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Dropping pills containing colloidal bismuth pectin

A technology of colloidal bismuth pectin and dropping pills is applied in the directions of medical preparations containing active ingredients, pill delivery, medical preparations without active ingredients, etc., and can solve the problems of poor stability and low bioavailability.

Active Publication Date: 2013-06-12
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the shortcomings of poor stability and low bioavailability of existing colloidal bismuth pectin preparations, the present invention has invented colloidal bismuth pectin inclusion complex drop pills

Method used

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  • Dropping pills containing colloidal bismuth pectin
  • Dropping pills containing colloidal bismuth pectin
  • Dropping pills containing colloidal bismuth pectin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The prescription for dropping pills is (by weight):

[0020]

[0021] Preparation:

[0022] 1. Prepare colloidal pectin bismuth inclusion compound according to the following method:

[0023] (1) In water or aqueous ethanol medium, react colloidal bismuth pectin with hydroxypropyl β-cyclodextrin in proportion, filter the resulting solution through a microporous membrane until clear, and separate the clathrate from the mixture ;or

[0024] (2) in solid form, reacting colloidal bismuth pectin with hydroxypropyl beta-cyclodextrin; or

[0025] (3) Colloidal bismuth pectin reacts with hydroxypropyl β-cyclodextrin for high-energy grinding.

[0026] 2. Grind the colloidal bismuth pectin inclusion compound through a 100-200 mesh sieve; grind and mix polyethylene glycol 6000, stearic acid, dipotassium hydrogen phosphate and potassium dihydrogen phosphate evenly, heat and melt on a water-soluble surface, and mix Uniform; add colloidal bismuth pectin inclusion compound into ...

Embodiment 2

[0028] The prescription for dropping pills is (by weight):

[0029] Colloidal bismuth pectin inclusion complex (colloidal bismuth pectin: hydroxypropyl β-cyclodextrin 2:3) 4g

[0030] Macrogol 6000 5g

[0031] Stearic acid 5g

[0032] Dipotassium hydrogen phosphate and potassium dihydrogen phosphate 0.2g

[0033] Appropriate amount of liquid paraffin.

[0034] The preparation method is the same as in Example 1.

Embodiment 3

[0036] The prescription for dropping pills is (by weight):

[0037]

[0038] The preparation method is the same as in Example 1.

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Abstract

The application relates to dropping pills, and in particular relates to dropping pills containing colloidal bismuth pectin clathrate compounds.

Description

technical field [0001] The present application relates to a dropping pill, specifically, a dropping pill containing a colloidal pectin-bismuth inclusion compound. Background technique [0002] Dropping pills have the following characteristics: 1. Simple equipment, convenient operation, beneficial to labor protection, short process cycle and high productivity; 2. Easy to control process conditions, stable quality, accurate dosage, short heating time, easy to oxidize and volatile After the medicine dissolves in the matrix, its stability can be increased; 3, the matrix holds a large amount of liquid medicine, so the liquid medicine can be solidified; 4, the drop pill prepared by solid dispersion technology has the characteristics of rapid absorption and high bioavailability. [0003] The clathrate has the following advantages: mask bad odor and reduce irritation; increase drug dissolution rate and bioavailability; improve drug stability. [0004] Colloidal bismuth pectin is a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/732A61K47/34A61K47/12A61P1/04
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD
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