Markers for the prognosis and risk assessment of pregnancy-induced hypertension and preeclampsia

A technology for preeclampsia and risk assessment, applied in the field of clinical diagnostics, can solve problems that have not explored the prognosis of ET-1 or the application of risk assessment

Inactive Publication Date: 2013-05-15
CEZANNE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, none of these studies explored the use of ET-1 as a marker for prognosis or risk assessment of pregnant women developing preeclampsia

Method used

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  • Markers for the prognosis and risk assessment of pregnancy-induced hypertension and preeclampsia
  • Markers for the prognosis and risk assessment of pregnancy-induced hypertension and preeclampsia
  • Markers for the prognosis and risk assessment of pregnancy-induced hypertension and preeclampsia

Examples

Experimental program
Comparison scheme
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Embodiment

[0067] research population

[0068] A total of 323 patients were included in the retrospective study. These patients were diagnosed with early-onset preeclampsia (n=25), late-onset preeclampsia (n=25), and pregnancy-induced hypertension (PIH) (n=25). 225 pregnant women without these diseases served as controls.

[0069] EDTA-samples were collected at each prenatal visit, which was performed between 11 and 14 weeks of gestation. At that time, all patients included in the study were asymptomatic and did not show any signs or symptoms of preeclampsia or PIH. All pregnant women gave informed consent approved by the King's College Hospital Ethics Committee.

[0070] If hypertension (systolic or diastolic blood pressure ≥140 and 90 mmHg, respectively) and proteinuria (protein excretion ≥300 mg in a 24-hour urine collection, or dipstick ≥2+) are detected after 20 weeks of gestation, the patient Have been diagnosed with preeclampsia. Based on the time of onset of preeclampsia, ...

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Abstract

The present invention relates to the prognosis and risk assessment in pregnant women to develop pregnancy-induced hypertension and / or preeclampsia by the determination of marker levels.

Description

technical field [0001] The invention belongs to the field of clinical diagnostics. In particular, the present invention relates to the prediction and risk assessment of developing gestational hypertension and / or preeclampsia in pregnant women by measuring the levels of markers. Background technique [0002] Hypertension is the most common medical problem encountered during pregnancy, complicating 2-3% of pregnancies. As recommended by the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy, hypertensive disorders during pregnancy are divided into 4 categories: 1) chronic hypertension, 2) preeclampsia-eclampsia, 3) preeclampsia plus chronic hypertension, and 4) pregnancy or gestational hypertension (gestational transient hypertension or chronic hypertension identified in the second half of pregnancy). Chronic hypertension is defined as blood pressure above 140 / 90 mmHg before pregnancy or before 20 weeks of gestation. Elevated bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/74
CPCG01N33/74G01N33/6893G01N2800/321G01N33/689A61B8/02G01N2800/368
Inventor 布鲁诺·达博莱特盖亚尼·德米尔吉安
Owner CEZANNE
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