13 results about "Memory Losses" patented technology

The invention provides a system and method for enhancing long-term memory of a large language model, and relates to the technical field of artificial intelligence. The system solves the problems of memory loss, information confusion and the like in multiple rounds of dialogues through hierarchical memory storage, time-aware retrieval and an automatic reflection compression mechanism, improves response consistency and credibility, and supports personalized services and complex task scenes.

The application discloses a kind of multi-step flow prediction methods based on space-time dual attention long short-term memory network, belong to deep learning and water conservancy informatization technical field.The method includes: feature perception and data preprocessing, variable attention feature screening, LSTM time series dynamics coding, extract time series deep dependence and construct full-time domain dynamics memory bank;Dynamic retrieval and multi-dimensional feature fusion, introduce step condition embedding and time decay driven cross attention mechanism to realize on-demand retrieval of historical features, and fuse near-time physical evolution inertia to ensure trajectory continuity;Result mapping and trajectory output, generate multi-step flow prediction value in parallel.The application solves the problems of spatial driving weight static, phase lag, memory loss and trajectory discontinuity in tidal river network multi-step flow prediction, and improves the prediction accuracy and stability.

Smell loss (hyposmia) is a common cognitive deficit perceived clinically as a nasal abnormality but, in reality, it is a deficit of complex biochemical detection and processing of externally generated chemical events. A major mechanism initiating hyposmia involves abnormalities of growth of human olfactory cells through altered growth factor stimulation of stem cell activity. While several growth factors are involved well known signaling substances generate and perpetuate this process; among these substances are cAMP and cGMP. We have hypothesized a role for cAMP in taste and olfaction as a growth factor necessary for stem cell maturation. We have thus measured cAMP and cGMP in parotid saliva of 19 normal subjects and 144 patients with hyposmia to evaluate roles for these signals in cognition. Results indicate that patients secrete significantly less cAMP (0.40+ / −0.03 pmol / mg protein (Mean+ / −SEM); patients; 0.67+ / −0.09, normals, p<0.005) and significantly less cGMP (0.072+ / −0.003, patients; 0.100+ / −0.007, normals, p<0.005) than do normals. While parotid gland secretions relate directly to taste bud growth factors many substances secreted in saliva are similar to those secreted in nasal mucus. The present results indicate aberrant signaling in saliva may serve both as a marker for hyposmia and as an indicator of a mechanism which interferes with olfactory system function.

The invention discloses a brain-computer interface method and device for enhancing brain memory and function. The brain-computer interface device comprises a signal generating and sending device which comprises a micro sensor array chip capable of collecting signals of multiple frequencies. The signal generator of the device can send out trigger signals with different frequencies, including electrical signals, and the signal receiver can collect multi-frequency feedback signals of the brain for the trigger signals. The device may also assist the brain in holding information, optimizing writing and storage and reading of information, and optimizing addresses and distribution of information storage, including refreshing information and reformatting physical distribution of information storage, to improve efficiency and accuracy of writing, holding and reading of information. When the brain refreshes the memory, the device records and downloads the content of the information so as to backup the memory and prevent the memory loss problem. According to the invention, the information stored in the brain can be transferred to another region of the brain or the in-vitro information memory, and the brain information can be edited.

The present disclosure provides, among other things, human codon-optimized sequences encoding presenilin 1, and methods for using the sequences in gene therapy to treat neurodegenerative diseases including, but not limited to Alzheimer's disease, frontotemporal dementia, frontotemporal lobar degeneration, Pick's disease, Lewy body dementia, memory loss, and cognitive impairment including mild cognitive impairment (MCI).

The invention provides a composition containing melatonin and probiotics and application of the composition in the aspect of improving sleep. The composition can effectively improve sleep, reduce sleep latency, increase non-rapid eye movement sleep (NREM) time, improve immunity, protect gastrointestinal functions, improve intestinal health, relieve pressure and improve mood problems, inattention, cognitive dysfunction, memory deterioration and the like caused by sleep disorders.

The present disclosure provides, among other things, methods for using presenilin based gene therapy to treat neurodegenerative dementia including, but not limited to Alzheimers disease, frontotemporal dementia, frontotemporal lobar degeneration, Picks disease, Lewy body dementia, memory loss, and cognitive impairment including mild cognitive impairment (MCI).

The application discloses a kind of composition and its application, the composition is suitable for such as student group etc. The crowd engaged in high-intensity brain work, can improve the cognitive function decline and nerve injury caused by "chronic sleep deprivation (CSD)". It contains traditional Chinese medicine decoction pieces (according to daily amount) are: prepared 4.5~13.5g rhizoma polygonati, mulberry 4.5~13.5g, medlar seed 4.5~13.5g, longan meat 3~9g, chrysanthemum 3~9g, dried tangerine or orange peel 1.5~4.5g. Its preparation method is: the above-mentioned natural medicine is extracted by water extraction method after being separated or mixed, and the extract is spray dried to prepare powder. The powder is mixed uniformly to prepare the concentrated product. The water extract components have synergistic effect, can significantly alleviate the insufficient sleep caused by long-term passive overtime, and then the cognitive function decline, memory loss and emotional regulation imbalance caused by neuron damage.

We provide a drug that uses herbal ingredients to help prevent and treat memory loss. [Solution] The formula contains at least red ginseng and Polygala tenuifolia, and in addition, Angelica sinensis, Ligusticum chuanxiong, Peony root, Rehmannia glutinosa, Glycyrrhiza uralensis, Poria cocos, Atractylodes macrocephala, Viper rhizome, Dioscorea japonica, Schisandra chinensis, and ox bile as active ingredients.

The present disclosure relates to the use of inositol-stabilized arginine (“ASI”) for improving cognition. For example, in some implementations, methods include administering an amount of ASI effective to improve cognition in humans. Some embodiments include the use of ASI for improving mental focus and / or attention span. For example, in some implementations, methods include administering an amount of ASI effective to improve mental focus and / or attention span in humans. Some embodiments include the use of ASI for treating and / or preventing cognitive disorders. Cognitive disorders may include stroke, anoxic brain injury, traumatic brain injury, dementia, Alzheimer's disease, Parkinson's disease, MCI, and age-related memory loss, attention deficit hyperactivity disorder (“ADHD”), and other learning disabilities.

The system according to the embodiment aims to enable patients with memory loss or dementia to search for information based on fragmented memories and analyze their responses. [Solution] A system according to an embodiment includes an input unit, a search unit, a display unit, a recording unit, and an analysis unit. The input unit inputs keywords. The search unit searches for information based on the keywords input by the input unit. The display unit displays the information searched for by the search unit. The recording unit records the user's reaction to the information displayed by the display unit. The analysis unit analyzes the reaction recorded by the recording unit.

The disclosure relates to nucleic acid expression cassettes for the treatment of neurodegenerative disorders. Methods of treating neurodegenerative disorders such as Alzheimer's disease, frontotemporal dementia, frontotemporal lobar degeneration, Pick's disease, Lewy body dementia, memory loss, cognitive impairment, and mild cognitive impairment are also provided.

The present invention relates to a composition for alleviating, preventing, or treating Alzheimer's disease, the composition comprising apigenin and oxyresveratrol. A composition according to the present invention is highly effective in reducing Alzheimer's disease pathology caused by β-amyloid, which is increased by aging and oxidative stress, and improving β-amyloid-induced memory loss and cognitive function.