RNA(Ribonucleic Acid)and application thereof in diseases of cardiovascular system

A technology in the heart and sequence listing, applied in cardiovascular system diseases, DNA/RNA fragments, applications, etc., can solve the problems of HIP-55 research reports and less understanding of HIP-55 functions
CN103114087BInactive Publication Date: 2015-05-06PEKING UNIV THIRD HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PEKING UNIV THIRD HOSPITAL
Publication Date
2015-05-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses RNA and application of RNA in diseases of a cardiovascular system. According to RNA, the nucleotide sequence of RNA is a sequence 3 in a sequence table. The invention further provides a gene,encoding RNA. The nucleotide sequence of the gene of RNA is a sequence 4 in the sequence table. The experiment of the invention shows that RNA and the application of RNA in the diseases of the cardiovascular system find that by an induction of isoproterenol (ISO), RNAi method Knock down IHP-55 is used in neonatal rat cardiac fibroblasts to obviously promote proliferation of cardiac fibroblasts; ISO induced activation and kinase activity of P38MAPK can be enhanced in the Knock-down HIP-55 cardiac fibroblasts; and HIP-55 is a new protein which has a protective effect on cardiac fibrosis, and provides a new target for clinical diagnosis, treatment and new medicament development.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to an RNA and its application in cardiovascular system diseases. Background technique

[0002] HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa; also known as drebrin-like protein, mAbp1 or SH3P7) is a protein containing a multifunctional domain. Its structure mainly includes the N-terminal F-actin protein binding domain and the C-terminal SH3 domain. HIP-55 is involved in synaptogenesis, receptor endocytosis, cytoskeleton rearrangement and signal transduction. At present, little is known about the function of HIP-55, and there is no research report on the role of HIP-55 in the cardiovascular system.

[0003] Cardiovascular disease is the "number one killer" of Chinese residents' health, and the annual direct medical expenses mainly for cardiovascular disease have reached 130 billion yuan. Myocardial fibrosis is an important pathological change of cardia...

Claims

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