51 results about "Memory Losses" patented technology

The invention discloses a method for extracting and optimizing large model memory based on historical dialogue entities. S1, acquiring a historical dialogue record; s2, performing information extraction on the historical dialogue records; s3, storing the vector set; s4, acquiring user input; s5, judging the consistency of the information; s6, inputting a data information combination; s7, obtaining an output result of the large language model; s8, continuously answering questions and answers; according to the method, the historical session records are extracted in a machine learning model entity extraction mode, the degree of dependence of a machine learning model on hardware is low, the use cost can be effectively reduced, and due to the fact that the context of questions and answers can be always contacted with each dialogue and memory information, the user experience is improved. And the problem of memory loss caused by too long rounds is not caused.

The invention discloses a pre-inquiry method based on a long and short term memory management large model. The pre-inquiry method comprises the following steps: S100, acquiring identity information and complaint symptom information of a patient; s200, establishing long-term memory and short-term memory corresponding to the patient; all information generated in the pre-inquiry dialogue process is stored in the short-term memory; the long-term memory and the short-term memory are updated and maintained based on a memory storage mechanism; s300, based on the long-term memory and the short-term memory, using a large model to construct multiple rounds of pre-inquiry dialogues, and obtaining patient condition information; and S400, summarizing the patient identity information, the complaint symptom information, the long-term memory and the short-term memory to generate a pre-inquiry report. According to the pre-inquiry method based on the long-short-term memory management large model, the long-short-term memory management is separated from the large model to carry out multiple rounds of pre-inquiry dialogues, the method does not need to depend on the memory ability of the large model, and the memory loss phenomenon in multiple rounds of dialogues commonly seen in an existing large model can be effectively avoided.

The invention provides a system and method for enhancing long-term memory of a large language model, and relates to the technical field of artificial intelligence. The system solves the problems of memory loss, information confusion and the like in multiple rounds of dialogues through hierarchical memory storage, time-aware retrieval and an automatic reflection compression mechanism, improves response consistency and credibility, and supports personalized services and complex task scenes.

The embodiment of the invention relates to generative language model forgetting learning. A computing system includes one or more processing devices configured to receive a forgotten data set including a forgotten target prompt-output pair. Each forgetting target cue-output pair includes a forgetting target cue that has been input to the generative language model and a forgetting target output that is generated in the generative language model. The processing device is further configured to receive a memory data set comprising memory target cue-output pairs, each memory target cue-output pair comprising a memory target cue that has been input to the generative language model and a memory target output that is generated in the generative language model. The processing device is further configured to calculate a forgotten learning loss item and a memory loss item based at least in part on the forgotten data set and the memory data set, respectively. The processing device is further configured to perform a forgetting learning update in the generative language model by performing a gradient descent for the loss including the loss item.

The invention belongs to the technical field of biomedicine, discloses a method for screening markers based on a data model constructed by a GWAWS data set and application of the method in diagnosis of diabetic hypomnesia type mild cognitive impairment, and discloses a serum exosome miR-125a-5p molecular marker for the first time. Experiments find that the expression change in diabetic patients with hypomnetic mild cognitive impairment is significant, and the expression change is significantly related to occurrence of hypomnetic mild cognitive impairment and poor scene memory performance; the invention further discloses a kit containing the molecular marker, the sensitivity of the kit in diagnosis of hypomnesia type mild cognitive impairment of diabetic patients reaches 0.63, and the specificity reaches 0.67; therefore, the serum exosome miR-125a-5p molecular marker provided by the invention can be used as a marker for risk estimation and detection of hypomemory mild cognitive impairment of diabetic patients, and is beneficial to screening, prevention and treatment of cognitive impairment of diabetic patients.

A Maclura pubescens extract or fraction or a Prunus cerasoides extract or fraction having neuroglobin (Ngb) activation and neuroprotective effects and, on the basis thereof, a neuroprotective composition containing, as an active ingredient, a Maclura pubescens extract or fraction or a Prunus cerasoides extract or fraction. The neuroprotective composition can be used, through the activation of neuroglobin (Ngb), as a pharmaceutical composition or a food composition for treatment, alleviation and prevention of a stroke, a cerebral infarction, thrombosis, cerebral degenerative disease, vascular dementia, memory loss, short-term memory impairment, a concentration disorder, anxiety, nervousness and the like, and for brain damage protection, brain function improvement and cranial nerve cell protection.

