N-acetyl-DL-leucine, neuroprotective and retinoprotective medicament

A leucine, protective technology for the production of neuroprotective and retinal protective drugs (or pharmaceuticals) that addresses issues such as the unknown potential for ophthalmic applications

Inactive Publication Date: 2013-05-01
拉乌夫·雷基克
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] Despite the beneficial effects of N-acetyl-DL-leucine on vertigo, its potential for ophthalmic applications was not known prior to this invention

Method used

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  • N-acetyl-DL-leucine, neuroprotective and retinoprotective medicament
  • N-acetyl-DL-leucine, neuroprotective and retinoprotective medicament
  • N-acetyl-DL-leucine, neuroprotective and retinoprotective medicament

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Experimental program
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Embodiment

[0162] The numerical indications given below should not be considered as limiting the invention per se, as they can be determined by the physician and his or her patient, the following daily doses of the active ingredient (e.g., N-acetyl-DL-leucine) It is effective when administered orally at a dose of 2 grams per day; or at a concentration of 2% when administered in the form of eye drops. It is clear that the dose may vary from patient to patient and that is ultimately a matter for the clinician.

[0163] Topical administration forms, especially eye drops, are clearly preferred here. They have proven to be particularly effective.

[0164] In other words, the active ingredient (for example, N-acetyl-DL-leucine) is combined with one or several pharmaceutical carriers enabling clinical use in the form of eye drops.

[0165] The invention can be further illustrated by the following description of clinical examples, which of course do not limit the invention per se. In these ex...

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PUM

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Abstract

The invention relates to a medicament, the active principle of which is a leucine and, for example, a N-ACETYL-DL-LEUCINE. It can be applied to the prevention and / or treatment of eye diseases or disorders and especially of hereditary dystrophies of the retina, glaucomatous neuropathy, glaucoma, macular degeneration, myopia, presbyopia, hypermetropia, astigmatism, all the ophtalmologic diseases or disorders inducing a decrease of visual function and / or age-related physiological vision decline.

Description

technical field [0001] The present invention relates to the production of medicaments, in particular neuroprotective and retinal protective medicaments (or medicaments) for the prevention and / or treatment of ocular diseases resulting in damage to the retina and optic nerve which can lead to vision (especially loss of near and far visual acuity, contrast vision, color vision and / or visual field). These drugs contain at least one active ingredient that is leucine, eg, N-acetyl-DL-leucine. This leucine can be combined with other active ingredients, especially Ramipril or Ramiprilate. Background technique [0002] The present invention aims to provide medicines for preventing and / or treating eye diseases or disorders, which can improve vision function, especially distance vision acuity and / or near vision acuity, contrast vision, Color vision and / or visual field. Examples of such diseases or disorders that may be mentioned are: [0003] - Inherited retinal dystrophies such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00A61K31/198A61P27/02
CPCA61K31/198A61K45/06A61P3/06A61P9/10A61P9/12A61P19/02A61P21/02A61P21/06A61P25/00A61P25/16A61P27/00A61P27/02A61P27/06A61P27/10A61P29/00A61P31/00A61P35/00A61P37/00A61P43/00
Inventor 拉乌夫·雷基克
Owner 拉乌夫·雷基克
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