Gastrodin double-pulse drug-release preparation

A technology of gastrodin and sub-pulse, which is applied in the directions of medical formula, drug combination, drug delivery, etc., can solve problems such as easy to wake up early, achieve the effect of solving easy early awakening, solving difficulty in falling asleep, and expanding the scope of application

Active Publication Date: 2014-12-03
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The gastrodin twice-pulse drug release preparation provided by the present invention expands the application range of gastrodin, a water-soluble drug with a short half-life, in the field of insomnia treatment, and can realize timed pulse release at the two most critical time points in the sleep process. It can also solve the problems of insomnia patients who have trouble falling asleep and wake up early, and ensure their sleep time and quality

Method used

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  • Gastrodin double-pulse drug-release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation of embodiment 1 gastrodin pulse release preparation twice

[0042] Ball core prescription:

[0043] Gastrodin 50g

[0044] Lactose 150g

[0045] Immediate-release pellet coating solution prescription:

[0046] Opadry 60g

[0047] water 300ml

[0048] Delayed-release pellet coating solution prescription:

[0049] Swelling layer:

[0050] Croscarmellose Sodium 80g

[0051] Hypromellose 20g

[0052] Water 8000ml

[0053] Lag layer:

[0054] Surelease 150ml

[0055] water 100ml

[0056] Preparation method: mix gastrodin and lactose fine powder (through 80-mesh sieve), add appropriate amount of water to make soft material, extrude into thin strips through the sieve plate of the extruder (aperture 0.8mm), put it in the spheronizer, and the speed is 1000rpm, spheronization time 4min, make the granules completely spheroidal, dry at 60°C, sieve with 20 mesh to sieve the granules to get the pellet core. Get the drug-loaded pellet core and adopt fluidi...

Embodiment 2

[0057] The preparation of embodiment 2 gastrodin pulse release preparations twice

[0058] Ball core prescription:

[0059] Gastrodin 50g

[0060] Microcrystalline Cellulose 100g

[0061] Immediate-release pellet coating solution prescription:

[0062] Hypromellose 50g

[0063] Dibutyl sebacate 15g

[0064] Ethanol 800ml

[0065] Delayed-release pellet coating solution prescription:

[0066] Swelling layer:

[0067] Low-substituted hydroxypropyl cellulose 30g

[0068] Hypromellose 30g

[0069] water 5000ml

[0070] Lag layer:

[0071] Ethyl cellulose 20g

[0072] Dibutyl sebacate 5g

[0073] Ethanol 400ml

[0074] Preparation method: mix gastrodin and microcrystalline cellulose fine powder (through 80-mesh sieve), add appropriate amount of water to make soft material, extrude into thin strips through extruder sieve plate (aperture 0.8mm), put in spheronizer , adjust the rotation speed and spheronization time to make the granules completely spheroidal, dry at 60°C...

Embodiment 3

[0075] The preparation of embodiment 3 gastrodin pulse release preparations twice

[0076] Ball core prescription:

[0077] Gastrodin 50g

[0078] Lactose 150g

[0079] Microcrystalline Cellulose 100g

[0080] Immediate-release pellet coating solution prescription:

[0081] Hypromellose 20g

[0082] Diethyl phthalate 3g

[0083] Ethanol 400ml

[0084] Delayed-release pellet coating solution prescription:

[0085] Swelling layer:

[0086] Carboxymethyl Starch Sodium 100g

[0087] Hypromellose 20g

[0088] water 9000ml

[0089] Lag layer:

[0090] Ethyl cellulose 50g

[0091] Diethyl phthalate 5g

[0092] Ethanol 800ml

[0093] Preparation method: mix gastrodin, lactose and microcrystalline cellulose fine powder (through 80 mesh sieve), add appropriate amount of water to make soft material, extrude into thin strips through the sieve plate of the extruder (aperture 0.6mm), and roll into a ball In the machine, adjust the rotation speed and spheronization time to mak...

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Abstract

The invention relates to the field of pharmaceutical preparation, and in particular relates to a gastrodin double-pulse drug-release preparation. The preparation consists of quick release pellets and slow-release pellets, wherein the quick release pellets consist of gastrodin quick release pellet cores and quick release layers, and the slow-release pellets consist of gastrodin slow-release pellet cores, swelling layers and time-lag layers. By utilizing the gastrodin double-pulse drug-release preparation provided by the invention, the application range of water-soluble medicinal gastrodin with short half-life period is widened in the insomnia treatment field, and the pulse drug release of the double-pulse drug-release preparation can be realized in two key time points at fixed times in an insomnia process; moreover, problems of difficulty in sleeping and early awakening of insomnia patients can be solved, and the sleeping time and quality are ensured.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a gastrodin double pulse release preparation. Background technique [0002] With the accelerated pace of life in today's society and the increase in mental stress, insomnia has become one of the ubiquitous sufferings of people, and it is one of the most common clinical symptoms except pain. Long-term lack of sleep will lead to daytime sleepiness and decreased concentration of patients, affecting physical and mental health and quality of life, and even depression in severe cases. According to the World Health Organization, nearly 1 / 4 of the world's population suffers from insomnia. According to the survey data of the Chinese Medical Association, the prevalence rate of sleep disorders in my country reaches 42.7%, and about 300 million middle-aged people suffer from sleep disorders. [0003] There are three main clinical manifestations of insomnia: first, difficulty in f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/62A61K31/7034A61K47/38A61P25/20
Inventor 蔡铮刘中秋杨兆祥张国丽张琪黄娟龚耘罗辉唐琪晶
Owner KPC PHARM INC
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