The application discloses a kind of multi-step flow prediction methods based on space-time dual attention long short-term memory network, belong to deep learning and water conservancy informatization technical field.The method includes: feature perception and data preprocessing, variable attention feature screening, LSTM time series dynamics coding, extract time series deep dependence and construct full-time domain dynamics memory bank;Dynamic retrieval and multi-dimensional feature fusion, introduce step condition embedding and time decay driven cross attention mechanism to realize on-demand retrieval of historical features, and fuse near-time physical evolution inertia to ensure trajectory continuity;Result mapping and trajectory output, generate multi-step flow prediction value in parallel.The application solves the problems of spatial driving weight static, phase lag, memory loss and trajectory discontinuity in tidal river network multi-step flow prediction, and improves the prediction accuracy and stability.

The present invention relates to nitrogen-containing heterocyclic compound derivatives and uses thereof. The compounds according to the present invention can exert therapeutic effects on various neurological disorders, such as neurodegenerative diseases, neurodegenerative pathologies, neuropsychiatric disorders, memory loss, cognitive dysfunction / impairment, and impairment of extinction learning, by effectively enhancing synaptic plasticity without side effects.

The invention provides a large model memorizing method and device and a computer readable storage medium. The method comprises the steps of obtaining a current theme and corresponding theme content according to a current answer process of a user; storing the current theme and the corresponding theme content into a first layer of memory cache; storing the historical theme and the corresponding theme content into a second layer of memory cache; receiving a latest questioning question input by a user, and filling the latest questioning question, the current theme in the first-layer memory cache and the corresponding theme content, and at least one historical theme in the second-layer memory cache and the corresponding theme content into a preset large-model questioning template; and inputting the filled large model question template into the large model to obtain the content returned by the large model based on the large model question template. According to the method, the device and the computer readable storage medium, the problem of large model memory loss or confusion in multiple rounds of sessions in the prior art can be solved.

Smell loss (hyposmia) is a common cognitive deficit perceived clinically as a nasal abnormality but, in reality, it is a deficit of complex biochemical detection and processing of externally generated chemical events. A major mechanism initiating hyposmia involves abnormalities of growth of human olfactory cells through altered growth factor stimulation of stem cell activity. While several growth factors are involved well known signaling substances generate and perpetuate this process; among these substances are cAMP and cGMP. We have hypothesized a role for cAMP in taste and olfaction as a growth factor necessary for stem cell maturation. We have thus measured cAMP and cGMP in parotid saliva of 19 normal subjects and 144 patients with hyposmia to evaluate roles for these signals in cognition. Results indicate that patients secrete significantly less cAMP (0.40+ / −0.03 pmol / mg protein (Mean+ / −SEM); patients; 0.67+ / −0.09, normals, p<0.005) and significantly less cGMP (0.072+ / −0.003, patients; 0.100+ / −0.007, normals, p<0.005) than do normals. While parotid gland secretions relate directly to taste bud growth factors many substances secreted in saliva are similar to those secreted in nasal mucus. The present results indicate aberrant signaling in saliva may serve both as a marker for hyposmia and as an indicator of a mechanism which interferes with olfactory system function.

The present invention relates to a nitrogen-containing heterocyclic compound derivative and its use. The compound according to the present invention can effectively improve synaptic plasticity without side effects, thereby exerting therapeutic effects on various neurological disorders such as neurodegenerative diseases, neurodegenerative pathologies, neuropsychiatric disorders, memory loss, cognitive dysfunction / injury, and extinction learning disorders.

The invention discloses a brain-computer interface method and device for enhancing brain memory and function. The brain-computer interface device comprises a signal generating and sending device which comprises a micro sensor array chip capable of collecting signals of multiple frequencies. The signal generator of the device can send out trigger signals with different frequencies, including electrical signals, and the signal receiver can collect multi-frequency feedback signals of the brain for the trigger signals. The device may also assist the brain in holding information, optimizing writing and storage and reading of information, and optimizing addresses and distribution of information storage, including refreshing information and reformatting physical distribution of information storage, to improve efficiency and accuracy of writing, holding and reading of information. When the brain refreshes the memory, the device records and downloads the content of the information so as to backup the memory and prevent the memory loss problem. According to the invention, the information stored in the brain can be transferred to another region of the brain or the in-vitro information memory, and the brain information can be edited.

