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Gelatin particle and use thereof, and device for administration of physiologically active substance

A technology of physiologically active substances and gelatin particles, which is applied in the field of gelatin particles, can solve problems such as difficult porosity control, stability occurrence problems, difficult impregnation volume homogenization, etc., and achieve excellent stress deformation recovery ability, excellent stability, and excellent ability Effect

Inactive Publication Date: 2014-03-26
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since it is difficult to control the porosity, there is a problem that it is difficult to homogenize the amount of impregnation per particle unit
In the case of particles swollen to such a large extent, the mechanical strength of the swollen particles decreases excessively and there is a possibility that a problem occurs in terms of firmness (mechanical strength and shape retaining ability)
In addition, when gelatin particles cross-linked with a cross-linking agent are administered to a living body, it is necessary to consider the toxicity of the cross-linking agent remaining in the gelatin particles, which limits the use of cross-linking agents.

Method used

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  • Gelatin particle and use thereof, and device for administration of physiologically active substance
  • Gelatin particle and use thereof, and device for administration of physiologically active substance
  • Gelatin particle and use thereof, and device for administration of physiologically active substance

Examples

Experimental program
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Effect test

Embodiment 1～16

[0071] A medium-chain fatty acid glyceride was used as an oil for dispersing gelatin, and an aqueous gelatin solution (derived from white pigskin, concentration: 5% by weight) was dropped and dispersed therein at 10° C. or less to prepare gelatin particles. Subsequently, the gelatin particles were cooled (0° C.) under stirring to achieve thorough gelation, and then acetone was added as a solvent to replace the water in the gelatin particles.

[0072] Then, after washing the gelatin particles with acetone as a washing solvent, the particles were dried to obtain nonporous spherical dried gelatin particles. The obtained gelatin particles were classified and recovered into four kinds of gelatin particles having particle diameters of 425-600 μm, 212-300 μm, 75-150 μm, and 25-63 μm. The four kinds of classified and recovered gelatin particles were heat-treated at a predetermined temperature for 4 to 5 hours in a static state under vacuum conditions (5 kPa) to obtain gelatin particle...

Embodiment 1

[0074] Embodiment 1: particle size is 425~600 μm, heating temperature: 150 ℃ (± 5 ℃)

Embodiment 2

[0075] Embodiment 2: particle size is 212~300 μ m, heating temperature: 150 ℃ (± 5 ℃)

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Abstract

The present invention relates to a gelatin particle and a device for administration of a physiologically active substance. The gelatin particle is a thermally crosslinked non-porous spherical gelatin particle having a circularity of 0.8 or more and a dry particle diameter of 20 to 1,600 [mu]m. The average volume swelling ratio of the gelatin particle in a case where the gelatin particle is immersed in physiological saline at 23 DEG C is from 200 to 2,000% relative to an average volume of the gelatin particle in a dried state. As for a swollen gelatin particle, it is preferable that the gelatin used has a jelly strength of 80 to 120 g and the swollen gelatin particle has a particle diameter of 50 to 2,000 [mu]m. The gelatin particle can be used for blood vessel embolization and also for controlled release of physiologically active substance.

Description

technical field [0001] The present invention relates to gelatin particles and gelatin particles for controlled release of physiologically active substances, and devices for administering physiologically active substances. Specifically, the present invention relates to nonporous spherical gelatin particles having a specific volume swelling ratio, and gelatin particles in which physiologically active substances are dissolved and held in such gelatin particles, and in which physiologically active substances are dissolved, impregnated, and held therein. A device in which gelatin particles of the active substance are dispersed in a syringe together with saline. Background technique [0002] Gelatin is a protein obtained by heat-treating collagen followed by extraction and is a commonly used material in various fields, for example, it is used as a gelling agent in food jelly and medicine and for industrial purposes such as adhesives and film. Among these various uses, gelatin an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K47/42A61P35/00
CPCA61K47/46A61K9/16C08H1/06C08J3/247A61K47/42A61K9/1658C08J2389/00Y10T428/2982A61P35/00
Inventor 三浦智惠子真壁美纪阿部绘梨子菅原晋二吉川利之
Owner NITTO DENKO CORP
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