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Streptococcus lactis enteric-coated tablets inhibiting helicobacter pylori (HP) and preparation method thereof

A technology of nisin intestines and nisin, which is applied in the field of pharmaceutical R&D and preparation, can solve problems such as inability to effectively inhibit and kill HP in the gastrointestinal tract, gastrointestinal mucosal damage, and ulceration

Inactive Publication Date: 2019-08-02
伟日(山东)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The invention provides a nisin enteric-coated tablet for inhibiting Helicobacter pylori and its preparation method to solve the problems in the prior art that HP in the gastrointestinal tract cannot be effectively inhibited and killed, and the mucosal damage caused by the gastrointestinal tract Lesions and festering problems

Method used

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Effect test

Embodiment Construction

[0027] A nisin enteric-coated tablet for inhibiting Helicobacter pylori, consisting of nisin, colloidal bismuth pectin, furazolidone, spirulina, vitamin U, soybean lecithin, diethyl phthalate, polyacrylic acid resin 2 No., Tween-80, castor oil, polyethylene glycol-6000, xanthan gum, talcum powder and starch, wherein the parts by weight of each component are: 5-7 parts of nisin; 1-7 parts of colloidal bismuth pectin 2 parts; 0-3 parts of furazolidone; 0.5-0.75 parts of spirulina; 0.1-0.15 parts of vitamin U; ​​0.1-0.15 parts of soybean lecithin; 0.09 parts; Tween-800.07-0.09 parts; castor oil 0.01-0.02 parts; polyethylene glycol-6000 0.05-0.06 parts; xanthan gum 0.01-0.02 parts; talc powder 0.02-0.03 parts; starch 0.09-0.10 parts.

[0028]The mass content of the above-mentioned nisin is ≥55%. Nisin is a biological fermentation extract. Nisin as a carrier must be a food-grade strain, must be live nisin, and nisin is rich in Contains cationic surfactants and active ingredients a...

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Abstract

The invention provides streptococcus lactis enteric-coated tablets inhibiting helicobacter pylori (HP) and a preparation method thereof. The streptococcus lactis enteric-coated tablets are prepared from streptococcus lactis, colloidal bismuth pectin, furazolidone, spirulina, vitamin U, soybean lecithin, diethyl phthalate, polyacrylic acid resin No. 2, Tween-80, castor oil, polyethylene glycol-6000, xanthan gum, talc and starch. According to a formula, the streptococcus lactis is used as a main active ingredient for treating the helicobacter pylori; the spirulina is suitable for mucosa repair,regeneration and normal secretion of intestinal ulceration formed by helicobacter pylori pathogens; the soybean lecithin has the effects of nourishing the stomach, sterilizing and repairing gastric mucosae; the colloidal bismuth pectin has the effects of isolating gastric acid, protecting injured mucosae and killing the helicobacter pylori. The streptococcus lactis enteric-coated tablets providedby the invention achieves significant inhibiting and infiltrating effects for the treatment of the helicobacter pylori; meanwhile, the mucosal injury and ulceration of the gastrointestinal tract caused by the helicobacter pylori can be alleviated and repaired.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical R&D and preparation, in particular to a nisin enteric-coated tablet for inhibiting Helicobacter pylori and a preparation method thereof. Background technique [0002] Helicobacter pylori (HP) is a Gram-negative, microaerophilic bacterium that lives in various regions of the stomach and duodenum. It can cause mild chronic inflammation of the gastric mucosa, or even cause gastric and duodenal Ulcer and gastric cancer, pylori belongs to G-bacteria, the content of peptidoglycan is low, the peptidoglycan layer is thin, and the lipid content is high. The pathogenicity of pylori is usually related to the composition of its cell wall, and the composition of the cell wall of this strain is relatively complex It mainly includes proteins, phospholipids and lipopolysaccharides, which are very compact, and only allow small molecules with a molecular weight below 600Da to pass through; currently there are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K9/32A61P1/04A61P31/04A61K31/422A61K31/685A61K31/732A61K35/748
CPCA61K9/2846A61K31/422A61K31/685A61K31/732A61K35/748A61K38/164A61P1/04A61P31/04A61K2300/00
Inventor 许宸华陈卫良李波
Owner 伟日(山东)生物科技有限公司
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