1. The name of the product of this design: Graphical user interface for thinking training for electronic devices (filled building blocks). 2. Purpose of this design product: This design product is used for an electronic device. 3. The design highlights of this appearance design product are the graphical user interface content on the screen. 4. The picture or photo that best illustrates the key points of the design: main view. 5. There are no design points, and the rear view, left view, right view, top view and bottom view are omitted. 6. Purpose of graphical user interface: Graphical user interface used to train the thinking ability of patients with cognitive impairment, memory loss, and mental illness. In the interface shown in the main view, when the user clicks the start training button, the interface change state diagram 1 will be displayed. In the interface shown in Figure 1, the user performs specified operations by dragging the building blocks in the middle of the interface. In the interface shown in the interface change state diagram 1, when the user operation time reaches the specified time, the interface change state diagram 2 will be displayed. In the interface shown in the interface change state diagram 2, the interface change state diagram 3 will be displayed after the interface is displayed for a specified time.

The present invention relates to nitrogen-containing heterocyclic compound derivatives and uses thereof. The compounds according to the present invention can exert therapeutic effects on various neurological disorders, such as neurodegenerative diseases, neurodegenerative pathologies, neuropsychiatric disorders, memory loss, cognitive dysfunction / impairment, and impairment of extinction learning, by effectively enhancing synaptic plasticity without side effects.

1. The name of this design product: Cartoon image dynamic graphical user interface for thinking training for electronic equipment (focus on the kitchen). 2. Purpose of this design product: This design product is used for an electronic device. 3. The design highlights of this appearance design product are the graphical user interface content on the screen. 4. The picture or photo that best illustrates the key points of the design: main view. 5. There are no design points, and the rear view, left view, right view, top view and bottom view are omitted. 6. Purpose of graphical user interface: Graphical user interface used to train the thinking ability of patients with cognitive impairment, memory loss, and mental illness. In the interface shown in the main view, when the user clicks the cage image in the middle of the interface, the animation effects shown in interface change state diagram 1 to interface change state diagram 7 will be displayed in sequence. Interface change state diagram 1 to interface change state diagram 7 are animation effect key frames.

1. The name of the product of this design: Graphical user interface for thinking training help prompts for electronic devices (digital coloring help prompts). 2. Purpose of this design product: This design product is used for an electronic device. 3. The design highlights of this appearance design product are the graphical user interface content on the screen. 4. The picture or photo that best illustrates the key points of the design: main view. 5. There are no design points, and the rear view, left view, right view, top view and bottom view are omitted. 6. Purpose of the graphical user interface: A help prompt graphical user interface for a thinking ability training system for patients with cognitive impairment, memory loss, and mental illness. In the interface shown in the main view, when the user clicks the Pause / Help button, the interface change state diagram 1 will be displayed. In the interface shown in the interface change state diagram 1, when the user clicks the Next button, the interface change state diagram 2 will be displayed. In the interface shown in the interface change state diagram 2, when the user clicks the Next button, the interface change state diagram 3 will be displayed. In the interface shown in the interface change state diagram 3, when the user clicks the next button, the interface change state diagram 4 will be displayed.

1. The name of the product of this design: Graphical user interface for thinking training for electronic devices (overlapping smiley faces). 2. Purpose of this design product: This design product is used for an electronic device. 3. The design highlights of this appearance design product are the graphical user interface content on the screen. 4. The picture or photo that best illustrates the key points of the design: main view. 5. There are no design points, and the rear view, left view, right view, top view and bottom view are omitted. 6. Purpose of graphical user interface: Graphical user interface used to train the thinking ability of patients with cognitive impairment, memory loss, and mental illness. In the interface shown in the main view, when the user clicks the start training button, the interface change state diagram 1 will be displayed. In the interface shown in Figure 1, the user drags the expression control in the middle of the interface to perform a specified operation. In the interface shown in the interface change state diagram 1, when the user operation time reaches the specified time, the interface change state diagram 2 will be displayed. In the interface shown in the interface change state diagram 2, the interface change state diagram 3 will be displayed after the interface is displayed for a specified time.

