decreased appetite and libido, early awakening, and weight loss. cognitive dysfunction. Depression is a common mental disease that seriously endangers the physical and mental health of human beings. Due ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4748A61P25/24A23L1/29A23L33/00
Inventor 高杉崔元璐胡利民高秀梅王强松
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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