A registration method for dynamic contrast-enhanced magnetic resonance image sequences of the breast

A magnetic resonance image and dynamic enhancement technology, applied in the field of medical medical image registration, can solve problems such as inability to guarantee time continuity, achieve the effects of reducing complexity and calculation, fast implementation, and improving estimation accuracy
CN103400376BActive Publication Date: 2016-04-06SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2016-04-06

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Abstract

The invention discloses a registering method of a breast dynamic contrast-enhanced magnetic resonance image (DCE-MRI) sequence. The registering method comprises the following steps of: (1) reading image data of all time frames on the same layer of the DCE-MRI sequence; (2) coarsely registering an image to be enhanced and an enhanced image to obtain an initial estimation value of a deformation field; (3) performing motion compensation on the DCE-MRI sequence, and calculating an enhancement field of each time point; (4) modeling, and solving a time sequence enhancement field; (5) de-enhancing the DCE-MRI sequence; (6) solving the deformation field; and (7) judging whether the solutions of the time sequence enhancement field and the deformation field converge or not; if the solutions do not converge, regarding the currently solved deformation field as the currently estimated deformation field, and performing the step (3); and if the solutions converge, registering the image sequence. The registering method is accurate in registering and small in calculation amount; the time sequence enhancement field can be estimated.
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Description

technical field

[0001] The invention relates to a registration method of medical images, in particular to a registration method of a breast dynamic enhanced magnetic resonance image sequence. Background technique

[0002] The registration method of Dynamic Contrast-Enhanced Magnetic Resonance Image (DCE-MRI) of the breast generally regards the MRI images before and after enhancement as images of different modalities, and then uses mutual information as a similarity measure to match the images before and after enhancement. allow.

[0003] Rueckert uses normalized mutual information as a similarity measure (RueckertD, SonodaLI, HayesC, HillDLG, LeachMO, HawkesDJ. Nonrigidregistrationusing free-form deformations: ApplicationtobreastMRImages.IEEETransactionsonMedicalImaging, 1999.18(8):p.712-721), with 3D rigid registration as Coarse registration results, and then use the free deformation model based on B-splines to describe the deformation field of the breast, and add the smoo...

Claims

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