1. The name of the product of this design: Graphical user interface for thinking training for electronic devices (two-color chess). 2. Purpose of this design product: This design product is used for an electronic device. 3. The design highlights of this appearance design product are the graphical user interface content on the screen. 4. The picture or photo that best illustrates the key points of the design: main view. 5. There are no design points, and the rear view, left view, right view, top view and bottom view are omitted. 6. Purpose of graphical user interface: Graphical user interface used to train the thinking ability of patients with cognitive impairment, memory loss, and mental illness. In the interface shown in the main view, when the user clicks the start training button, the interface change state diagram 1 will be displayed. In the interface shown in Figure 1, the user performs the specified operation by sliding the two-color chess piece in the middle of the interface. In the interface shown in the interface change state diagram 1, when the user operation time reaches the specified time, the interface change state diagram 2 will be displayed. In the interface shown in the interface change state diagram 2, the interface change state diagram 3 will be displayed after the interface is displayed for a specified time.

Here, the Inventors show that chronic IL- 1 -induced H2A.X signaling, which mediated DNA DSB response, in hippocampal neurons is a critical driver of cognitive deficits in chronic low grade neuroinflammation. They show that mice chronically infected with the brain- persisting T. gondii parasite display deficits in spatial memory consolidation without general memory loss. Extensive mapping of the neuroinflammatory landscape, beyond a latent T. gondii infection elicited type 1-like neuroinflammation, display elevated production of IL-1α and IL-1β in the hippocampus. Using a mouse model to specifically delete the IL-1 receptor from excitatory neurons, they uncovered that neuronal IL-1 signaling is required for the spatial memory deficits caused by latent T. gondii infection. By singling out a chronic exposure to IL- ip they found that IL-1β signaling in neurons indeed impairs spatial memory. Moreover, they showed that chronic exposure to IL-1β increases DNA DSB levels in neurons, and that neuronal H2A.X-dependent DSB response mediates the IL-1β-induced memory deficits. Importantly, neuronal DSBs were also increased upon T. gondii infection and the deficit in hippocampus- dependent spatial memory caused by T. gondii infection was prevented by the abrogation of neuronal H2A.Xdependent signaling. These results highlight the instrumental role of cytokine- induced DSB-dependent signaling in spatial memory defects elicited by a chronic infectious neuroinflammatory process. Accordingly, the present invention relates to a method of treating a subject suffering from cognitive deficit comprising administering to said subject a therapeutically effective amount of an inhibitor of IL- 1 -induced H2A.X signaling.

The present disclosure provides, among other things, human codon-optimized sequences encoding presenilin 1, and methods for using the sequences in gene therapy to treat neurodegenerative diseases including, but not limited to Alzheimer's disease, frontotemporal dementia, frontotemporal lobar degeneration, Pick's disease, Lewy body dementia, memory loss, and cognitive impairment including mild cognitive impairment (MCI).

The invention provides a composition containing melatonin and probiotics and application of the composition in the aspect of improving sleep. The composition can effectively improve sleep, reduce sleep latency, increase non-rapid eye movement sleep (NREM) time, improve immunity, protect gastrointestinal functions, improve intestinal health, relieve pressure and improve mood problems, inattention, cognitive dysfunction, memory deterioration and the like caused by sleep disorders.

The present disclosure provides, among other things, methods for using presenilin based gene therapy to treat neurodegenerative dementia including, but not limited to Alzheimers disease, frontotemporal dementia, frontotemporal lobar degeneration, Picks disease, Lewy body dementia, memory loss, and cognitive impairment including mild cognitive impairment (MCI).

1. The name of the product of this design: Graphical user interface for thinking training (number chain) for electronic devices. 2. Purpose of this design product: This design product is used for an electronic device. 3. The design highlights of this appearance design product are the graphical user interface content on the screen. 4. The picture or photo that best illustrates the key points of the design: main view. 5. There are no design points, and the rear view, left view, right view, top view and bottom view are omitted. 6. Purpose of graphical user interface: Graphical user interface used to train the thinking ability of patients with cognitive impairment, memory loss, and mental illness. In the interface shown in the main view, when the user clicks the start training button, the interface change state diagram 1 will be displayed. In the interface shown in Figure 1, the user drags the digital control in the middle of the interface to perform the specified operation. In the interface shown in the interface change state diagram 1, when the user operation time reaches the specified time, the interface change state diagram 2 will be displayed. In the interface shown in the interface change state diagram 2, the interface change state diagram 3 will be displayed after the interface is displayed for a specified time.

