Method for detecting free bismuth in colloidal bismuth pectin or preparation containing colloidal bismuth pectin

A technology of colloidal bismuth pectin and a detection method, which is applied in the field of free bismuth detection, can solve problems such as the inability to distinguish macromolecular colloidal bismuth pectin from free bismuth, and achieve high accuracy, high sensitivity, and good linear relationship.

Active Publication Date: 2019-07-09
SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] However, the final colloidal bismuth pectin or the bismuth content in the colloidal pectin-containing bismuth preparation als

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for detecting free bismuth in colloidal bismuth pectin or preparation containing colloidal bismuth pectin
  • Method for detecting free bismuth in colloidal bismuth pectin or preparation containing colloidal bismuth pectin
  • Method for detecting free bismuth in colloidal bismuth pectin or preparation containing colloidal bismuth pectin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Determination of free bismuth content in colloidal pectin bismuth bulk drug.

[0038] 1) Preparation of chromogenic solution: Take 5g of ascorbic acid and 25g of potassium iodide, put them in a 200ml volumetric flask, add 100ml of water, shake to dissolve, add 25ml of 1mol / L nitric acid solution, dilute with water and set the volume to the mark to make 2.5% ascorbic acid , Potassium iodide 12.5% ​​chromogenic solution.

[0039] 2) Preparation of bismuth reference substance solution: Take 275 mg of bismuth metal, accurately weigh it, put it in a 100 ml volumetric flask, add 6.4 ml of nitric acid to dissolve, dilute with water to the mark, and use it as a bismuth standard stock solution. Precisely measure 2ml of bismuth standard stock solution, put it in a 100ml volumetric flask, dilute to the mark with 1mol / L nitric acid solution, and make a solution containing about 55μg of bismuth per 1ml, as the bismuth standard solution. Precisely measure 5ml of bismut...

Embodiment 2

[0043] Embodiment 2: Determination of free bismuth content in colloidal pectin bismuth capsules (specification 40 mg, calculated as bismuth).

[0044] 1) Preparation of chromogenic solution: Take 2.5g of ascorbic acid and 12.5g of potassium iodide, put them in a 200ml volumetric flask, add 100ml of water, shake to dissolve, add 25ml of 1mol / L nitric acid solution, dilute with water and set the volume to the mark to make ascorbic acid-containing solution 1.25%, potassium iodide 6.25% color solution.

[0045] 2) Preparation of bismuth reference solution: Take 255 mg of bismuth metal, accurately weigh it, put it in a 100 ml volumetric flask, add 6.4 ml of nitric acid to dissolve, dilute to the mark with water, and use it as a bismuth standard stock solution. Precisely measure 2ml of bismuth standard stock solution, put it in a 100ml volumetric flask, dilute to the mark with 0.8mol / L nitric acid solution, and make a solution containing about 51μg of bismuth per 1ml, as the bismuth...

Embodiment 3

[0049] Embodiment 3: Determination of free bismuth content in colloidal pectin bismuth capsules (specification 50 mg, calculated as bismuth).

[0050] 1) Preparation of chromogenic solution: Take 10g of ascorbic acid and 50g of potassium iodide, put them in a 200ml volumetric flask, add 100ml of water, shake to dissolve, add 25ml of 1mol / L nitric acid solution, dilute with water and set the volume to the mark to make 5% ascorbic acid , Potassium iodide 25% chromogenic solution.

[0051] 2) Preparation of bismuth reference substance solution: Take 275 mg of bismuth metal, accurately weigh it, put it in a 100 ml volumetric flask, add 6.4 ml of nitric acid to dissolve, dilute with water to the mark, and use it as a bismuth standard stock solution. Precisely measure 1ml of bismuth standard stock solution, put it in a 100ml volumetric flask, dilute to the mark with 1mol / L nitric acid solution, and make a solution containing about 27.5μg of bismuth per 1ml, as the bismuth standard s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a method for detecting free bismuth in colloidal bismuth pectin or a preparation containing colloidal bismuth pectin. The method includes the following steps of: placing colloidal bismuth pectin or the preparation containing colloidal bismuth pectin in a plastic centrifuge tube, adding water to shake for no more than 1min, obtaining a colloidal solution with uniform dissolution, centrifuging the colloidal solution immediately, separating the supernatant, measuring the content of bismuth in the supernatant by complexometric titration or ultraviolet spectrophotometry, andcalculating the content of free bismuth in colloidal bismuth pectin or the preparation containing colloidal bismuth pectin. The method for detecting free bismuth in colloidal bismuth pectin or the preparation containing colloidal bismuth pectin, established by the invention, has the advantages of strong specificity, high accuracy, good repeatability, good linear relationship and high sensitivity,and can be used as a mass control method for free bismuth in colloidal bismuth pectin or the preparation containing colloidal bismuth pectin to effectively control the quality of products of colloidalbismuth pectin or the preparation thereof.

Description

technical field [0001] The invention belongs to the technical field of colloidal pectin bismuth quality control and relates to a method for detecting free bismuth in colloidal pectin bismuth or colloidal pectin bismuth-containing preparations. Background technique [0002] Colloidal bismuth pectin and its capsules are the first drugs produced by Taiyuan Hongxing Pharmaceutical Factory, the predecessor of Shanxi Zhendong Ante Biopharmaceutical Co., Ltd. The drug was first approved by the former Ministry of Health in July 1992 to be produced and launched by Taiyuan Hongxing Pharmaceutical Factory. [0003] The active ingredient of colloidal bismuth pectin capsules is yellow powder, which is insoluble in organic solvents such as ethanol, acetone, ether, etc. It can form a stable colloidal dispersion in water and form a gel in artificial gastric juice. Colloidal bismuth pectin and its capsules have been included in the second volume of the 2015 edition of the "Chinese Pharmacop...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N21/33G01N21/78G01N31/16
CPCG01N21/33G01N21/78G01N31/16
Inventor 李安平崔锋朱平秦正国姚利娜白洁张禄
Owner SHANXI ZHENDONG ANTE BIOPHARMACEUTICAL CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap