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Application of Chukrasone A in preparation of medicines for treating atherosclerosis

A technology for atherosclerosis and drugs, applied in the application field of Chukrasone A in the preparation of drugs for the treatment of atherosclerosis, which can solve the problems of no preventive measures and therapeutic drugs, and the etiology and pathogenesis have not yet been fully elucidated

Inactive Publication Date: 2013-10-30
丁圣雨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective preventive measures and therapeutic drugs.

Method used

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  • Application of Chukrasone A in preparation of medicines for treating atherosclerosis
  • Application of Chukrasone A in preparation of medicines for treating atherosclerosis
  • Application of Chukrasone A in preparation of medicines for treating atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of the compound Chukrasone A tablet involved in the present invention:

[0012] Take 20 grams of compound Chukrasone A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0013] Embodiment 2: the preparation of the compound Chukrasone A capsule involved in the present invention:

[0014] Get 20 grams of compound Chukrasone A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

[0016] The present invention discloses the effect of Chukrasone A on atherosclerosis through cell-level research and establishment of atherosclerosis models.

[0017] Oral and intravenous administration of Chukrasone A in the present invention can significantly reduce plaque area / intima area (%), intima thickness (um) / media thickness (%) in atherosclerotic rats; Triesters, total cholesterol and low-density lipoprotein levels decreased, indicating that Chukrasone A can treat atherosclerosis.

[0018] Materials and Methods

[0019] 1. Experimental materials:

[0020] 1.1 Animals and fe...

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Abstract

The invention discloses an application of Chukrasone A in the preparation of medicines for treating atherosclerosis. The Chukrasone A can play a role in resisting the atherosclerosis by regulating blood lipids and protecting endothelial cells. The medicines for resisting the atherosclerosis, which is prepared from the Chukrasone A, have relatively good curative effects on the atherosclerosis and can be used for resisting the atherosclerosis of people or animals. The application of the Chukrasone A in the preparation of the medicines for treating the atherosclerosis is disclosed by the invention for the first time. As the skeleton type of the Chukrasone A belongs to a bran-new skeleton type and the Chukrasone A has unexpected strong inhibitory activity on the atherosclerosis, the possibility that other compounds provide revelation does not exist. The Chukrasone A has prominently substantial characteristics and meanwhile has remarkably progressive significance when being used for resisting the atherosclerosis.

Description

technical field [0001] The invention relates to the application of Chukrasone A in the preparation of medicines for treating atherosclerosis. Background technique [0002] Cardiovascular and cerebrovascular diseases are the most serious diseases that endanger human health and life in the contemporary era. They are common and frequently-occurring diseases among middle-aged and elderly people. Atherosclerosis (AS) is the main pathological basis of cardiovascular and cerebrovascular diseases. So far, its etiology and pathogenesis have not been fully elucidated, so there are no concise and effective prevention measures and therapeutic drugs. [0003] The compound Chukrasone A involved in the present invention is published in 2012 (Liu, H. B. et al., 2012. Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia tabularis. Organic Letters 14 (17), 4438– 4441.), which has a new skeleton type, and its current use only involves potassium ion...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61P9/10
Inventor 丁圣雨
Owner 丁圣雨
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