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A new balisen glycoside compound from Gastrodia elata and its use

A technology of balisen glycosides and compounds, applied in the field of natural medicine and medicine, can solve the problems of unclear effect substances in brain diseases and other problems

Active Publication Date: 2016-03-30
JIANGXI HERBFINE HI TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its related varieties are mostly used clinically for related diseases caused by cerebrovascular injury. However, at present, gastrodin, the main active ingredient in Gastrodia elata, mainly has sedative and hypnotic effects, and its active substances for brain diseases are still unclear

Method used

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  • A new balisen glycoside compound from Gastrodia elata and its use
  • A new balisen glycoside compound from Gastrodia elata and its use
  • A new balisen glycoside compound from Gastrodia elata and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The preparation method of a new barison glycoside compound in Gastrodia elata is as follows:

[0051] 1. Extraction: After crushing the dried Gastrodia elata medicinal material, add 50% ethanol solution with a volume 8 times the weight of the medicinal material, heat and reflux at 70°C for 3 times, each time for 2 hours, combine the extracts, and concentrate to obtain the total extract;

[0052] 2. Rough fractionation: after the total extract obtained from the above extraction is dissolved in water 10 times the weight of the total extract, the mass ratio of Gastrodia elata medicinal material to resin is 1:1, and the AB-8 macroporous adsorption resin is used to dissolve the total extract with water. , 20% ethanol solution, 70% ethanol solution, 95% ethanol solution gradient elution, each gradient elution has four retention volumes, collect the eluted part of 70% ethanol solution, and concentrate under reduced pressure at 60°C to obtain a crude extract;

[0053] 3. Refini...

Embodiment 2

[0056] The preparation method of a new barison glycoside compound in Gastrodia elata is as follows:

[0057] 1. Extraction: After crushing the dried Gastrodia elata medicinal material, add 50% ethanol solution with a volume 8 times the weight of the medicinal material, heat and reflux at 75°C to extract 3 times, each time for 2 hours, combine the extracts, and concentrate to obtain the total extract;

[0058] 2. Rough fractionation: after the total extract obtained from the above extraction is dissolved in water 10 times the weight of the total extract, the mass ratio of Gastrodia elata medicinal material to resin is 1:1, and the AB-8 macroporous adsorption resin is used to dissolve the total extract with water. , 20% ethanol solution, 70% ethanol solution, 95% ethanol solution gradient elution, each gradient elution has four retention volumes, collect the eluted part of 70% ethanol solution, and concentrate under reduced pressure at 60°C to obtain a crude extract;

[0059] 3....

Embodiment 3

[0062] The preparation method of a new barison glycoside compound in Gastrodia elata is as follows:

[0063] 1. Extraction: After crushing the dried Gastrodia elata medicinal material, add 50% ethanol solution with a volume 8 times the weight of the medicinal material, heat and reflux at 80°C for 3 times, each time for 2 hours, combine the extracts, and concentrate to obtain the total extract;

[0064] 2. Rough fractionation: after the total extract obtained from the above extraction is dissolved in water 10 times the weight of the total extract, the mass ratio of Gastrodia elata medicinal material to resin is 1:1, and the AB-8 macroporous adsorption resin is used to dissolve the total extract with water. , 20% ethanol solution, 70% ethanol solution, 95% ethanol solution gradient elution, each gradient elution has four retention volumes, collect the eluted part of 70% ethanol solution, and concentrate under reduced pressure at 60°C to obtain a crude extract;

[0065] 3. Refini...

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Abstract

The present invention discloses a new parisonoside compound in Gastrodia elata and its application. Gastrodia? elata? B.I. ) is a new compound that can improve memory loss caused by cerebrovascular ischemia after extraction, purification, and structural identification. : Barisonoside? J (parishin? J).

Description

technical field [0001] The invention relates to a novel barisonoside compound in Gastrodia elata and its application, and belongs to the technical field of natural medicine medicine. Background technique [0002] Gastrodia elata is one of the most precious Chinese medicinal materials in my country, also known as Chijian, Chijianzhi, Duyaozhi, Dingfengcao, Limu, and Helicao. Gastrodia elata ( Gastrodiaelata BI. ) is a perennial parasitic plant whose host is Armillariamellea (Vahl. eXFr) Quel, which uses the mycelium or mycelial secretions of Armillaria mellea as a source of nutrition for growth and development. Born in moist forest and fertile soil. Distributed in Sichuan, Yunnan, Guizhou, Tibet and other places, it is now widely cultivated. According to the records of "Compendium of Materia Medica", it is pungent, warm, and non-toxic, and it is mainly used to treat rheumatic arthralgia, spasm of limbs, paralysis, dizziness and headache embolism. Its related varieties are...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/203C07H1/08A61K31/7034A61P25/28A61P9/10
Inventor 冯育林李志峰杨世林李俊欧阳辉王亚威王琦
Owner JIANGXI HERBFINE HI TECH
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