Colloidal bismuth pectin compound and medicinal composition thereof, and preparation methods and application thereof

A technology of colloidal bismuth pectin and compounds, which is applied in the field of colloidal bismuth pectin compounds and their pharmaceutical compositions, as well as their preparation and application, and can solve problems such as rising and easy resistance to antibiotics

Active Publication Date: 2013-06-12
于学敏
View PDF8 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs that have been put into clinical trials mainly include antibiotics such as pyrazolone, metronidazole, amoxicillin, and clarithromycin, but epidemiological studies do not support that antibiotics can eradicate H. However, the incidence of gastrointestinal diseases has not decreased, but has been increasing year by year, and Hp is prone to resistance to antibiotics

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Colloidal bismuth pectin compound and medicinal composition thereof, and preparation methods and application thereof
  • Colloidal bismuth pectin compound and medicinal composition thereof, and preparation methods and application thereof
  • Colloidal bismuth pectin compound and medicinal composition thereof, and preparation methods and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Add 15g of potassium metabismuthate into 50ml of water, stir to disperse evenly, add 15ml of KOH (40%) into the suspension of potassium metabismuthate under stirring, stir well to dissolve completely. 22.5g of pectin was added into 250ml of 80°C hot water under stirring to make pectin glue. Add the potassium metabismuthate solution into the cement under stirring, react for 0.5-1.0h, cool to 20°C, measure the content, and directly use it to prepare its pharmaceutical composition, or spray dry it to make a dry powder, which is used to prepare its pharmaceutical composition.

Embodiment 2

[0047] Weigh 150g of dried orange peel (approximately equivalent to 22.5g of pectin), crush it, wash it with water several times until it is almost colorless, dry it, add it to 500ml of dilute hydrochloric acid solution, adjust the pH to 2-2.5, and heat to a temperature of 85°C. Keep warm for 0.5h, extrude the glue, concentrate to 200ml, add 80ml (30%) of potassium metabismuthate solution, stir, add an appropriate amount of alkali (KOH) and stir to adjust the pH to 10-10.5, cool down, measure the content, and directly use it in the preparation Its pharmaceutical composition, or spray-dried to make dry powder, used to prepare its pharmaceutical composition.

Embodiment 3

[0049] Prescription and preparation method of ten thousand colloidal pectin bismuth capsules (50mg / capsule). Prescription: Mucilage or dry powder equivalent to 3334g colloidal pectin bismuth dry powder, 200g microcrystalline cellulose, 200g starch, 200g dextrin, appropriate amount of starch paste. Mix microcrystalline cellulose, starch, and dextrin evenly, add them to the glue, stir and mix evenly, add 5000g of water-miscible organic solvents, stir well, dehydrate, granulate, dry in a fluidized bed, measure the content, and calculate the granules Heavy, bagged. Or add pharmaceutical excipients to pectin bismuth dry powder, mix evenly, add an appropriate amount of binder (2% starch paste: 95% ethanol = 4:1) to make a soft material, granulate, dry in a fluidized bed, measure the content, Calculate the weight of the grains and pack them into capsules.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a colloidal bismuth pectin compound and a medicinal composition thereof, and preparation methods and application of the compound and the composition thereof. The chemical name of the compound is low methoxylpoly-D-galacturonic acid bismuth potassium double salt, wherein the structure of the compound contains structural fragments of D-galacturonic acid methyl ester, D-galacturonic acid bismuth and D-galacturonic acid potassium. The compound and the medicinal composition thereof can be used for treating gastric and duodenal ulcer, chronic atrophic gastritis, chronic erosive gastritis, bellyache, abdominal distension, diarrhea and gastrointestinal mucosa hemorrhage, particularly helicobacter pylori-related gastrointestinal ulcer or inflammation, and can be used for preventing canceration of atrophic gastritis; and the compound and the medicinal composition thereof are combined with antibiotic, a proton pump inhibitor or H2 receptor antagonist, or combined with other bismuth salt type compounds, or are continuously and independently taken after triple therapy of a bismuth agent, or are used for eradicating the helicobacter pylori by increasing the dosage to 1-2times the conventional dosage.

Description

technical field [0001] The invention relates to a colloidal pectin bismuth compound, its pharmaceutical composition, preparation method and application. It belongs to the field of medicine. Background technique [0002] Since Australian scientists Barry Marshall and Robin Warren discovered that Helicobacter pylori (Hp) is a pathogenic bacterium of gastrointestinal diseases in 1983, new breakthroughs have been made in the research of drugs to kill Hp in vivo. Drugs that have been put into clinical trials mainly include antibiotics such as pyrazolone, metronidazole, amoxicillin, and clarithromycin, but epidemiological studies do not support that antibiotics can eradicate H. However, the incidence of gastrointestinal diseases has not decreased, but has been increasing year by year, and Hp is prone to resistance to antibiotics. h 2 Receptor antagonists and proton pump inhibitors inhibit gastric acid secretion, which is not conducive to the treatment of chronic atrophic gastri...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/732C08B37/06A61P1/04A61P1/12A61P1/14A61P1/00A61P29/00
Inventor 于学敏王振南韩琴于洋
Owner 于学敏
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap