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Microballoon with immobilized presented immune co-stimulation molecules and preparation method of microballoon

A technology of co-stimulatory molecules and microspheres, applied in chemical instruments and methods, carrier binding/immobilizing peptides, specific peptides, etc., can solve problems such as difficulty in ensuring product safety, difficulty in scaling up production scale, and restrictions on a large number of applications. Biocompatibility and biosafety, improve stimulation, save the effect of cumbersome process

Inactive Publication Date: 2012-10-10
XI AN JIAOTONG UNIV
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  • Summary
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Problems solved by technology

However, the use of liposomes has some problems in terms of encapsulation efficiency, stability, and targeted distribution. Moreover, due to the difficulty in expanding the production scale of conventional processes and the need to use a large amount of organic solvents, it is difficult to ensure the safety of the product, resulting in a large number of applications. restricted

Method used

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  • Microballoon with immobilized presented immune co-stimulation molecules and preparation method of microballoon
  • Microballoon with immobilized presented immune co-stimulation molecules and preparation method of microballoon
  • Microballoon with immobilized presented immune co-stimulation molecules and preparation method of microballoon

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Embodiment Construction

[0039] The invention provides a microsphere immobilized for presenting immune co-stimulatory molecules. see figure 1 Firstly, lipophilic protein and immune co-stimulatory molecule are expressed as a lipophilic fusion protein through genetic engineering, and then adhere to the surface of degradable micro-nanoparticles through the adsorption of lipophilic protein domain and hydrophobic material to become immune co-stimulatory protein. Molecule immobilization expresses and presents the vector. The immobilized T cell activation second signal is used to participate in the immune activation process, and the effective recognition and combination of the hydrophobic particles loaded with immune co-stimulatory molecules and the target cells is used to achieve immune activation.

[0040] In the above three links, the microspheres are required to be hydrophobic, good biocompatibility, and degradable materials. Among them, the hydrophobicity is to be able to adhere to the lipophilic prot...

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Abstract

The invention discloses a microballoon with immobilized presented immune co-stimulation molecules and a preparation method of the microballoon. The microballoon comprises a hydrophobic nanoscale or micron-sized microballoons, the immune co-stimulation molecules are presented on the surfaces of the microballoons and are connected with the microballoons through amphipathic protein or hydrophobic binding domains. The microballoon not only can serve as a co-stimulation molecule presenting portion of a novel artificial antigen presentation system, but also can be individually used as an immobilized immune co-stimulation factor for improving organism immunity activation effects.

Description

technical field [0001] The invention relates to the technical field of artificial antigen presentation, and relates to a microsphere for immobilized presentation of immune co-stimulatory molecules and a preparation method thereof. Background technique [0002] Cancer is the second most serious disease that threatens human health and life after cardiovascular disease in the world. With the rapid development of molecular biology, immunology and bioengineering technology, tumor immunotherapy is becoming the next step after tumor surgery and treatment. Another new treatment after radiotherapy and chemotherapy, the purpose of immunotherapy is to make the body produce an effective cell-mediated immune response to cure the disease. It is a very promising treatment method for infectious diseases and anti-tumor . [0003] It is generally believed that cellular immunity plays an important role in the body's anti-tumor immune response, with T lymphocytes as the core. The activation, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K17/08
Inventor 卢晓云李明川刘倩倩王蕾蕾张雅利
Owner XI AN JIAOTONG UNIV
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