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Novel micro-ecological modulator and preparation method thereof

The technology of a regulator and microorganism is applied in the field of pharmaceutical compositions for regulating the gynecological micro-ecological environment and the field of preparation thereof, and can solve the problems of intractable cure, recurrent attacks, and curing the symptoms but not the root cause.

Active Publication Date: 2012-11-28
JIANGSU TIANZHAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] BV is a common gynecological disease, often recurrent, difficult to cure, and seriously affects women's physical and mental health. For a long time, Western medicine has been committed to the selection of antibacterial drugs, but because BV is a disease caused by bacterial imbalance, the use of antibacterial drugs is considered It is a method that treats the symptoms but not the root cause

Method used

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  • Novel micro-ecological modulator and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 20g sorrel, 20g flavescens, 10g cnidium, 10g cork, 10g aloe, add 10 times the amount of water (w / v), soak for 1 hour, heat and decoct twice, the first time is 1 hour, the second time is 1 hour , combine the decoction, filter, concentrate to about 1:1 (that is, the volume ratio of medicinal material and medicinal liquid, v / v) clear paste. Add ethanol until the alcohol content reaches 70%, and let it stand for 24 hours. Filter and concentrate the filtrate to a 1:1 clear paste. Add 10 times the amount of water to the above clear paste, refrigerate at 4°C for 24 hours, and filter. The filtrate was concentrated to a 1:1 clear paste. Weigh 0.114g of ethylparaben and 0.38g of chlorhexidine acetate, add to the concentrated solution, stir and dilute to 380ml.

Embodiment 2

[0017] Take 10g of sorrel, 10g of Sophora flavescens, 5g of cnidium, and 5g of Cortex Phellodendri, add 10 times the amount of water (w / v), soak for 1 hour, heat and decoct twice, the first time for 1 hour, the second time for 1 hour, and fry together Liquid, filtered, concentrated to about 1:1 (that is, the volume ratio of medicinal materials to medicinal liquid, v / v) clear ointment. Add ethanol until the alcohol content reaches 70%, and let it stand for 24 hours. Filter and concentrate the filtrate to a 1:1 clear paste. Add 10 times the amount of water to the above clear paste, refrigerate at 4°C for 24 hours, and filter. The filtrate was concentrated to a 1:1 clear paste. Weigh 0.114g of ethylparaben and 0.38g of chlorhexidine acetate, add to the concentrated solution, stir and dilute to 380ml.

Embodiment 3

[0019] Take 6g of sorrel, 6g of Sophora flavescens, 3g of Cortex Phellodendri, 3g of Fructus Cnidii, and 1g of aloe vera, add 5 times the amount of water (w / v), soak for 1 hour, heat and decoct for 1.5 hours, pour out the extract, and then add 5 times the amount of water ( w / v), heated and decocted for 1 hour, combined the decoction, filtered, and concentrated to about 1:1 (that is, the volume ratio of the medicinal material to the medicinal liquid, v / v). Add ethanol until the alcohol content reaches 70%, and let it stand for 24 hours. Filter and concentrate the filtrate to a 1:1 clear paste. Add 10 times the amount of water to the above clear paste, refrigerate at 2°C for 24 hours, and filter. The filtrate was concentrated to a 1:1 clear paste. Weigh 0.114g of ethylparaben and 0.38g of chlorhexidine acetate, add them to the concentrated solution, stir and dilute to 380ml to obtain.

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Abstract

The invention discloses a micro-ecological modulator for external use in gynaecology and a preparation method thereof. The micro-ecological modulator comprises the following components: 10-20g of rumex acetosa, 10-20g of radix sophorae flavescentis, 5-10g of fructus cnidii, 5-10g of cortex phellodendri and 0-10g of aloe, and is prepared by the following steps of: adding 10 times of water (w / v), and soaking for 1 hour; heating and decocting twice, wherein 1 hour is for the first time, and 1 hour is for the second time; combining the decoction liquids, filtering and concentrating to obtain clear cream of about 1:1 (the volume ratio of the medicinal materials to the liquid medicine, v / v); adding ethanol until the alcohol content reaches 70%, and standing for 24 hours; filtering, and concentrating the filtrate to obtain clear cream of 1:1; adding 10 times of water into the clear cream; refrigerating at 4 DEG C for 24 hours, and filtering; concentrating the filtrate to 1:1 clear cream; adding 0.114g of ethylparaben and 0.38g of chlorhexidine acetate into the concentrated solution; and stirring and fixing the volume to 380ml. The micro-ecological modulator disclosed by the invention is a medicinal composition capable of inhibiting harmful germs and is used for regulating the micro-ecological balance in the vagina of a woman.

Description

Technical field [0001] The present invention involves a drug composition and its preparation method, which specifically involves a pharmaceutical composition and preparation method that regulates the gynecological micro -ecological environment. Background technique [0002] There are many normal microorganisms in the vagina of healthy women. It constitutes a micro -ecological balance with each other with the host and the environment, which brings comfort and joy to women's health. [0003] Women's vagina is a complicated is a micro -ecological system. Once the micro -ecological balance of the vagina is destroyed, the flora in the vagina will cause disorders and cause a variety of diseases.Bacterial vaginal disease (BV) is a syndrome of vaginal mucosal inflammation caused by the vaginal minimum ecological balance, anaerobic bacteria and vaginal Gednezal bacteria, and the inhibitory of the inhibitory of the inhibitory of the inhibitory.EssenceIt is a common vaginal infection diseas...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P15/02
Inventor 乐智勇夏培元刘丽玲董婧婧
Owner JIANGSU TIANZHAO PHARMA
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