Composition for enhancing memory and its application

Abstract

The memory-enhancing composition and its application, the active ingredients of the composition are versicolor polysaccharide and ginkgo flavonoids. The polysaccharides from the medicinal fungus Yunzhi polysaccharide and the flavonoids from the natural medicinal plant Ginkgo biloba were extracted separately. When the polysaccharides from Yunzhi polysaccharides and ginkgo flavonoids were used together, they could significantly shorten the escape latency of dementia mice, improve spatial memory, and increase correct responses. The number of times, prolonging the latency period of the first mistake, reducing the number of mistakes and reducing the abnormal state of brain tissue cells, and significantly reducing the expression of collagen fibrillary acidic protein GFAP, has a certain effect on improving the memory of dementia model mice.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and food health care, and in particular relates to a memory-enhancing composition and its application. Background technique [0002] Alzheimer's disease, mainly manifested as Alzheimer's disease (AD), or dementia, is a persistent neurological dysfunction. AD is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. The main pathological features are brain atrophy, senile plaques in brain tissue, cerebral vascular deposits and neurofibrillary tangles. In the later stage, the cholinergic function in some parts of the central nervous system is mainly insufficient, so cholinergic enhancing drugs are currently the main therapeutic drugs, such as cholinesterase inhibitors donepezil, huperzine A, galantamine, rivastigmine, etc. However, cholinesterase (AChE) inhibitors are only a palliative treatment strategy that can tem...

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