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Composition for enhancing memory and its application

A technology for enhancing memory and composition, applied in the fields of biomedicine and food health care, can solve problems such as failure to improve memory, and achieve the effects of improving spatial memory ability, shortening escape latency, and prolonging error latency.

Active Publication Date: 2016-10-05
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The compounding of multiple biologically active substances can often further improve its effect, but so far, no studies have been reported on the use of compound polysaccharides of versicolor polysaccharides and ginkgo biloba flavonoids to improve memory

Method used

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  • Composition for enhancing memory and its application
  • Composition for enhancing memory and its application
  • Composition for enhancing memory and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The application principle of the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0027] 1. Purpose of the experiment

[0028] To observe the combined oral administration of Yunzhi polysaccharide and ginkgo flavonoids on the improvement of memory in dementia model mice.

[0029] 2. Experimental materials

[0030] 1. Test drug

[0031] Yunzhi polysaccharide: polysaccharide content: 30wt.%

[0032] Ginkgo flavonoids: flavonoid content: 25wt.%

[0033] Positive control drug: galantamine hydrobromide (Xi'an Janssen Pharmaceutical Co., Ltd., specifications: 28 tablets / box, 8mg / tablet, batch number: 111012730, indications: for the treatment of mild to moderate Alzheimer's dementia symptom.)

[0034] 2. Experimental animals

[0035] 2.1 Source, species, strain, certificate: Yangzhou University Comparative Medicine Center, 96 clean-grade ICR mice, animal certificate number: SCXK (Su) 2012-0004.

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Abstract

The memory-enhancing composition and its application, the active ingredients of the composition are versicolor polysaccharide and ginkgo flavonoids. The polysaccharides from the medicinal fungus Yunzhi polysaccharide and the flavonoids from the natural medicinal plant Ginkgo biloba were extracted separately. When the polysaccharides from Yunzhi polysaccharides and ginkgo flavonoids were used together, they could significantly shorten the escape latency of dementia mice, improve spatial memory, and increase correct responses. The number of times, prolonging the latency period of the first mistake, reducing the number of mistakes and reducing the abnormal state of brain tissue cells, and significantly reducing the expression of collagen fibrillary acidic protein GFAP, has a certain effect on improving the memory of dementia model mice.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and food health care, and in particular relates to a memory-enhancing composition and its application. Background technique [0002] Alzheimer's disease, mainly manifested as Alzheimer's disease (AD), or dementia, is a persistent neurological dysfunction. AD is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. The main pathological features are brain atrophy, senile plaques in brain tissue, cerebral vascular deposits and neurofibrillary tangles. In the later stage, the cholinergic function in some parts of the central nervous system is mainly insufficient, so cholinergic enhancing drugs are currently the main therapeutic drugs, such as cholinesterase inhibitors donepezil, huperzine A, galantamine, rivastigmine, etc. However, cholinesterase (AChE) inhibitors are only a palliative treatment strategy that can tem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L29/30A23L31/00A61K36/16A61P25/28A61K31/715
CPCA23L29/30A23L33/00A23V2002/00A61K31/715A61K36/16A23V2200/30A61K2300/00
Inventor 赵林果房仙颖姜艳曹福亮裴建军吴彩娥王佳宏张旭晖
Owner NANJING FORESTRY UNIV
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