The present invention discloses a subjective risk assessment system for memory loss, comprising: a first information setting module for setting the identity information of a patient; a second information setting module for setting the identity of an assessor; an assessment module for receiving assessment information of a patient input by an assessor; a calculation module for analyzing and calculating the assessment information input by the assessor to obtain an assessment score; and a risk module for assessing the risk level of the patient according to the assessment score calculated by the calculation module. The subjective risk assessment system for memory loss of the present invention can discover risk indicators for predicting early symptoms of dementia from the subjective complaints of memory loss, and can be suitable for non-professionals, especially family self-assessment, thereby pushing the risk assessment work of dementia-related memory loss to the pre-hospital stage, reducing the time and manpower cost pressure of in-hospital examinations.

The present invention discloses a structure for magnetic coils that integrate a magnetic stimulation device, wherein the arrangement of a plurality of magnetic coils generates a vortex magnetic field to stimulate areas of interest, for example, towards the hippocampus in the brain of a subject in order to reduce Tau protein phosphorylation, which is an indicator of cognitive process pathologies such as memory loss, learning difficulties or diseases such as Alzheimer's disease. The present invention integrates a magnetic emitter based on modular magnetic coils to generate a vortex magnetic field, either around a body part of a subject or on their head, chest or abdomen. Alternatively, the magnetic stimulation device has cooling means that reduce the temperature of the magnetic coils during their operation, in a slim, portable structural configuration. Control means are used to adjust the characteristics of the desired magnetic field and the area where it is applied by controlling the power and frequency provided to each of them.

The invention relates to a nitrogen-containing heterocyclic compound derivative and application thereof. The compound of the present invention can exert a therapeutic effect on various neurological disorders such as neurodegenerative diseases, neurodegenerative diseases, neuropsychiatric disorders, memory loss, cognitive dysfunction / impairment, and learning regression disorders by effectively enhancing synaptic plasticity without side effects.

Provided are oligomeric agents, pharmaceutical compositions, and methods for reducing the amount or activity of APOE RNA in a cell or subject, and in certain instances reducing the amount of ApoE protein in a cell or subject. Such oligomeric agents, pharmaceutical compositions, and methods are useful to ameliorate at least one symptom of a neurodegenerative disease. Such symptoms include cognitive impairment, progressive memory loss, a decline in language skills, behavioral abnormality, dementia, difficulty performing daily activities, aphasia, agnosia, apraxia, loss of motor function, amyloid plaque, neurofibrillary tangle, and / or neuroinflammation.

The present disclosure relates to double-stranded ribonucleic acid (dsRNAi) agents and compositions that target the actin-binding LIM protein 3 (ABLIM3) gene, methods of inhibiting the expression of the ABLIM3 gene, and methods of treating a subject having an ABLIM3-related disease or disorder, such as PTSD or age-related memory loss, using such dsRNAi agents and compositions.

The application discloses a kind of composition and its application, the composition is suitable for such as student group etc. The crowd engaged in high-intensity brain work, can improve the cognitive function decline and nerve injury caused by "chronic sleep deprivation (CSD)". It contains traditional Chinese medicine decoction pieces (according to daily amount) are: prepared 4.5~13.5g rhizoma polygonati, mulberry 4.5~13.5g, medlar seed 4.5~13.5g, longan meat 3~9g, chrysanthemum 3~9g, dried tangerine or orange peel 1.5~4.5g. Its preparation method is: the above-mentioned natural medicine is extracted by water extraction method after being separated or mixed, and the extract is spray dried to prepare powder. The powder is mixed uniformly to prepare the concentrated product. The water extract components have synergistic effect, can significantly alleviate the insufficient sleep caused by long-term passive overtime, and then the cognitive function decline, memory loss and emotional regulation imbalance caused by neuron damage.

The present invention relates to a memory optimization method. The method matches the similarity between a page and other pages according to JS files and CSS files loaded by the pages. When similar pages are matched, a memory sharing layer 1 is established. A memory creation method is used to count the memory byte blocks 1 created, and a threshold for creating the memory byte 1 is set. The created memory byte blocks 1 are stored in the sharing layer 1. An address mapping relationship between the shared memory and the virtual memory address 1 of the browser page is established. Then, a memory reading method is used to read the memory sharing layer 1 memory when a mapping exists, otherwise the data is directly read. A memory modification method is used to modify unmapped memory and enter the memory sharing layer 1. If a mapping exists, the incremental modification content is recorded. The present invention can improve the memory usage of similar web pages, allow similar memory blocks to reuse the same memory, thereby reducing memory occupation and solving memory loss.